- Palladium-Catalyzed ortho-Benzoylation of Sulfonamides through C?H Activation: Expedient Synthesis of Cyclic N-Sulfonyl Ketimines
-
The ortho-carbonylation of sulfonylarenes by non-hazardous aryl aldehydes as a carbonyl precursor was reported. In this method, the sulfonamide group serves as a directing group for C?H activation in the presence of a Pd catalyst under ligand-free conditions. The scope of this strategy has been extended to the one-pot two-step synthesis of cyclic N-sulfonyl ketimines under mild reaction conditions. Our approach could be considered as an alternative by circumventing the use of highly reactive organolithium or Grignard reagents to access a wide range of biologically potent cyclic N-sulfonyl ketimines. (Figure presented.).
- Ojha, Subhadra,Panda, Niranjan
-
p. 561 - 571
(2019/12/24)
-
- Iridium(III)-Catalyzed Selective and Mild C-H Amidation of Cyclic N-Sulfonyl Ketimines with Organic Azides
-
A general protocol for iridium catalyzed direct C?H amidation of cyclic N-sulfonyl ketimines using sulfonyl, acyl and aryl azides as nitrogen source is reported herein. The reaction takes place at room temperature with acyl and aryl azides, while an elevated temperature needed with sulfonyl azides to furnish aminated sultams in excellent yields with complete chemo and regioselectivity, thus providing a robust and environmentally benign process to the synthesis of aminosultams. (Figure presented.).
- Maraswami, Manikantha,Chen, Gang,Loh, Teck-Peng
-
supporting information
p. 416 - 421
(2017/11/13)
-
- A Facile One-Pot Procedure for the Synthesis of 1,2-Benzisothiazole 1,1-Dioxides
-
ortho-Lithiated N,N-diphenylbenzenesulfonamides 6 react with aromatic nitriles and N,N-dimethylcarbamonitrile, respectively, to give directly the corresponding 3-substituted 1,2-benzisothiazole-1,1-dioxides 8a-f.Other cyano compounds only transfer the cyano group or its ligands to generate the o-substituted benzenesulfonamides 9a-d.
- Hellwinkel, D.,Karle, R.
-
p. 394 - 395
(2007/10/02)
-