"Structured Nuclei" of 4-(Octadecyloxy)benzoic Acid Monolayer for Induced Nucleation of 4-Hydroxybenzoic Acid Monohydrate As Determined by Grazing Incidence X-ray Diffraction on the Aqueous Solution
A monolayer of 4-(octadecyloxy)benzoic acid at the air-solution interface has been used to induce oriented nucleation of three-dimensional (3-D) crystals of 4-hydroxybenzoic acid (HBA) minohydrate.The two-dimensional (2-D) crystalline structure of this mo
Potential Antiatherosclerotic Agents. 4. benzoic Acid Analogues of Cetaben
The synthesis of a series of analogues in which the alkyl group of cetaben is substituted with various functional groups or replaced entirely by a functionalized alkanoyl moiety is described.Also reported are the syntheses of branched-chain (alkylamino)be
DeVries, Vern G.,Largis, Elwood E.,Miner, Thomas G.,Shepherd, Robert G.,Upeslacis, Janis
p. 1411 - 1421
(2007/10/02)
Potential antiatherosclerotic agents. 2. (Aralkylamino)- and (alkylamino)benzoic acid analogues of cetaben
The syntheses of a series of (aralkylamino)- and (alkylamino)benzoic acids, as well as the corresponding esters and sodium salts, are described. The compounds were evaluated in vivo in rats for serum sterol and triglyceride lowering activity and in vitro
Potential Antiatherosclerotic Agents. 3. Substituted Benzoic and Non Benzoic Acid Analogues of Cetaben
The synthesis of a series of analogues in which the carboxylic acid group of cetaben is replaced by carboxylate ester, carboxamide, or a variety of other substituent groups is described.Also reported are the syntheses of analogues in which the phenyl ring of cetaben is either modified by the presence of additional substituents or replaced entirely by another moiety.Structure-activity relationships of these compounds both as hypolipidemic agents and as inhibitors of the enzyme fatty acyl-CoA:cholesterol acyltransferase (ACAT) are discussed.Analogue syntheses designed to produce compounds that would be better absorbed orally than cetaben failed to yield any congeners of enhanced biological activity.In contrast, analogue syntheses directed toward non carboxylic acids of similar acidity to cetaben produced a very active class of sulfonamides.
Albright, J. Donald,DeVries, Vern G.,Du, Mila T.,Largis, Elwood E.,Miner, Thomas G.,et al.
p. 1393 - 1411
(2007/10/02)
Process for preparing 4-(n-hexadecylamino)-benzoic acid
Preparation of 4-(n-hexadecylamino)-benzoic acid or salt thereof employing as catalyst quaternary ammonium or phosphonium salt.
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(2008/06/13)
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