55986-43-1 Usage
Biological Activity
cetaben is an unique pparα-independent peroxisome proliferator.the fibrate class of hypolipidemic drugs, such as fenofibrate and clofibrate, elicit their effects via binding to and activating peroxisome proliferator-activated receptor α (pparα).
in vitro
previous study showed that cetaben could cause little but reversible proliferation and morphological heterogeneity with the occurrence of dumbbell- and cup-shaped peroxisomal profiles. peroxisomes in hepg2 cells showed marked variation in size and shape. cetaben treatment of hepg2 cells was able to lead to disintegration of golgi regions and augmented mitochondrial matrix [1].
in vivo
animal study found that the changes in large scale of liver non-peroxisomal parameters were compared after 10 days administration of both cetaben and clofibric acid 200 mg/kg/day to male wistar rats. no analogical changes were observed after cetaben treatment in the livers of experimental animals. it was also found that both drugs could increase the activities of alanine-glyoxylate aminotransferase-1 and acetylcarnitine transferase--enzymes with proven mitochondrial and peroxisomal location. contrary to clofibric acid, cetaben did not increase solubilization of peroxisomal enzymes [2].
references
[1] kovacs, w. ,walter, i., and stangl, h. cetaben-induced changes on the morphology and peroxisomal enzymes in mh1c1 rat hepatoma and hepg2 human hepatoblastoma cells. histochemistry and cell biology 115, 509-519 (2001).[2] chandoga, j. ,hampl, l.,turecky, l., et al. cetaben is an exceptional type of peroxisome proliferator. international journal of biochemistry 26(5), 679-696 (1994).
Check Digit Verification of cas no
The CAS Registry Mumber 55986-43-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,9,8 and 6 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 55986-43:
(7*5)+(6*5)+(5*9)+(4*8)+(3*6)+(2*4)+(1*3)=171
171 % 10 = 1
So 55986-43-1 is a valid CAS Registry Number.
InChI:InChI=1/C23H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-24-22-18-16-21(17-19-22)23(25)26/h16-19,24H,2-15,20H2,1H3,(H,25,26)
55986-43-1Relevant articles and documents
"Structured Nuclei" of 4-(Octadecyloxy)benzoic Acid Monolayer for Induced Nucleation of 4-Hydroxybenzoic Acid Monohydrate As Determined by Grazing Incidence X-ray Diffraction on the Aqueous Solution
Weissbuch, Isabelle,Berkovic, Garry,Yam, Ruth,Als-Nielsen, Jens,Kjaer, Kristian,et al.
, p. 6036 - 6045 (2007/10/02)
A monolayer of 4-(octadecyloxy)benzoic acid at the air-solution interface has been used to induce oriented nucleation of three-dimensional (3-D) crystals of 4-hydroxybenzoic acid (HBA) minohydrate.The two-dimensional (2-D) crystalline structure of this mo
Potential Antiatherosclerotic Agents. 4. benzoic Acid Analogues of Cetaben
DeVries, Vern G.,Largis, Elwood E.,Miner, Thomas G.,Shepherd, Robert G.,Upeslacis, Janis
, p. 1411 - 1421 (2007/10/02)
The synthesis of a series of analogues in which the alkyl group of cetaben is substituted with various functional groups or replaced entirely by a functionalized alkanoyl moiety is described.Also reported are the syntheses of branched-chain (alkylamino)be
Process for preparing 4-(n-hexadecylamino)-benzoic acid
-
, (2008/06/13)
Preparation of 4-(n-hexadecylamino)-benzoic acid or salt thereof employing as catalyst quaternary ammonium or phosphonium salt.
