- Nitric oxide reactivity of copper(II) complexes of bidentate amine ligands
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Two copper(II) complexes, 1 and 2 with L1 and L2 [L1 = propane-1,3-diamine; L2 = N-isopropylpropane-1,3-diamine], respectively, were synthesized and characterized structurally. In acetonitrile solution of the complexes, the Cu(II) centre was found to reduce in presence of nitric oxide gas. The formation of [CuII-NO] intermediate prior to the reduction of Cu(II) center was evidenced by UV-Vis, solution FT-IR, X-band EPR studies. This reduction led to the ligand transformation through diazotization at primary amine site in complex 1; whereas, N-nitrosation at the secondary amine site of the ligand was observed in 2. The final organic products were isolated and characterized by spectroscopic studies.
- Kalita, Aswini,Kumar, Vikash,Mondal, Biplab
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- Decomposition of amino diazeniumdiolates (NONOates): Molecular mechanisms
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Although diazeniumdiolates (X[N(O)NO]-) are extensively used in biochemical, physiological, and pharmacological studies due to their ability to release NOand/or its congeneric nitroxyl, the mechanisms of these processes remain obscure. In this
- Shaikh, Nizamuddin,Valiev, Marat,Lymar, Sergei V.
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- TRANSAMINATION OF NITROGEN-CONTAINING COMPOUNDS TO MAKE CYCLIC AND CYCLIC/ACYCLIC POLYAMINE MIXTURES
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A transamination process is described to prepare polyamine product mixtures from reactants comprising mixed nitrogen-containing compounds with binary carbon spacing between nitrogen-containing groups (a binary component). A second nitrogen-containing component with a second carbon atom spacing between nitrogen-containing groups may also be employed. The molar ratio between the binary and second components can be adjusted to customize the product composition for desired end uses.
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Page/Page column 18-21
(2012/05/31)
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- Parameters influencing the release of tertiary alcohols from the surface of "spherical" dendrimers and "linear" stylomers by neighbouring-group-assisted hydrolysis of 2-carbamoylbenzoates
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The influence of structural and physico-chemical parameters on the release of a volatile tertiary alcohol (2-methyl-l -phenyl-2-propanol) by neighbouring-group-assisted cyclisation of 2-carbamoylbenzoates at neutral pH was investigated by comparing the covalent-bond cleavage from the surface of linear, comblike poly(propylene imine) "stylomers" and their corresponding spherical, globular dendrimers. Determination of the kinetic rate constants for the stepwise intramolecular cyclisation of the 2-carbamoylben- zoate moiety by using HPLC showed that the polarity of the conjugates, and thus their solubility in the aqueous reaction medium, has a stronger influence on the rates of hydrolysis than the size (generation) or shape (linear or spherical) of the macromolecules. Furthermore, structural modifications in close proximity to the release unit, such as the presence of functionalities with catalytic activity, have a strong impact on the release efficiency of the active molecules. An understanding of the physico-chemical parameters determining the local environment of the covalent-bond cleavage site is therefore an important prerequisite to transfer the characteristics of small molecules to larger structures such as oligomers and polymers and thus to design efficient macromolecular conjugates for the controlled delivery of bioactive compounds.
- Trachsel, Alain,De Saint Laumer, Jean-Yves,Haefliger, Olivier P.,Herrmann, Andreas
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supporting information; experimental part
p. 2846 - 2860
(2009/12/04)
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- METHOD FOR PRODUCING BIS-[(3-DIMETHYLAMINO)PROPYL]AMINE (DIPROPYLENE TRIAMINE, DPTA)
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The invention relates to a method for producing bis-[(3-dimethylamino)propyl]amine (dipropylene triamine, DPTA) by continuously reacting 1,3-propylene diamine (1,3-PDA) in the presence of a heterogeneous catalyst. The inventive method is characterized by
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Page/Page column 2; 3; 9
(2008/06/13)
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- Cobalt-catalyzed amination of 1,3-propanediol: Effects of catalyst promotion and use of supercritical ammonia as solvent and reactant
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The catalytic synthesis of 1,3-diaminopropane from 1,3-propanediol and ammonia was studied in a continuous fixed-bed reactor in the pressure range 50 to 150 bar. The unsupported Co-based catalysts applied were characterized by N2 physisorption, XRD, XPS, TPR, and ammonia adsorption using pulse thermal analysis and DRIFT spectroscopy. The latter investigations revealed that the best catalyst, 95 wt% Co-5 wt% Fe, contained only very weak acidic sites, unable to chemisorb ammonia. The absence of strong acidic and basic sites was crucial to suppress the various acid/base-catalyzed side reactions (retro-aldol reaction, hydrogenolysis, alkylation, disproportionation, dimerization, oligomerization). Other important requirements for improved diaminopropane formation were the use of excess ammonia (molar ratio NH3/diol > 20) and the presence of the metastable β-Co phase. A small amount of Fe additive could efficiently hinder the transformation of this phase into the thermodynamically stable α-Co phase and thus prevent catalyst deactivation up to 10 days on stream. Application of supercritical ammonia almost doubled the selectivity to amino alcohol and diamine. The selectivity enhancement in the near-critical region is attributed to elimination of the interphase mass transport limitations and to the resulting higher surface ammonia concentration.
- Fischer,Maciejewski,Buergi,Mallat,Baiker
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p. 373 - 383
(2007/10/03)
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- A facile synthesis of the intermediates of the bicyclic organic bases: DBU and TBD
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Intermediates of DBU and TBD, N-(3-aminoproply) - ε -caprolactam and bis- (3-aminopropyl)-amine were prepared by the hydrogenolysis of N-(2-cyanoethyl) - ε - caprolactam and di- (β-cyanoethyl)-amine respectively over Raney-Ni in the presence of NaBH4 under atmospheric pressure with mild condition and good yield.
- Cheng,Liu
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p. 3191 - 3194
(2007/10/02)
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- Polyamine thiols as radioprotective agents
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The present invention relates to certain polyamine thiols which are useful as radioprotective agents.
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- KINETICS AND MECHANISM OF REACTION OF 1,3-DICHLOROPROPANE WITH AMMONIA
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The kinetics and reaction mechanism of 1,3-dichloropropane with aqueous ammonia were studied.It was shown that in the amination of 1,3-dichloropropane azetidine is hardly formed; however, intermediate reaction mixtures contain its dimer in an amount up to 10percent.A kinetic model was developed for the amination of 1,3-dichloropropane and the factors affecting the yield of reaction products were explained.
- Chernitskii, K. V.,Bobylev, V. A.
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p. 1720 - 1724
(2007/10/02)
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- KINETIC AND MECHANISM OF THE AMINATION OF AZETIDINE AND 1-(3-AMINOPROPYL)AZETIDINE
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The kinetics and mechanism of decyclization reactions of azetidine and 1-(3-aminopropyl)azetidine with ammonia and 1,3-propanediamine were investigated.It was shown that for these reactions specific acid catalysis is realized.It was also shown that substitution on the nitrogen atom does not appreciably influence the reactivity of the four-mmembered heterocycle.
- Chernitskii, K. V.,Bobylev, V. A.,Sharikov, F. Yu.
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p. 2385 - 2387
(2007/10/02)
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- Process for the dyeing of leather with anionic dyes and polyaminoamide resin as dyeing auxiliary
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To improve the affinity of anionic dyestuffs in the dyeing of leather materials, polycondensation products consisting of at least one amine of the formula STR1 in which the radicals have the meanings mentioned in the description with one dicarboxylic acid and, if desired, ω-aminocarboxylic acid or its lactam are highly suitable.
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- CYCLIC HYDROCARBONS WITH AN AMINOALKYL SIDECHAIN
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Provided are cyclic hydrocarbons of Formula I with an aminoalkyl sidechain that are useful for treating phospholipase A2 mediated conditions, diabetes, and obesity.
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- Methods and intermediates for the preparation of spermidine, homospermidine and norspermidine
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Novel azadinitriles and a method for their hydrogenation to produce spermidine, homospermidine and norspermidine.
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- CATALYTIC ALKYL GROUP EXCHANGE REACTION OF PRIMARY AND SECONDARY AMINES.
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It has been shown that primary and secondary amines undergo alkyl group exchange reactions upon treatment with palladium catalyst as depicted in an operationally simple and efficient reaction which provides a convenient method for synthesis of unsymmetrical amines. The application of the reaction for the preparation of various substituted amines and heterocyclic compounds such as hexahydropyrimidine tetrahydropyrimidine, imidazolidine, and imidazoles is described. The preparation of polyamines such as H//2N(CH//2)//mNH(CH//2)//nNH//2 (10) and H//2N(CH//2)//lNH(CH//2)//mNH(CH//2)//nNH//2 (l-n, equals 2,3; 11) is readily performed by the appadium-catalyzed reactions of azetidine (6) and aziridine (7) via azetine (9) and azirine intermediates. The mechanism the palladium-catalyzed reaction has been extensively studied on the carbonylation, racemization, and deuteurium-exchange reaction of (S)-( minus )- alpha -phenylethylamine (17).
- Murahashi,Yoshimura,Tsumiyama,Kojima
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p. 5002 - 5011
(2007/10/02)
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- Process for the preparation of 2-aryl-2H-benzotriazoles
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A process for producing benzotriazoles of the formula I STR1 wherein R1 is hydrogen or chlorine, R2 is hydrogen, chlorine, C1 -C4 alkyl, C1 -C4 alkoxy, C2 -C9 alkoxycarbonyl, carboxyl or sulfo, R3 is C1 -C12 alkyl, C1 -C4 alkoxy, phenyl, (C1 -C8 alkyl)-phenyl, C5 -C6 cycloalkyl, C2 -C9 alkoxycarbonyl, chlorine, carboxyethyl or C7 -C9 phenylalkyl, R4 is hydrogen, C1 -C4 alkyl, C1 -C4 alkoxy, chlorine or hydroxyl, and R5 is hydrogen, C1 -C12 alkyl, chlorine, C5 -C6 cycloalkyl or C7 -C9 phenylalkyl, which process comprises treating a benzotriazole-N-oxide of the formula II STR2 wherein R1, R2, R3, R4 and R5 have the above meanings, at a temperature of 20°-150° C., with an amine; or treating an o-nitroazobenzene of the formula III STR3 wherein R1, R2, R3, R4 and R5 have the above meanings, at a temperature of 20°-150° C., with an amine.
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- Bis-homophthalimides and salts thereof
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Compounds of the formula STR1 wherein A and B, which may be identical to or different from each other, are each straight alkylene of 2 to 4 carbon atoms which may have a methyl or phenyl substituent attached thereto, R1, r2, r3 and R4, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, hydroxyl, amino, nitro, acetylamino, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms or (alkyl of 1 to 3 carbon atoms)thio, R5, r6, r7 and R8, which may be identical to or different from each other, are each hydrogen, alkyl of 1 to 4 carbon atoms, phenyl-(alkyl of 1 to 4 carbon atoms) or methoxyphenyl-(alkyl of 1 to 4 carbon atoms), or R5 and R6, together with each other, are straight alkylene of 2 to 5 carbon atoms, or R7 and R8, together with each other, are straight alkylene of 2 to 5 carbon atoms, and R9 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl-(alkyl of 1 to 6 carbon atoms), And non-toxic, pharmaceutically acceptable acid addition salts thereof; the compounds as well as the salts are useful as antiarrhythmics.
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