cas 56077-78-2, (4-Chlorosulfonylphenoxy)acetic acid methyl ester

Articles about 56077-78-2Total 6 be found

Synthesis method and application of two sulfonyl pyrrolidine P-CABs
The invention discloses a synthesis method and application of two sulfonyl pyrrolidine P-CABs. The general structural formula (I) of the sulfonyl pyrrolidine is shown in the specification. The sulfonyl pyrrolidine has excellent gastric acid secretion inhibition effect. The synthesis method has the advantages of fewer process steps and easy availability of raw materials, and is suitable for industrial production.
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Paragraph 0009; 0021; 0023; 0037

(2020/09/16)

Synthesis and insecticidal activity in vitro and vivo of novel benzenesulfonyl derivatives based on potent target subunit H of V-ATPase
Two lead compounds with benzenesulfonamide were found through virtual screening based on the 3D structure of the subunit H of V-ATPase in previous study. 74 benzenesulfonyl derivatives were synthesized and their insecticidal activities were evaluated. The derivatives with propargyl substituents exhibit excellent insecticidal activities against Mythimna separata Walker. The LD50 values of compounds A5.7 (28.0 μg·g?1) and B5.7 (36.4 μg·g?1) were significantly less than that of Celangulin V (344.0 μg·g?1). Furthermore, Isothermal Titration Calorimetry (ITC) data indicate there is a strong binding affinity between A5.7 and V-ATPase Subunit H. These results demonstrate that it is a practical way to develop pesticides targeting at H subunit of V-ATPase.
Yang, Chaofu,Li, Xiaoting,Wei, Jielu,Zhu, Feng,Gang, Fangli,Wei, Shaopeng,Zhao, Yunlong,Zhang, Jiwen,Wu, Wenjun
supporting information
p. 3164 - 3167
(2018/09/11)

Poly-β-cyclodextrin based platform for pH mapping via a ratiometric 19F/1H MRI method
The in vitro validation of a new pH mapping MRI method based on a supramolecular poly-β-cyclodextrin-19F-Gd adduct is reported.
Gianolio, Eliana,Napolitano, Roberta,Fedeli, Franco,Arena, Francesca,Aime, Silvio
supporting information; experimental part
p. 6044 - 6046
(2010/11/03)

1-arylsulfonyl-2-(Pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs
New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
Shin, Jai Moo,Sachs, George,Cho, Young-Moon,Garst, Michael
experimental part
p. 5247 - 5280
(2010/03/30)

Process for preparing isomerically pure prodrugs of proton pump inhibitors
Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and experimental description.
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Page/Page column 13

(2010/02/10)

PRODRUGS OF PROTON PUMP INHIBITORS
Prodrugs of proton pump inhibitors of Formulas 1 through 4, (I-IV), where the symbols are as defined in the specification, and the R group includes at least one acidic group or its pharmaceutically acceptable salt, have improved aqueous solubility and bioavailability.
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Page 173

(2010/02/06)