Welcome to LookChem.com Sign In|Join Free

CAS

  • or
2-Chloro-6-fluorobenzyl alcohol is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

56456-50-9 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 56456-50-9 Structure
  • Basic information

    1. Product Name: 2-Chloro-6-fluorobenzyl alcohol
    2. Synonyms: LABOTEST-BB LT00053462;2-CHLORO-6-FLUOROBENZYL ALCOHOL;(2-CHLORO-6-FLUOROPHENYL)METHANOL;6-FLUORO-2-CHLOROBENZYL ALCOHOL;RARECHEM AL BD 0020;Benzenemethanol, 2-chloro-6-fluoro-;2-chloro-6-fluorobenzylic alcohol;2-Fluoro-6-chlorobenzylalcohol
    3. CAS NO:56456-50-9
    4. Molecular Formula: C7H6ClFO
    5. Molecular Weight: 160.57
    6. EINECS: 260-192-9
    7. Product Categories: Benzhydrols, Benzyl & Special Alcohols;Alcohol;Alcohols;Chlorine Compounds;Fluorine Compounds;Fluorine series
    8. Mol File: 56456-50-9.mol
  • Chemical Properties

    1. Melting Point: 40-43 °C(lit.)
    2. Boiling Point: 160°C (rough estimate)
    3. Flash Point: >230 °F
    4. Appearance: WHITE SOLID, POWDER OR CRYSTALS AND/OR
    5. Density: 1.2780 (estimate)
    6. Vapor Pressure: 0.0434mmHg at 25°C
    7. Refractive Index: 1.542
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 13.51±0.10(Predicted)
    11. BRN: 1938353
    12. CAS DataBase Reference: 2-Chloro-6-fluorobenzyl alcohol(CAS DataBase Reference)
    13. NIST Chemistry Reference: 2-Chloro-6-fluorobenzyl alcohol(56456-50-9)
    14. EPA Substance Registry System: 2-Chloro-6-fluorobenzyl alcohol(56456-50-9)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 37/39-26
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 56456-50-9(Hazardous Substances Data)

56456-50-9 Usage

Chemical Properties

White crystalline solid

Check Digit Verification of cas no

The CAS Registry Mumber 56456-50-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,4,5 and 6 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 56456-50:
(7*5)+(6*6)+(5*4)+(4*5)+(3*6)+(2*5)+(1*0)=139
139 % 10 = 9
So 56456-50-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClFO/c8-6-2-1-3-7(9)5(6)4-10/h1-3,10H,4H2

56456-50-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A11978)  2-Chloro-6-fluorobenzyl alcohol, 97%   

  • 56456-50-9

  • 5g

  • 251.0CNY

  • Detail
  • Alfa Aesar

  • (A11978)  2-Chloro-6-fluorobenzyl alcohol, 97%   

  • 56456-50-9

  • 25g

  • 964.0CNY

  • Detail
  • Alfa Aesar

  • (A11978)  2-Chloro-6-fluorobenzyl alcohol, 97%   

  • 56456-50-9

  • 100g

  • 2660.0CNY

  • Detail

56456-50-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloro-6-fluorobenzyl alcohol

1.2 Other means of identification

Product number -
Other names Benzenemethanol, 2-chloro-6-fluoro-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:56456-50-9 SDS

56456-50-9Relevant articles and documents

Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor

Li, Yali,Huang, Taomin,Lou, Bin,Ye, Deyong,Qi, Xiangyu,Li, Xiaoxia,Hu, Shuang,Ding, Tingbo,Chen, Yan,Cao, Yang,Mo, Mingguang,Dong, Jibin,Wei, Min,Chu, Yong,Li, Huiti,Jiang, Xian-Cheng,Cheng, Nengneng,Zhou, Lu

supporting information, p. 864 - 882 (2019/01/04)

The sphingomyelin synthase 2 (SMS2) is a potential target for pharmacological intervention in atherosclerosis. However, so far, few selective SMS2 inhibitors and their pharmacological activities were reported. In this study, a class of 2-benzyloxybenzamides were discovered as novel SMS2 inhibitors through scaffold hopping and structural optimization. Among them, Ly93 as one of the most potent inhibitors exhibited IC50 values of 91 nM and 133.9 μM against purified SMS2 and SMS1 respectively. The selectivity ratio of Ly93 was more than 1400-fold for purified SMS2 over SMS1. The in vitro studies indicated that Ly93 not only dose-dependently diminished apoB secretion from Huh7 cells, but also significantly reduced the SMS activity and increased cholesterol efflux from macrophages. Meanwhile, Ly93 inhibited the secretion of LPS-mediated pro-inflammatory cytokine and chemokine in macrophages. The pharmacokinetic profiles of Ly93 performed on C57BL/6J mice demonstrated that Ly93 was orally efficacious. As a potent selective SMS2 inhibitor, Ly93 significantly decreased the plasma SM levels of C57BL/6J mice. Furthermore, Ly93 was capable of dose-dependently attenuating the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice treated with Ly93. In conclusion, we discovered a novel selective SMS2 inhibitor Ly93 and demonstrated its anti-atherosclerotic activities in vivo. The preliminary molecular mechanism-of-action studies revealed its function in lipid homeostasis and inflammation process, which indicated that the selective inhibition of SMS2 would be a promising treatment for atherosclerosis.

RORγ MODULATORS

-

Page/Page column 21; 38, (2018/04/13)

The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists

Doebelin, Christelle,Patouret, Rémi,Garcia-Ordonez, Ruben D.,Chang, Mi Ra,Dharmarajan, Venkatasubramanian,Kuruvilla, Dana S.,Novick, Scott J.,Lin, Li,Cameron, Michael D.,Griffin, Patrick R.,Kamenecka, Theodore M.

supporting information, p. 2607 - 2620 (2016/12/09)

The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (TH17) cell proliferation. As such, synthetic small-molecule repressors (inverse agonists) targeting RORγ have been extensively studied for their potential as therapeutic agents for various autoimmune diseases. Alternatively, enhancing TH17 cell proliferation through activation (agonism) of RORγ may boost an immune response, thereby offering a potentially new approach in cancer immunotherapy. Herein we describe the development of N-arylsulfonyl indolines as RORγ agonists. Structure–activity studies reveal a critical linker region in these molecules as the major determinant for agonism. Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) analysis of RORγ–ligand complexes help rationalize the observed results.

Synthesis of structurally diverse diarylketones through the diarylmethyl sp3 C-H oxidation

He, Chao,Zhang, Xiaohui,Huang, Ruofeng,Pan, Jing,Li, Jiaqiang,Ling, Xuege,Xiong, Yan,Zhu, Xiangming

supporting information, p. 4458 - 4462 (2014/08/05)

Under open-flask conditions, an efficient method to assemble a series of diversely functionalized diarylketones in the presence of commercially available NBS has been developed. Yields of up to 99% have been achieved employing diarylmethanes as starting material. Based on 18O-labeled experiment, the addition of stoichiometric water eventually leads to excellent yields in all carbonylation cases.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 56456-50-9