- PIKFYVE KINASE INHIBITORS
-
The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.
- -
-
Page/Page column 226-227
(2021/08/20)
-
- The application of disubstituted vinylogous iminium salts and related synthons to the regiocontrolled preparation of unsymmetrical 2,3,4- trisubstituted pyrroles
-
Reactions of 2,3-disubstituted chloropropeniminium salts and related synthons with ethyl glycinate, ethyl N-methylglycinate, and ethyl N- benzylglycinate have been studied under acidic, basic and neutral conditions. Such reactions have resulted in efficient and selective methodology for the synthesis of unsymmetrical 2,3,4-trisubstituted pyrrole systems.
- Gupton, John T.,Krumpe, Keith E.,Burnham, Bruce S.,Dwornik, Kate A.,Petrich, Scott A.,Du, Karen X.,Bruce, Marc A.,Vu, Phong,Vargas, Marian,Keertikar, Kartik M.,Hosein, Kirsten N.,Jones, Claude R.,Sikorski, James A.
-
p. 5075 - 5088
(2007/10/03)
-
- STUDY OF THE ESCHENMOSER SULFIDE CONTRACTION METHOD WITH AND WITHOUT A THIOPHILE
-
Results obtained and observations made by applying the title method for the synthesis of enaminones 5a-o, using triphenylphosphine as a thiophile and triethylamine as a base, are reported.The product distributions of the deprotonations of α-phenacylthio iminium bromides with and without thiophile and those known from thiouronium and heterocyclic thionium analogs are compared.Key words: Enaminones; α-phenacylthio iminium bromides; disulfides; thiiranes.
- Corsaro, A.,Perrini, G.,Testa, M. G.,Chiacchio, U.
-
p. 197 - 206
(2007/10/02)
-
- Reaction of Singlet Oxygen with Enamino Carbonyl Systems. A General Method for the Synthesis of α-Keto Derivatives of Lactones, Esters, Amides, Lactams, and Ketones
-
A general method for the introduction of a ketone α to the carbonyl group of a ketone, lactone. ester, substituted amide, or lactam has been developed involving the formation and dye-sensitized photooxygenation of enamino carbonyl intermediates.
- Wasserman, Harry H.,Ives, Jeffrey L.
-
p. 3573 - 3580
(2007/10/02)
-