57584-97-1

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 93-55-0 1-phenyl-propan-1-one 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 124-40-3 dimethyl amine 
• 145930-98-9 Dimethyl-(1-methyl-2-oxo-2-phenyl-ethylsulfanylmethylene)-ammonium; bromide 
• 5815-08-7 tert-Butoxybis(dimethylamino)methane 

Downstream Products

• 208529-48-0 ethyl 1,4-dimethyl-3-phenyl-1H-pyrrole-2-carboxylate 
• 125031-48-3 Methyl 1,2-Dihydro-5-methyl-2-oxo-6-phenyl-3-pyridinecarboxylate 
• 76312-36-2 Dimethyl-(5-methyl-2,2-dioxo-6-phenyl-3,4-dihydro-2H-2λ⁶-[1,2]oxathiin-4-yl)-amine 
• 579-07-7 1-Phenylpropane-1,2-dione 
• 76312-41-9 3-Chloro-4-dimethylamino-5-methyl-6-phenyl-pyran-2-one 
• 20739-04-2 6-Methyl-7-phenylpyrido<2,3-d>pyrimidin-2,4-diamin 
• 19847-64-4 2-methyl-1-phenylbut-2-en-1-one 
• 35811-93-9 3-chloro-2-methylcinnamaldehyde 

Relevant academic research and scientific papers

PIKFYVE KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.

The application of disubstituted vinylogous iminium salts and related synthons to the regiocontrolled preparation of unsymmetrical 2,3,4- trisubstituted pyrroles

Reactions of 2,3-disubstituted chloropropeniminium salts and related synthons with ethyl glycinate, ethyl N-methylglycinate, and ethyl N- benzylglycinate have been studied under acidic, basic and neutral conditions. Such reactions have resulted in efficient and selective methodology for the synthesis of unsymmetrical 2,3,4-trisubstituted pyrrole systems.

STUDY OF THE ESCHENMOSER SULFIDE CONTRACTION METHOD WITH AND WITHOUT A THIOPHILE

Results obtained and observations made by applying the title method for the synthesis of enaminones 5a-o, using triphenylphosphine as a thiophile and triethylamine as a base, are reported.The product distributions of the deprotonations of α-phenacylthio iminium bromides with and without thiophile and those known from thiouronium and heterocyclic thionium analogs are compared.Key words: Enaminones; α-phenacylthio iminium bromides; disulfides; thiiranes.

Reaction of Singlet Oxygen with Enamino Carbonyl Systems. A General Method for the Synthesis of α-Keto Derivatives of Lactones, Esters, Amides, Lactams, and Ketones

A general method for the introduction of a ketone α to the carbonyl group of a ketone, lactone. ester, substituted amide, or lactam has been developed involving the formation and dye-sensitized photooxygenation of enamino carbonyl intermediates.