582300-87-6Relevant articles and documents
ANTIOXIDANT POLYMERS CONTAINING [1,2]-DITHIOLANE MOIETIES AND USES THEREOF
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Page/Page column 53, (2008/12/07)
The present invention describes polymers containing 1,2-dithiolanes capable of acting as scavengers of free radicals, metals and reactive oxygen species. Also described are methods of synthesizing the antioxidant 1,2-dithiolane derivatives and polymerization thereof to produce biodegradable antioxidant polymers. The antioxidant polymers of the present invention may be used to treat diseases or conditions caused by oxidative stress and other free radical mediated conditions. The antioxidant polymers may also be used for the preparation of antioxidant particulate delivery devices of therapeutic agents.
Synthesis of functionalised derivatives of pentaerythritol
Ashry, E. S. H. El,Kilany, Y. El,Hamid, H. Abdel,El-Zemity, S. R.,Boghdady, S.
, p. 111 - 128 (2007/10/03)
Ring opening of the dibenzylidene derivative of pentaerythritol 12 with N-bromosuccinimide gave di-O-benzoyldibromodideoxypentaerythritol (29). Reaction of 20 and 21 with hydrogen bromide in acetic acid afforded di-O-acetyl-di-O-p-toluenesulfonyl pentaerythritol (26). Nucleophilic displacement of the tosyloxy groups in 20 by 1,2,4 triazole afforded 2-phenyl-5-(p-toluenesulfonyloxymethyl)-5-(1,2,4-triazolylmethyl)-1,3-dioxan (31) and 2-phenyl-5,5-bis(1,2,4-triazolylmethyl)-1,3-dioxan (32), and with benzotriazole gave 2-phenyl-5,5-bis(benzotriazolylmethyl)-1,3-dioxan (30). The activity of various derivatives against hepatitis B virus has been studied.