MRI sensing of neurotransmitters with a crown ether appended Gd3+ complex
Molecular magnetic resonance imaging (MRI) approaches that detect biomarkers associated with neural activity would allow more direct observation of brain function than current functional MRI based on blood-oxygen-level-dependent contrast. Our objective wa
A substituted triaza crown ether as a binding site in DNA conjugates
Synthesis of an asymmetrically substituted triaza crown ether, its incorporation into the 3′-end and 5′-end of nine-mer oligonucleotides, and the influence of various alkanediamine ligands on duplex thermostabilities are reported.
Synthesis of an asymmetrically substituted AZA crown ether as metal and amino acid binding site in DNA conjugates
Crown ether 4 as a receptor core for protonated primary amines such as amino acids has been synthesized and incorporated into oligodeoxynucleotides as dangling ends.