59468-07-4

Basic information

• Product Name: 5,6-Dihydro Midazolam
• Synonyms: 5,6-Dihydro Midazolam;8-chloro-6-(2-fluorophenyl)-1-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine
• CAS NO: 59468-07-4
• Molecular Formula: C₁₈H₁₅ClFN₃
• Molecular Weight: 327.7832032
• Product Categories: Aromatics;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 59468-07-4.mol

Chemical Properties

• Melting Point: 205-207°C
• Boiling Point: 465.8±55.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• Storage Temp.: Controlled Substance, -20?C Freezer
• PKA: 6.82±0.40(Predicted)
• CAS DataBase Reference: 5,6-Dihydro Midazolam(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-Dihydro Midazolam(59468-07-4)
• EPA Substance Registry System: 5,6-Dihydro Midazolam(59468-07-4)

Safety Data

• Hazardous Substances Data: 59468-07-4(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Midazolam

Upstream product

• 59469-74-8 8-chloro-6-(2-fluorophenyl)-1-methyl-6H-imidazo<1,5-a><1,4>benzodiazepine 
• 67-63-0 isopropyl alcohol 
• 59469-30-6 1-acetyl-2-(acetylamino-methyl)-7-chloro-5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine 
• 59467-64-0 (7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methanamine 
• 59468-83-6 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-oxide 
• 59469-08-8 8-chloro-6-(2-fluoro-phenyl)-1-methyl-3a,4,5,6-tetrahydro-3H-benzo[f]imidazo[5,1-a][1,4]diazepine 
• 59467-69-5 8-chloro-6-(2-fluoro-phenyl)-1-methyl-3a,4-dihydro-3H-benzo[f]imidazo[1,5-a][1,4]diazepine 
• 59469-03-3 8-chloro-6-(2-fluorophenyl)-1-hydroxy-methyl-4H-imidazo(1,5-a)(1,4)-benzodiazepine 
• 59467-70-8 Midazolam 

Downstream Products

• 59469-05-5 5-allyl-8-chloro-6-(2-fluoro-phenyl)-1-methyl-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine 
• 59469-01-1 8-chloro-6-(2-fluoro-phenyl)-1-methyl-5-(toluene-4-sulfonyl)-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine 
• 59469-06-6 5-acetyl-8-chloro-6-(2-fluoro-phenyl)-1-methyl-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine 
• 59469-02-2 8-chloro-6-(2-fluoro-phenyl)-1-methyl-5-nitroso-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine 
• 59469-04-4 8-chloro-6-(2-fluoro-phenyl)-1,5-dimethyl-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine 

Relevant articles and documents

Apparent proton-catalyzed Meerwein-Ponndorf-Verley type reduction of 8-chloro-6-(2-fluorophenyl)-1-methyl-6H-imidazo[1,5-a][1,4]benzodiazep ine

When treated with 2-propanol in the presence of HCl, reduction of the C4-N double bond in 8 chloro-6-(2-fluorophenyl)-1-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin e occurs. Data are presented which indicate 2-propanol is the reductant in a two-step mechanism.

Imidazodiazepines and processes therefor

Novel Imidazobenzodiazepines and their analogs are useful as anticonvulsants, muscle relaxant, anxiolytic and sedative agents. Preferred compounds of this class belong to the imidazo[1,5-a][1,4]diazepine series which may have a very wide variety of organic substituents. An especially preferred genus included within the purview of the invention encompasses a compound of the formula STR1 wherein R1 is hydrogen and lower alkyl preferably methyl; R3 and R5 are hydrogen; R4 is hydrogen, nitro and halogen, most preferably, chlorine, and in a most preferred embodiment when positioned on the fused benzo portion of the imidazobenzodiazepine is in the 8-position thereof, R6 is phenyl or halo, nitro, or lower alkyl-substituted phenyl, preferably, halo, with fluorine being the preferred halogen, the substituted fluoro being positioned in the 2-position of the phenyl moiety and R2 is hydrogen and lower alkyl.