594839-90-4

Basic information

• Product Name: 2-PHENYLBENZO[D]OXAZOLE-6-CARBOXYLIC ACID
• Synonyms: 2-PHENYLBENZO[D]OXAZOLE-6-CARBOXYLIC ACID;2-phenyl-6-benzoxazolecarboxylic acid
• CAS NO: 594839-90-4
• Molecular Formula: C₁₄H₉NO₃
• Molecular Weight: 239.22616
• Mol File: 594839-90-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-PHENYLBENZO[D]OXAZOLE-6-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYLBENZO[D]OXAZOLE-6-CARBOXYLIC ACID(594839-90-4)
• EPA Substance Registry System: 2-PHENYLBENZO[D]OXAZOLE-6-CARBOXYLIC ACID(594839-90-4)

Safety Data

• Hazardous Substances Data: 594839-90-4(Hazardous Substances Data)

Usage

Uses

Used in Scientific Research:
2-Phenylbenzo[d]oxazole-6-carboxylic acid is used as a fluorescent dye for various applications in scientific research, such as fluorescence microscopy, flow cytometry, and fluorescent tagging of biological molecules. Its fluorescent properties make it a valuable tool for visualizing and studying cellular processes and interactions.
Used in Environmental Monitoring:
2-Phenylbenzo[d]oxazole-6-carboxylic acid is studied for its potential as a fluorescent probe for sensing environmental pollutants. Its ability to detect and quantify contaminants can contribute to environmental protection and monitoring efforts.
Used in Organic Light-Emitting Diodes (OLEDs):
2-Phenylbenzo[d]oxazole-6-carboxylic acid is also considered as a component in organic light-emitting diodes. Its fluorescent characteristics can enhance the performance and efficiency of OLEDs, which are used in various display and lighting applications.

Upstream product

• 100-52-7 benzaldehyde 
• 63435-16-5 3-hydroxy-4-aminobenzoic acid methyl ester 
• 2374-03-0 4-aminosalicylic acid 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 98-88-4 benzoyl chloride 
• 136663-22-4 methyl 2-phenylbenzo[d]oxazole-6-carboxylate 

Downstream Products

• 1393746-69-4 C₂₈H₃₁N₃O₃ 
• 1373356-10-5 2-phenyl-6-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1,3-benzoxazole 
• 136663-22-4 methyl 2-phenylbenzo[d]oxazole-6-carboxylate 

Relevant articles and documents

PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R are defined herein.

Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors

A new class of benzoxazole and benzothiazole amide derivatives exhibiting potent CYP3A4 inhibiting properties was identified. Extensive lead optimization was aimed at improving the CYP3A4 inhibitory properties as well as overall ADME profile of these amide derivatives. This led to the identification of thiazol-5-ylmethyl (2S,3R)-4-(2-(ethyl(methyl)amino)-N-isobutylbenzo[d]oxazole- 6-carboxamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate (C1) as a lead candidate for this class. This compound together with structurally similar analogues demonstrated excellent 'boosting' properties when tested in dogs. These findings warrant further evaluation of their properties in an effort to identify valuable alternatives to Ritonavir as pharmacokinetic enhancers.

DI-AZETIDINYL DIAMIDE AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Q and Z are defined herein.

OXOPIPERAZINE-AZETIDINE AMIDES AND OXODIAZEPINE-AZETIDINE AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (Ia) and Formula (Ib) as follows: wherein Y, Z, and n are defined herein; and wherein Yb and Zb are as defined herein.

AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I), wherein Y, Z, R1, and s are defined herein.

Benzoxazoles as transthyretin amyloid fibril inhibitors: Synthesis, evaluation, and mechanism of action

Benzoxazoles pevent misfolding: Benzoxazole-based inhibitors of transthyretin (TTR) amyloid fibril formation are among the most effective found to date. They stabilize TTR against both acid-mediated misfolding and urea denaturation by raising the activati