- In Situ Preparation and Consumption of O -Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines
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The paper demonstrates a safe method in which highly unstable O -mesitylsulfonylhydroxylamine (MSH) can be prepared and consumed in continuous flow. MSH was prepared in situ and used for the flow amination of a range of pyridines, which were subsequently transformed into useful pyrazolopyridine building blocks.
- Brocklehurst, Cara E.,Koch, Guido,Rothe-P?llet, Stephanie,La Vecchia, Luigi
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supporting information
p. 1636 - 1640
(2017/08/11)
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- Functionally selective dopamine D2, D3 receptor partial agonists
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Dopamine D2 receptor-promoted activation of Gαo over Gαi may increase synaptic plasticity and thereby might improve negative symptoms of schizophrenia. Heterocyclic dopamine surrogates comprising a pyrazolo[1,5-a]pyridine
- M?ller, Dorothee,Kling, Ralf C.,Skultety, Marika,Leuner, Kristina,Hübner, Harald,Gmeiner, Peter
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supporting information
p. 4861 - 4875
(2014/07/07)
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- PYRAZOLOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS
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This invention relates to pyrazolopyridyl compounds of the structural formula: [Formula should be inserted here] or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone s
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Page/Page column 54
(2013/04/10)
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- Indolizines and aza-analog derivatives thereof as CNS active compounds
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Presently disclosed are indolicine-based compounds of the general formula which have medical utility, for example as antipsychotics.
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Page/Page column 31
(2008/12/08)
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- N- and O-substituted aminophenols, method and use for diagnosis
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The present invention provides N- and O-substituted aminophenol derivatives of the general formula STR1 wherein R1, R2, R3, G and L are as hereinbefore defined. The present invention also provides intermediates for the preparation of these aminophenol derivatives of general formula (I), as well as the use of the aminophenol derivatives of general formula (I) for the determination of hydrolyses, as well as for the preparation of agents for carrying out determinations of hydrolyses.
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