60388-53-6

Basic information

• Product Name: DL-Amethopterin hydrate
• Synonyms: DL-4-Amino-N10-methylpteroylglutamic acid; (plus-minus)-amethopterin
• CAS NO: 60388-53-6
• Molecular Formula: C₂₀H₂₂N₈O₅
• Molecular Weight: 454.445
• EINECS: 262-213-7
• Product Categories: RHEUMATREX
• Mol File: 60388-53-6.mol

Chemical Properties

• Melting Point: 195℃
• Density: 1.536±0.06 g/cm3(Predicted)
• Storage Temp.: ?20°C
• Solubility: H2O: Add a minimal amount of 0.1燦 NaOH to solubilize, then dilute in neutral buffer or saline. Diluted stock is stable for 1爓eek refrigerated and for 1爉onth frozen at?#8722;20?#x00b0;C.insoluble
• PKA: 3.47±0.10(Predicted)
• CAS DataBase Reference: DL-Amethopterin hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: DL-Amethopterin hydrate(60388-53-6)
• EPA Substance Registry System: DL-Amethopterin hydrate(60388-53-6)

Safety Data

• Hazard Codes: T:Toxic
• Statements: R46:May cause heritable genetic damages.; R61:May cause harm to the unborn child.
• Safety Statements: S45:In case of accident of if you feel unwell, seek medical advice immediately (show the label where possible).; S53:Avoi
• RIDADR: UN 1544 6.1/PG 2
• WGK Germany: 3
• RTECS: MA1224100
• Hazardous Substances Data: 60388-53-6(Hazardous Substances Data)

Usage

Uses

Used in Oncology:
DL-Amethopterin hydrate is used as an antineoplastic agent for the treatment of various types of cancer. It works by inhibiting the activity of dihydrofolate reductase, an enzyme involved in the synthesis of DNA and RNA, thereby preventing the growth and proliferation of cancer cells.
Used in Rheumatology:
DL-Amethopterin hydrate is used as an antirheumatic agent for the treatment of various inflammatory and autoimmune conditions, such as rheumatoid arthritis, psoriasis, and lupus. It helps to reduce inflammation and alleviate symptoms associated with these conditions.
Used in Pharmaceutical Industry:
DL-Amethopterin hydrate is used as a folic acid antagonist in the development of pharmaceutical drugs for the treatment of cancer and autoimmune diseases. Its unique properties make it a valuable component in the formulation of medications that target specific cellular processes and pathways.

Downstream Products

• 59-05-2 (+)-amethopterin 
• 7413-34-5 methotrexate disodium salt 
• 112163-39-0 7-cyanomethotrexate dimethyl ester 
• 5939-37-7 (+/-)-7-hydroxymethotrexate 
• 34378-65-9 methotrexate dimethyl ester 

Relevant articles and documents

Enantioseparation using cyclosophoraoses as a novel chiral additive in capillary electrophoresis

Cyclosophoraoses, cyclic β-(1→2)-D-glucans produced by Rhizobium meliloti 2011, were used as a novel chiral additive for the separation of terbutaline, amethopterin, thyroxine and N-acetylphenylalanine enantiomers in aqueous capillary electrophoresis (CE). Enantioseparation took place in the normal- or reversed-polarity mode when a high concentration of neutral (60 mM) or anionic (40 mM) cyclosophoraoses was added to the background electrolyte (BGE).

Folic acid antagonists. Methotrexate analogs containing spurious amino acids. Dichlorohomofolic acid

The synthesis and some biological testing results are reported for dichlorohomofolic acid (2a) and 3 methotrexate (MTX) analogs in which the L glutamic acid moiety was replaced by D glutamic acid, glutaric acid, and L lysine to give 4b, 4c, and 4d, respec