cas 60402-29-1, 1-(4-CHLOROPHENYL)-3-(2-HYDROXY-5-METHYLPHENYL)PROPANE-1,3-DIONE

Articles about 60402-29-1Total 2 be found

Investigation on the substitution effects of the flavonoids as potent anticancer agents: A structure-activity relationships study
Three series of flavonoid analogues substituted with different aminomethyl substitutions at C-6, C-7, and C-8 were designed and synthesized for the structure-activity relationship studies as potent anticancer agents. The prepared analogues were evaluated for their in vitro inhibitory activity against the growth of the hepatic cancer cell lines HepG2 and SMMC-7721. Structure-activity relationships indicated that not only the compounds with amino methyl groups were more active than those without the groups in the same series but also the compounds substituted by aminomethyl groups at position C-8 were more active than those at positions C-6 and C-7.
Wang, Xiao-Bing,Yang, Lei,Kong, Ling-Yi,Liu, Wei,Guo, Qing-Long
p. 1833 - 1849,17
(2020/07/30)

Epoxidation of Flavones by Dimethyldioxirane
The synthesis of epoxides 2 by epoxidation of flavones 1 with isolated dimethyldioxirane (as acetone solution) at subambient temperatures is reported.These labile epoxides were isolated and completely characterized by UV, IR, 1H and 13C NMR, MS, and C,H analyses.Warming to room temperature led to rearrangement to afford quantitatively the 3-hydroxyflavones 3b,h,i,n.Treatment of the epoxides 2b,f with methanol led to the 3-hydroxy-2-methoxyflavanones 4b,f, as a mixture of cis and trans isomers.
Adam, Waldemar,Golsch, Dieter,Hadjiarapoglou, Lazaros
p. 7292 - 7297
(2007/10/02)