60454-99-1

Basic information

• Product Name: 1-butoxy-1H-benzotriazole
• CAS NO: 60454-99-1
• Molecular Formula: C₁₀H₁₃N₃O
• Molecular Weight: 191.2297
• Mol File: 60454-99-1.mol

Chemical Properties

• Boiling Point: 292.9°C at 760 mmHg
• Flash Point: 131°C
• Density: 1.17g/cm³
• Vapor Pressure: 0.00178mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 1-butoxy-1H-benzotriazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-butoxy-1H-benzotriazole(60454-99-1)
• EPA Substance Registry System: 1-butoxy-1H-benzotriazole(60454-99-1)

Safety Data

• Hazardous Substances Data: 60454-99-1(Hazardous Substances Data)

Usage

Benzotriazole derivative

A chemical compound derived from benzotriazole, which serves as the base structure for this substance.

Corrosion inhibitor

Effectively protects metals from corrosion and oxidation by forming a thin, protective barrier on the metal surface.

Application in metalworking fluids

Commonly used in metalworking fluids to prevent corrosion and extend the life of metal tools and machinery.

Stabilizer for organic coatings

Utilized in inks, adhesives, and other organic coatings to prevent degradation and maintain the integrity of the material.

Use in cleaning products

Incorporated in cleaning products to enhance their effectiveness in removing dirt, grease, and other contaminants.

UV stabilizer

Employed in plastics and rubber to protect against damage caused by exposure to ultraviolet (UV) radiation.

Low toxicity

Considered to have low toxicity, but proper handling and safety measures are still recommended when working with this substance.

Upstream product

• 109-65-9 1-bromo-butane 
• 2592-95-2 benzotriazol-1-ol 

Relevant articles and documents

Synthesis and evaluation of 1-hydroxybenzotriazole derivatives: Dual inhibitors of carbonic anhydrase ii and sodium hydrogen exchanger i

Ischemia reperfusion injury is responsible for impaired graft functioning in organ transplants, cerebral dysfunction, ischemic heart diseases, systemic inflammatory response syndrome, gastrointestinal dysfunction, and multiple organ dysfunction syndromes. Intracellular pH is critical for cell survival in ischemia reperfusion injury. Sodium hydrogen exchanger I and carbonic anhydrase II are critical in the regulation of intracellular pH. Inhibition of sodium hydrogen exchanger I and carbonic anhydrase II during reperfusion is found to ameliorate ischemia reperfusion injury separately. An attempt is made to synthesize dual inhibitors of sodium hydrogen exchanger and carbonic anhydrase to have better potential drug molecule in ischemia reperfusion injury treatment. The hydroxybenzotriazole is considered as a central pharmacophore for this dual activity and 12 derivatives are synthesized. All derivatives are tested for sodium hydrogen exchanger I and carbonic anhydrase II inhibitory activity. The tosylate derivative (12) is found to be the most potent derivative with IC50 158.7± 8.4 μM for carbonic anhydrase II and 31.07 ± 1.06 μM for sodium hydrogen exchanger I. Although the potency is less than standard drugs but this is the first report of dual inhibitor of carbonic anhydrase II and sodium hydrogen exchanger.

Design, synthesis and antidepressant and anticonvulsant effect of 1-alkoxy-1H-benzo[d]-1,2,3-triazole derivatives

21 novel 1-alkoxy-1H-benzo[d]-1,2,3-triazole compounds were designed, prepared and evaluated for their antidepressant and anticonvulsant effects in mice. Compound 19 significantly decreased immobility time in the FST without altering the locomotor activit