60575-19-1Relevant articles and documents
POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF
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Page/Page column 116; 117, (2014/09/29)
Certain aspects of the invention relate to small molecule autophagy inhibitors, and their use for treatment and prevention of cancers and acute pancreatitis. Medicinal chemistry studies led to small molecular autophagy inhibitors with improved potency and selectivity.
ANTAGONISTS OF THE TRPV1 RECEPTOR AND USES THEREOF
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Page/Page column 13, (2008/12/06)
The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.
Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof
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Page/Page column 23, (2008/06/13)
Compounds that are antagonists of the VR1 receptor, having formula (I) [image] or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.
Centrally acting 6,7,8,9-tetrahydro-3H-benz(E)indole heterocyclics
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, (2008/06/13)
A compound of Formula I STR1 or pharmaceutically acceptable salts of Formula I, where R1 is H, C1 -C3 alkyl, --(CH2)n CONH2 where n is 2 to 6, (CH2)n -1-(4,4-dimethylpiperidine-2
3,4-Dihydro-3-amino-2H-1-benzopyran Derivatives as 5-HT1A Receptor Ligands and Potential Anxiolytic Agents. 1. Synthesis and Structure-Activity Relationship Studies
Podona, Tchao,Guardiola-Lemaitre, Beatrice,Caignard, Daniel-Henri,Adam, Gerard,Pfeiffer, Bruno,et al.
, p. 1779 - 1793 (2007/10/02)
A series of 3,4-dihydro-3-amino-2H-1-benzopyran derivatives were prepared in order to determine the necessary structural requirements for good affinity for 5-HT1A receptors and high selectivity versus other receptors.Modifications of the extrac
Centrally acting 6,7,8,9-tetrahydro-3H-benz(e)indole heterocyclics
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, (2008/06/13)
A compound of Formula I STR1 or pharmaceutically acceptable salts of Formula I, where R 1 is H, C 1 -C 3 alkyl, --(CH 2) n CONH 2 where n is 2 to 6, (CH2) n -1-(4,4-dimethylpiperidine-2,6-dione-yl), or cyclopropylmethyl;R 2 is hydrogen, C 1 -C 8 alkyl, C