cas 60736-71-2, 4-METHOXY-3-METHYLBENZYL CHLORIDE | Articles data ｜lookchem

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60736-71-2

Articles about 60736-71-2Total 6 be found

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PYRIMIDINE COMPOUNDS CONTAINING ACIDIC GROUPS
The present disclosure relates to a class of pyrimidine derivatives having immunomodulating properties that act via TLR7 which are useful in the treatment of viral infections and cancers.
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Paragraph 1035; 1037

(2018/06/15)

Cutting long syntheses short: Access to non-natural tyrosine derivatives employing an engineered tyrosine phenol lyase
The chemical synthesis of 3-substituted tyrosine derivatives requires a minimum of four steps to access optically enriched material starting from commercial precursors. Attempting to short-cut the cumbersome chemical synthesis of 3-substituted tyrosine derivatives, a single step biocatalytic approach was identified employing the tyrosine phenol lyase from Citrobacter freundii. The enzyme catalyses the hydrolysis of tyrosine to phenol, pyruvate and ammonium as well as the reverse reaction, thus the formation of tyrosine from phenol, pyruvate and ammonium. Since the wild-type enzyme possessed a very narrow substrate spectrum, structure-guided, site-directed mutagenesis was required to change the substrate specificity of this C-C bond forming enzyme. The best variant M379V transformed, for example, o-cresol, o-methoxyphenol and o-chlorophenol efficiently to the corresponding tyrosine derivatives without any detectable side-product. In contrast, all three phenol compounds were non-substrates for the wild-type enzyme. Employing the mutant, various Ltyrosine derivatives (3-Me, 3-OMe, 3-F, 3-Cl) were obtained with complete conversion and excellent enantiomeric excess (>97%) in just a single 'green' step starting from pyruvate and commercially available phenol derivatives.
Seisser, Birgit,Zinkl, Rene,Gruber, Karl,Kaufmann, Franz,Hafner, Andreas,Kroutil, Wolfgang
supporting information; experimental part
p. 731 - 736
(2010/06/21)

Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
The present invention provides a compound of formula (1) wherein R1-R5, R25, R26, Y and X2 are defined as in claim 1. The compounds activate human peroxisome proliferator activated receptors (hPPARs) and arc useful for the treatment of associated disorders such as cardiovascular disease and hypercholesteremia.
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(2008/06/13)

Total synthesis refutes the postulated structure of leucogenenol
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Salomon,Salomon,Zagorski,et al.
p. 1008 - 1013
(2007/10/02)

Substituted benzyloxyarylacetic acids: synthesis and quantitative relationships between structure and antiinflammatory activity
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Kuchar,Brunova,Rejholec,et al.
p. 1723 - 1735
(2007/10/05)

Methyl-substituted tyrosines and realted compunds as potential anticancer agents.
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JORGENSEN,WILEY
p. 122 - 125
(2007/10/06)

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Chemical Properties

Boiling Point: 143°C 25mm
Flash Point:104.5°C
Density: 1,11 g/cm3
Vapor Pressure: 0.0547mmHg at 25°C
PSA: 9.23000
LogP: 2.74240

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