607362-87-8Relevant articles and documents
AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE
-
Paragraph 0443-0444, (2014/08/19)
The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
2-PHENYL-5-HETEROCYCLYL-TETRAHYDRO-2H-PYRAN-3-AMINE COMPOUNDS FOR USE IN THE TREATMENT OF DIABETES AND ITS ASSOCIATED DISORDERS
-
Page/Page column 27; 28, (2014/05/07)
The present invention relates to novel compounds of the general formula (I) their tautomeric forms, their enantiomers, their diastereoisomers, their pharmaceutically accepted salts, or pro-drugs thereof, which are useful for the treatment or prevention of diabetes mellitus (DM), obesity and other metabolic disorders. The invention also relates to process for the manufacture of said compounds, and pharmaceutical compositions containing them and their use.
AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE
-
Paragraph 00290, (2013/06/05)
The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter-and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
A New and Efficient Strategy for Non-stabilized Azomethine Ylide via Photoinduced Electron Transfer (PET) Initiated Sequential Double Desilylation
Pandey, Ganesh,Lakshmaiah, G.,Kumaraswamy, G.
, p. 1313 - 1314 (2007/10/02)
A practical approach for generating non-stabilized azomethine ylide by PTE initiation is generated.
PYRROLIDINE AND α-METHYLENE-γ-LACTAM FROM THE CYCLIZATION OF α -ALKYLAMINOETHYL)ACRYLATE: SYNTHESIS OF AZA-SARCOMYCINS
Tarnchompoo, Bonkoch,Thebtaranonth, Chachanat,Thebtaranonth, Yodhathai
, p. 6675 - 6678 (2007/10/02)
Diene 1 readily adds primary amines to give 2 which can cyclize either in a Michael addition fashion or via a displacement reaction to give, respectively, pyrrolidine 3 or methylene lactam 4 which further isomerizes to 5 under the employed reaction conditions.Compound 4 can be obtained as the sole product from the reaction of diene precursor 7 with amines followed by vacuum pyrolysis
A DEFINITE EVIDENCE ON THE AMBIVALENT AZOMETHINE YLIDE INTERMEDIATE IN TRIFLUOROACETIC ACID- AND FLUORIDE ANION-PROMOTED 1,3-CYCLOADDITIONS INVOLVING THE SILICON-CARBON BOND CLEAVAGE
Terao, Yoshiyasu,Kotaki, Hiromi,Imai, Nobuyuki,Achiwa, Kazuo
, p. 896 - 898 (2007/10/02)
Trifluoroacetic acid- and fluoride anion-promoted 1,3-cycloadditions of N-benzyl-N-(methoxymethyl)trimethylsilylmethylamine to dipolarophiles were found to proceed via the ambivalent azomethine ylide intermediates.KEYWORDS - azomethine ylide; 1,3-cycloaddition; ambivalence; N-benzyl-N-(methoxymethyl)trimethylsilylmethylamine; dipolarophile