612086-27-8Relevant articles and documents
Preparative-Scale Synthesis of Vedejs Chiral DMAP Catalysts
Kinens, Artis,Balkaitis, Simonas,Suna, Edgars
, p. 12449 - 12459 (2018/10/20)
A scalable synthesis of chiral Vedejs-type DMAP catalysts is reported. The key step of the synthesis is amination of the enantiomerically pure 4-chloropyridine derivative using well-defined ZnCl2(amine)2 complexes. A series of Zn(II)-amine complexes have been synthesized to explore the scope of the ZnCl2-mediated amination of 4-halopyridines. Mechanistic studies support a Zn(II)-facilitated nucleophilic aromatic substitution as a plausible mechanism for the chlorine-to-amine exchange.
PROCESS FOR THE PREPARATION OF ATROPISOMERIC ANALOGUES OF 4-AMINOPYRIDINE
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Page 13; 14, (2010/02/10)
The present invention relates to a process for the preparation of 3,4-disubstituted pyridines from commercially available starting materials. In particular, the invention relates to the process for the preparation for a compound of formula (I) wherein a c
Concise synthesis, preparative resolution, absolute configuration determination, and applications of an atropisomeric biaryl catalyst for asymmetric acylation
Spivey, Alan C.,Zhu, Fujiang,Mitchell, Mark B.,Davey, Stephen G.,Jarvest, Richard L.
, p. 7379 - 7385 (2007/10/03)
A new three-step synthesis and resolution of nucleophilic catalyst 1 suitable for large-scale preparation has been developed, and this catalyst has been shown to be effective for the kinetic resolution and asymmetric desymmetrization of a range of sec-alcohol substrates.