278600-44-5Relevant articles and documents
PROCESS FOR THE PREPARATION OF ATROPISOMERIC ANALOGUES OF 4-AMINOPYRIDINE
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Page 14, (2010/02/10)
The present invention relates to a process for the preparation of 3,4-disubstituted pyridines from commercially available starting materials. In particular, the invention relates to the process for the preparation for a compound of formula (I) wherein a c
Chiral catalysts for asymmetric acylation and related transformations
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, (2008/06/13)
A chiral catalyst comprising a 3,4-disubstituted pyridine, or a salt, N functionalized derivative, dimer or oligomer thereof, wherein the 3-substituent is substantially hindered from rotation about the bond (sp2-sp2 biaryl axis) link
Concise synthesis, preparative resolution, absolute configuration determination, and applications of an atropisomeric biaryl catalyst for asymmetric acylation
Spivey, Alan C.,Zhu, Fujiang,Mitchell, Mark B.,Davey, Stephen G.,Jarvest, Richard L.
, p. 7379 - 7385 (2007/10/03)
A new three-step synthesis and resolution of nucleophilic catalyst 1 suitable for large-scale preparation has been developed, and this catalyst has been shown to be effective for the kinetic resolution and asymmetric desymmetrization of a range of sec-alcohol substrates.
Axially chiral analogues of 4-(dimethylamino)pyridine: Novel catalysts for nonenzymatic enantioselective acylations
Spivey, Alan C.,Fekner, Tomasz,Spey, Sharon E.
, p. 3154 - 3159 (2007/10/03)
A concise seven-step synthesis of atropisomeric 3-aryl analogues of DMAP from 4-pyridone 8 has been developed. A representative compound of this class, biaryl (±)-15, has been resolved using CSP HPLC and shown to be an efficient nucleophilic catalyst for kinetic resolution of a series of secondary alcohols on both an analytical and preparative scale (stereoselectivity factors, s = 8.9-29).