Technology Process of Pyridine, 4-chloro-3-(2-phenyl-1-naphthalenyl)-
There total 6 articles about Pyridine, 4-chloro-3-(2-phenyl-1-naphthalenyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate;
In
toluene;
at 80 ℃;
for 72h;
Inert atmosphere;
DOI:10.1021/acs.joc.8b01687
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridine / 4 h / 0 - 20 °C
2.1: Pd2(dba)3; 1,3-bis(diphenylphosphino)propane; LiBr / diethyl ether / 7 h / 20 °C
3.1: n-BuLi / diethyl ether; hexane / 0.25 h / -78 °C
3.2: 4.04 g / diethyl ether; hexane / 3 h / -78 - 20 °C
4.1: 80 percent / silver(I) carbonate; Pd(PPh3)4 / benzene / 96 h / Heating
5.1: 99 percent / i-PrMgCl / tetrahydrofuran / 2 h / 20 °C
With
pyridine; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; tris(dibenzylideneacetone)dipalladium (0); 1,3-bis-(diphenylphosphino)propane; isopropylmagnesium chloride; silver carbonate; lithium bromide;
In
tetrahydrofuran; diethyl ether; hexane; benzene;
4.1: Suzuki reaction;
