Pyridine, 4-chloro-3-(2-phenyl-1-naphthalenyl)-

Base Information

Chemical Name:Pyridine, 4-chloro-3-(2-phenyl-1-naphthalenyl)-
CAS No.:612086-27-8
Molecular Formula:C21H14ClN
Molecular Weight:315.802
Hs Code.:
DSSTox Substance ID:DTXSID80452780
Wikidata:Q82273606

Synonyms:612086-27-8;Pyridine, 4-chloro-3-(2-phenyl-1-naphthalenyl)-;SCHEMBL6237084;DTXSID80452780

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyridine, 4-chloro-3-(2-phenyl-1-naphthalenyl)-

Chemical Property:

XLogP3:6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:315.0814771
Heavy Atom Count:23
Complexity:378

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(C3=CC=CC=C3C=C2)C4=C(C=CN=C4)Cl

Technology Process of Pyridine, 4-chloro-3-(2-phenyl-1-naphthalenyl)-

There total 6 articles about Pyridine, 4-chloro-3-(2-phenyl-1-naphthalenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 612086-26-7
(+/-)-3-bromo-4-chloro-5-(2-phenylnaphthalen-1-yl)pyridine

: 612086-27-8
4-chloro-3-(2-phenyl-naphthalen-1-yl)pyridine

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 72.0%

: 89167-34-0
4-chloro-3-iodopyridine

: 612086-25-6
4,4,5,5-tetramethyl-2-(2-phenyl-naphthalen-1-yl)-[1,3,2]dioxaborolane

: 612086-27-8
4-chloro-3-(2-phenyl-naphthalen-1-yl)pyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 80 ℃; for 72h; Inert atmosphere;
DOI:10.1021/acs.joc.8b01687

Reference yield:

: 573-97-7
1-bromo-2-naphthol

: 612086-27-8
4-chloro-3-(2-phenyl-naphthalen-1-yl)pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 4 h / 0 - 20 °C

2.1: Pd₂(dba)3; 1,3-bis(diphenylphosphino)propane; LiBr / diethyl ether / 7 h / 20 °C

3.1: n-BuLi / diethyl ether; hexane / 0.25 h / -78 °C

3.2: 4.04 g / diethyl ether; hexane / 3 h / -78 - 20 °C

4.1: 80 percent / silver(I) carbonate; Pd(PPh₃)4 / benzene / 96 h / Heating

5.1: 99 percent / i-PrMgCl / tetrahydrofuran / 2 h / 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 1,3-bis-(diphenylphosphino)propane; isopropylmagnesium chloride; silver carbonate; lithium bromide; In tetrahydrofuran; diethyl ether; hexane; benzene; 4.1: Suzuki reaction;