612825-76-0

Basic information

• Product Name: (4-Iodo-3-nitro-phenyl)-Methanol
• Synonyms: (4-Iodo-3-nitro-phenyl)-Methanol
• CAS NO: 612825-76-0
• Molecular Formula: C₇H₆INO₃
• Molecular Weight: 279.03191
• Mol File: 612825-76-0.mol

Chemical Properties

• Boiling Point: 366.4±32.0 °C(Predicted)
• Appearance: /
• Density: 2.034±0.06 g/cm3(Predicted)
• PKA: 13.49±0.10(Predicted)
• CAS DataBase Reference: (4-Iodo-3-nitro-phenyl)-Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Iodo-3-nitro-phenyl)-Methanol(612825-76-0)
• EPA Substance Registry System: (4-Iodo-3-nitro-phenyl)-Methanol(612825-76-0)

Safety Data

• Hazardous Substances Data: 612825-76-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(4-Iodo-3-nitro-phenyl)-Methanol is used as a reagent in organic synthesis for the production of various pharmaceuticals, agrochemicals, and fine chemicals. Its unique structure allows it to be a versatile building block in the synthesis of complex organic molecules.
Used in Medicinal and Biochemical Research:
Due to its potential biological activities, (4-Iodo-3-nitro-phenyl)-Methanol is used as a valuable tool in medicinal and biochemical research. Its unique chemical properties make it suitable for studying various biological processes and developing new therapeutic agents.
Used in Chemical Industry:
(4-Iodo-3-nitro-phenyl)-Methanol is used in the chemical industry for various applications, including the synthesis of dyes, pigments, and other specialty chemicals. Its unique structure and reactivity make it a useful intermediate in the production of these materials.

Upstream product

• 89976-27-2 methyl ester of 4-iodo-3-nitrobenzoic acid 
• 57362-77-3 ethyl 4-iodo-3-nitrobenzoate 
• 35674-27-2 4-iodo-3-nitrobenzoic acid 

Downstream Products

• 612825-78-2 5-(tert-butyldimethylsilyloxymethyl)-2-iodonitrobenzene 
• 612825-80-6 5-(tert-butyldimethylsilyloxymethyl)-2-iodoaniline 

Relevant articles and documents

Oxidative Approach Enables Efficient Access to Cyclic Azobenzenes

Azobenzenes are versatile photoswitches that have found widespread use in a variety of fields, ranging from photopharmacology to the material sciences. In addition to regular azobenzenes, the cyclic diazocines have recently emerged. Although diazocines have fascinating conformational and photophysical properties, their use has been limited by their synthetic accessibility. Herein, we present a general, high-yielding protocol that relies on the oxidative cyclization of dianilines. In combination with a modular substrate synthesis, it allows for rapid access to diversely functionalized diazocines on gram scales. Our work systematically explores substituent effects on the photoisomerization and thermal relaxation of diazocines. It will enable their incorporation into a wide variety of functional molecules, unlocking the full potential of these emerging photoswitches. The method can be applied to the synthesis of a new cyclic azobenzene with a nine-membered central ring and distinct properties.

Highly stereoselective 7-endo-trig /ring contraction cascade to construct pyrrolo[1,2- a ]quinoline derivatives

With the cooperation of Cram's phenonium ion, a novel cascade reaction was illustrated to construct pyrrolo[1,2-a]quinolines as a sole diastereoisomer in good to excellent yields. Preliminary mechanistic studies revealed that the γ-lactam ring and electron-rich arene are important driving forces for ring contraction.

Catalytic asymmetric synthesis of the central tryptophan residue of celogentin C

(Equation presented) Chiral phase-transfer catalyst 5 containing an electron-deficient trifluorobenzyl moiety promoted the alkylation of glycine derivative 6 with propargyl bromide 7a in good yield and excellent ee. The resulting propargyl glycine 8 was c