- SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS
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The present invention relates to substituted thiazoles, to methods for the production thereof, to medicaments containing these compounds and to the use thereof for producing medicaments.
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Page/Page column 50
(2009/07/18)
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- Synthesis and rearrangement of N-methyl-N-(2-thiazolyl)-nitramine
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Methylation of N-(2-thiazolyl)-nitramine in alkaline solution gives 1,2-dihydro-3-methyl-2-nitriminothiazole which rearranges in concentrated sulphuric acid yielding small amount of 2-(N-methylamino)-5-nitrothiazole, identical with the product of rearrangement of N-methyl-N-(2-thiazolyl)-nitramine. The latter compound was obtained by the action of sodium hydride on 2-(N-methylamino)-thiazole followed by the nitration with n-butyl nitrate.
- Daszkiewicz,Koterzyna,Kyziol
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p. 2921 - 2927
(2007/10/03)
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- N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection
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A method for treating HIV which comprises a compound of the formula STR1 wherein A is STR2 and Zi is O, Se, NRa or C(Ra)2, and Zii is --O or (=O)2 ; wherein R1, R2, R3, and R4 are as defined in the specification.
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- Study of structural parameters related to anthelminthic activity of thiazole derivatives
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Thiazole derivatives were synthesized and their anthelminthic activity was tested against a nematode and cestode. The effect of electronic parameters, lipophilicity and biotransformation on activity is discussed.
- Walchshofer,Minjat,Tinland,et al.
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- Sodium Borohydride Reduction of Adducts of Primary Amines with Aldehydes and p-Thiocresol. The Alkylation of Heterocyclic and Aromatic Amino-compounds
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p-Nitroaniline, 2-aminopyridine (1a), 4-aminopyridine (2a), 2-amino-4-methylpyrimidine (8a), 2-aminothiazole (10a), and 2-aminobenzimidazole (12a) react with aqueous formaldehyde and p-thiocresol in ethanol or methanol solution to give N-(p-tolylthiomethyl) derivatives , usually in high yields.When the latter compounds are heated, under reflux, with an excess of sodium borohydride in ethanol or 1,2-dimethoxyethane solution, the corresponding methylamino-compounds are obtained.By a similar two-step prosedure in which aqueous formaldehyde is replaced, as appropriate, by anhydrous acetaldehyde, propionaldehyde, or benzaldehyde, p-nitroaniline is converted into N-ethyl-p-nitroaniline, p-chloroaniline is converted into p-chloro-N-(n-propyl)aniline, (1a) is converted into the corresponding ethylamino- and benzylamino-compounds (1c) and (1d), respectively, and (10a) and (12a) are converted into their 2-N-(n-propyl) derivatives (10c) and (12c), respectively.
- Kemal, Oeznur,Reese, Colin B.
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p. 1569 - 1573
(2007/10/02)
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