10140-87-1

Basic information

• Product Name: 1,2-Dichloroethyl acetate
• Synonyms: Ethanol,1,2-dichloro-, acetate (6CI,7CI,8CI,9CI); 1,2-Dichloroethanol acetate;1,2-Dichloroethyl acetate
• CAS NO: 10140-87-1
• Molecular Formula: C₄H₆Cl₂O₂
• Molecular Weight: 156.99524
• EINECS: 233-398-1
• Mol File: 10140-87-1.mol

Chemical Properties

• Boiling Point: 176.8 °C at 760 mmHg
• Flash Point: 72.4 °C
• Appearance: VISCOUS CLEAR LIQUID.
• Density: 1.295 g/cm3
• Vapor Pressure: 1.07mmHg at 25°C
• Refractive Index: 1.441
• CAS DataBase Reference: 1,2-Dichloroethyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Dichloroethyl acetate(10140-87-1)
• EPA Substance Registry System: 1,2-Dichloroethyl acetate(10140-87-1)

Safety Data

• Hazardous Substances Data: 10140-87-1(Hazardous Substances Data)

Usage

Uses

Used in Chemical Production:
1,2-Dichloroethyl acetate is used as an intermediate in the production of various chemicals, primarily for the synthesis of pesticides and pharmaceuticals. Its chemical properties make it a valuable component in the creation of these products.
Used in Solvent Applications:
In the manufacturing industry, 1,2-Dichloroethyl acetate is utilized as a solvent in a range of applications. It is particularly useful in paint and ink formulations, where its solvent properties contribute to the desired consistency and performance of these products.
Used in Paint and Ink Industry:
1,2-Dichloroethyl acetate is used as a solvent in paint and ink formulations for its ability to dissolve and carry the pigments and dyes, ensuring a smooth application and even distribution of color.
Safety Considerations:
Due to its flammable nature and potential to release toxic fumes when heated, 1,2-Dichloroethyl acetate should be handled with caution. It is essential to store it in a cool, well-ventilated area to minimize the risk of fire or exposure to harmful vapors. Additionally, exposure to this chemical can cause irritation to the skin, eyes, and respiratory system, necessitating the use of appropriate protective measures when working with it.

InChI:InChI=1/C4H6Cl2O2/c1-3(7)8-4(6)2-5/h4H,2H2,1H3

Upstream product

• 107-20-0 2-chloroethanal 
• 75-36-5 acetyl chloride 
• 108-05-4 vinyl acetate 

Downstream Products

• 621-62-5 chloroacetaldehyde diethyl acetal 
• 99844-05-0 4-methoxy-benzaldehyde-thiazol-2-ylhydrazone 
• 63656-05-3 Benzaldehyde 2-thiazolylhydrazone 
• 100517-73-5 acetic acid-[4-(thiazol-2-ylhydrazono-methyl)-anilide] 
• 96-50-4 2-thiazolylamine 
• 6142-06-9 2-methylaminothiazole 
• 33142-18-6 2-phenylaminothiazole 
• 19765-35-6 2-phenylamino-1,3-selenazole 
• 55484-03-2 2-(2'-furyl)pyridine 
• 127-76-4 4'-(thiazol-2-ylsulfamoyl)acetanilide 
• 107-20-0 2-chloroethanal 
• 75-36-5 acetyl chloride 

Relevant articles and documents

A Continuous Flow Sulfuryl Chloride-Based Reaction - Synthesis of a Key Intermediate in a New Route toward Emtricitabine and Lamivudine

We demonstrate a continuous two-step sequence in which sulfenyl chloride is formed, trapped by vinyl acetate, and chlorinated further via a Pummerer rearrangement. These reactions produce a key intermediate in our new approach to the oxathiolane core used to prepare the antiretroviral medicines emtricitabine and lamivudine. During batch scale-up to tens of grams, we found that the sequence featured a strong exotherm and evolution of hydrogen chloride and sulfur dioxide. Keeping gaseous byproducts in solution and controlling the temperature led to better outcomes. These reactions are ideal candidates for implementation in a continuous mesoscale system for the sake of superior control. In addition, we found that fast reagent additions at controlled temperatures decreased byproduct formation. Herein we discuss the flow implementation and the final reactor design that led to a system with a 141 g/h throughput.

CHLOROPHOSPHORYLATION OF ALKENES

An investigation of the chlorophosphorylation reaction of alkenes has established that the chemical direction of the reaction (formation of P-C and P-O-C bonds and chlorination) is controlled predominantly by the polar properties of the radical adduct arising in the initial step from the attack by the chlorine atom on the double bond.The steric influence of the substituents on the radical adduct plays a secondary role.Alkenes with donor substituents, forming radical adducts with nucleophilic character, are more inclined to form a P-C bond.Alkenes with acceptor substituents, forming electrophilic radical adducts, do not react with the electrophilic phosphorus trichloride, leading to formation of compounds with a P-O-C bond or to fragmentation and recombination.

Kinetics of Chromic Acid Oxidation of Aliphatic Acetals in Aqueous Acetic Acid Medium

The oxidation of aliphatic acetals (prepared from aliphatic aldehydes, aliphatic alcohols, halogen substituted alcohols and aromatic alcohols) by chromic acid in aqueous acetic acid medium is first order each in and and yields the corresponding ester as the main product.Substituent effect, activation parameters and salt effects suggest that the elimination of a proton from the complex species involving the acetal and chromium is the rate-determining step.The activation enthalpies and entropies of the reactions are linearly related.

Preparation of 4,4-dioxy-substituted stilbenes

Dehydrohalogenation-rearrangement of 1,1-bis(4-oxy-substituted aryl)-2-haloethanes to yield 4,4'-dioxysubstituted stilbenes is effected by heating an acidic reaction medium comprising the 1,1-bis(4-oxy-substituted aryl)-2-haloethane dissolved in a solution of an aliphatic carboxylic acid and a carboxylic acid salt. The process is particularly directed to the preparation of 4,4'-dihydroxystilbene from 1,1-bis(4-hydroxyphenyl)-2-chloroethane.