6142-06-9

Basic information

• Product Name: N-Methyl-2-thiazolamine
• Synonyms: N-Methyl-2-thiazolamine;N-Methylthiazol-2-aMine;Methyl-thiazol-2-yl-aMine
• CAS NO: 6142-06-9
• Molecular Formula: C₄H₆N₂S
• Molecular Weight: 114.16884
• Mol File: 6142-06-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 174.508 °C at 760 mmHg
• Flash Point: 59.341 °C
• Appearance: /
• Density: 1.246 g/cm³
• Vapor Pressure: 1.202mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 5.38±0.10(Predicted)
• CAS DataBase Reference: N-Methyl-2-thiazolamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-2-thiazolamine(6142-06-9)
• EPA Substance Registry System: N-Methyl-2-thiazolamine(6142-06-9)

Safety Data

• Hazardous Substances Data: 6142-06-9(Hazardous Substances Data)

Usage

General Description

N-Methyl-2-thiazolamine is a chemical compound with the molecular formula C4H5NS. It is a member of the thiazole family, which is characterized by a five-membered ring containing both sulfur and nitrogen atoms. N-Methyl-2-thiazolamine is a colorless to pale yellow liquid with a pungent odor. It is commonly used as an intermediate in the synthesis of pharmaceuticals, pesticides, and other organic compounds. It can also be used as a reagent in chemical reactions, particularly those involving the introduction of the thiazole moiety into a molecule. N-Methyl-2-thiazolamine should be handled with care due to its potential for skin and eye irritation, as well as its flammability.

InChI:InChI=1/C4H6N2S/c1-5-4-6-2-3-7-4/h2-3H,1H3,(H,5,6)

Upstream product

• 10140-87-1 1,2-dichloroethyl acetate 
• 598-52-7 1-(methyl)-thiourea 
• 623-46-1 1,2-dichloro-2-ethoxyethane 
• 7732-18-5 water 
• 25602-39-5 N-(thiazol-2-yl)formamide 
• 3034-53-5 2-bromo-1,3-thiazole 
• 74-89-5 methylamine 
• 78508-29-9 2-(p-tolylthiomethyl)aminothiazole 
• 598-52-7 N-methylisothiourea 
• 43696-08-8 chloroacetaldehyde 

Downstream Products

• 73384-51-7 anhydro-7-Hydroxy-8-methyl-5-oxo-6-phenyl-2H-thiazolo<3,2-a>pyrimidinium hydroxide 
• 102269-22-7 1-Methyl-3-(4-nitro-phenyl)-1-thiazol-2-yl-urea 
• 118215-02-4 2-(N-methylbenzamido)thiazole 
• 102269-20-5 3-(3,4-Dichloro-phenyl)-1-methyl-1-thiazol-2-yl-urea 
• 1208552-53-7 C₁₅H₁₇ClN₂OS 
• 1392467-10-5 methyl 4-[methyl(thiazol-2-yl)sulfamoyl]benzoate 
• 1228593-74-5 2,2,2-trifluoro-1-[2-(methylamino)-1,3-thiazol-5-yl]-1-(5-phenyl-1,3-oxazol-2-yl)ethanol 
• 66507-95-7 4-acetylamino-N-methyl-N-thiazol-2-yl-benzenesulfonamide 
• 858500-74-0 4-nitro-benzenesulfonic acid-(methyl-thiazol-2-yl-amide) 

Relevant articles and documents

SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS

The present invention relates to substituted thiazoles, to methods for the production thereof, to medicaments containing these compounds and to the use thereof for producing medicaments.

N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection

A method for treating HIV which comprises a compound of the formula STR1 wherein A is STR2 and Zi is O, Se, NRa or C(Ra)2, and Zii is --O or (=O)2 ; wherein R1, R2, R3, and R4 are as defined in the specification.

Sodium Borohydride Reduction of Adducts of Primary Amines with Aldehydes and p-Thiocresol. The Alkylation of Heterocyclic and Aromatic Amino-compounds

p-Nitroaniline, 2-aminopyridine (1a), 4-aminopyridine (2a), 2-amino-4-methylpyrimidine (8a), 2-aminothiazole (10a), and 2-aminobenzimidazole (12a) react with aqueous formaldehyde and p-thiocresol in ethanol or methanol solution to give N-(p-tolylthiomethyl) derivatives , usually in high yields.When the latter compounds are heated, under reflux, with an excess of sodium borohydride in ethanol or 1,2-dimethoxyethane solution, the corresponding methylamino-compounds are obtained.By a similar two-step prosedure in which aqueous formaldehyde is replaced, as appropriate, by anhydrous acetaldehyde, propionaldehyde, or benzaldehyde, p-nitroaniline is converted into N-ethyl-p-nitroaniline, p-chloroaniline is converted into p-chloro-N-(n-propyl)aniline, (1a) is converted into the corresponding ethylamino- and benzylamino-compounds (1c) and (1d), respectively, and (10a) and (12a) are converted into their 2-N-(n-propyl) derivatives (10c) and (12c), respectively.