6142-06-9

Usage

Uses

Used in Pharmaceutical Industry:
N-Methyl-2-thiazolamine is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute the thiazole ring structure, which is a common structural motif in various bioactive compounds.
Used in Pesticide Industry:
In the pesticide industry, N-Methyl-2-thiazolamine is utilized as an intermediate to produce active ingredients that possess pesticidal properties, leveraging the thiazole ring for its potential to enhance the effectiveness of these chemicals.
Used in Organic Synthesis:
N-Methyl-2-thiazolamine is used as a reagent in organic synthesis for the introduction of the thiazole moiety into target molecules, which can be crucial for achieving desired chemical and biological properties in the final product.
Used in Chemical Reactions:
As a reagent in chemical reactions, N-Methyl-2-thiazolamine is employed to facilitate the formation of thiazole-containing compounds, which can be important for the development of new materials and substances with specific applications in various fields.

InChI:InChI=1/C4H6N2S/c1-5-4-6-2-3-7-4/h2-3H,1H3,(H,5,6)

Upstream product

• 10140-87-1 1,2-dichloroethyl acetate 
• 598-52-7 1-(methyl)-thiourea 
• 623-46-1 1,2-dichloro-2-ethoxyethane 
• 598-52-7 N-methylisothiourea 
• 43696-08-8 chloroacetaldehyde 
• 78508-29-9 2-(p-tolylthiomethyl)aminothiazole 
• 7732-18-5 water 
• 25602-39-5 N-(thiazol-2-yl)formamide 
• 3034-53-5 2-bromo-1,3-thiazole 
• 74-89-5 methylamine 

Downstream Products

• 858500-74-0 4-nitro-benzenesulfonic acid-(methyl-thiazol-2-yl-amide) 
• 66507-95-7 4-acetylamino-N-methyl-N-thiazol-2-yl-benzenesulfonamide 
• 73384-51-7 anhydro-7-Hydroxy-8-methyl-5-oxo-6-phenyl-2H-thiazolo<3,2-a>pyrimidinium hydroxide 
• 102269-22-7 1-Methyl-3-(4-nitro-phenyl)-1-thiazol-2-yl-urea 
• 118215-02-4 2-(N-methylbenzamido)thiazole 
• 102269-20-5 3-(3,4-Dichloro-phenyl)-1-methyl-1-thiazol-2-yl-urea 
• 1228593-74-5 2,2,2-trifluoro-1-[2-(methylamino)-1,3-thiazol-5-yl]-1-(5-phenyl-1,3-oxazol-2-yl)ethanol 
• 1392467-10-5 methyl 4-[methyl(thiazol-2-yl)sulfamoyl]benzoate 
• 1208552-53-7 C₁₅H₁₇ClN₂OS 

Relevant academic research and scientific papers

SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS

The present invention relates to substituted thiazoles, to methods for the production thereof, to medicaments containing these compounds and to the use thereof for producing medicaments.

Synthesis and rearrangement of N-methyl-N-(2-thiazolyl)-nitramine

Methylation of N-(2-thiazolyl)-nitramine in alkaline solution gives 1,2-dihydro-3-methyl-2-nitriminothiazole which rearranges in concentrated sulphuric acid yielding small amount of 2-(N-methylamino)-5-nitrothiazole, identical with the product of rearrangement of N-methyl-N-(2-thiazolyl)-nitramine. The latter compound was obtained by the action of sodium hydride on 2-(N-methylamino)-thiazole followed by the nitration with n-butyl nitrate.

N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection

A method for treating HIV which comprises a compound of the formula STR1 wherein A is STR2 and Zi is O, Se, NRa or C(Ra)2, and Zii is --O or (=O)2 ; wherein R1, R2, R3, and R4 are as defined in the specification.

Study of structural parameters related to anthelminthic activity of thiazole derivatives

Thiazole derivatives were synthesized and their anthelminthic activity was tested against a nematode and cestode. The effect of electronic parameters, lipophilicity and biotransformation on activity is discussed.

Sodium Borohydride Reduction of Adducts of Primary Amines with Aldehydes and p-Thiocresol. The Alkylation of Heterocyclic and Aromatic Amino-compounds

p-Nitroaniline, 2-aminopyridine (1a), 4-aminopyridine (2a), 2-amino-4-methylpyrimidine (8a), 2-aminothiazole (10a), and 2-aminobenzimidazole (12a) react with aqueous formaldehyde and p-thiocresol in ethanol or methanol solution to give N-(p-tolylthiomethyl) derivatives , usually in high yields.When the latter compounds are heated, under reflux, with an excess of sodium borohydride in ethanol or 1,2-dimethoxyethane solution, the corresponding methylamino-compounds are obtained.By a similar two-step prosedure in which aqueous formaldehyde is replaced, as appropriate, by anhydrous acetaldehyde, propionaldehyde, or benzaldehyde, p-nitroaniline is converted into N-ethyl-p-nitroaniline, p-chloroaniline is converted into p-chloro-N-(n-propyl)aniline, (1a) is converted into the corresponding ethylamino- and benzylamino-compounds (1c) and (1d), respectively, and (10a) and (12a) are converted into their 2-N-(n-propyl) derivatives (10c) and (12c), respectively.