Synthesis and immunosuppressant activity of pyrazole carboxamides
A series of novel pyrazole carboxamides sis disclosed that demonstrate strong immunosuppressant activity in rodent and human mixed leukocyte response (MLR) assays (IC50 1 μM). The synthesis, biological activity, mode of action, and pharmacokinetic properties of this new lead series are discussed.
Wang, Alan X.,Xie, Qinghua,Lane, Ben,Mollison, Karl W.,Hsieh, Gin C.,Marsh, Kennan,Sheets, Michael P.,Luly, Jay R.,Coghlan, Michael J.
p. 2787 - 2792
(2007/10/03)
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