61888-37-7

Basic information

• Product Name: 5-(4-METHYLPHENYL)CYCLOHEXANE-1,3-DIONE
• Synonyms: ASISCHEM C66299;5-(4-METHYLPHENYL)CYCLOHEXANE-1,3-DIONE;5-(4-Methylphenyl)-1,3-Cyclohexanedione;1,3-Cyclohexanedione, 5-(4-Methylphenyl)-;5-(p-Tolyl)cyclohexane-1,3-dione;5-(4-methylphenyl)cyclohexane-1,3-quinone
• CAS NO: 61888-37-7
• Molecular Formula: C₁₃H₁₄O₂
• Molecular Weight: 202.25
• Mol File: 61888-37-7.mol

Chemical Properties

• Melting Point: 176-179°C
• Boiling Point: 372.5°C at 760 mmHg
• Flash Point: 139.7°C
• Appearance: /
• Density: 1.124g/cm³
• Vapor Pressure: 9.57E-06mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: 5-(4-METHYLPHENYL)CYCLOHEXANE-1,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-METHYLPHENYL)CYCLOHEXANE-1,3-DIONE(61888-37-7)
• EPA Substance Registry System: 5-(4-METHYLPHENYL)CYCLOHEXANE-1,3-DIONE(61888-37-7)

Safety Data

• Hazardous Substances Data: 61888-37-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-METHYLPHENYL)CYCLOHEXANE-1,3-DIONE is used as an intermediate in the synthesis of various pharmaceuticals for its potential anti-inflammatory and analgesic properties. It is valued for its ability to contribute to the development of medications that can alleviate pain and reduce inflammation.
Used in Organic Chemistry Research:
In the field of organic chemistry, 5-(4-METHYLPHENYL)CYCLOHEXANE-1,3-DIONE is used as a key building block for the synthesis of complex organic compounds. Its unique structure allows for various chemical reactions, making it a valuable tool in the creation of new molecules with potential applications in different industries.
Used in Disease Treatment Research:
5-(4-METHYLPHENYL)CYCLOHEXANE-1,3-DIONE has been implicated in the treatment of various diseases due to its potential therapeutic properties. It is studied for its role in developing treatments that could address a range of health conditions, highlighting its importance in medical research.
While the specific applications and industries may vary, the common thread in the uses of 5-(4-METHYLPHENYL)CYCLOHEXANE-1,3-DIONE is its role as a versatile chemical intermediate with potential applications in pharmaceutical development, organic synthesis, and disease treatment research.

InChI:InChI=1/C13H14O2/c1-9-2-4-10(5-3-9)11-6-12(14)8-13(15)7-11/h2-5,11H,6-8H2,1H3

Upstream product

• 4023-84-1 4-(p-tolyl)-3-buten-2-one 
• 105-53-3 diethyl malonate 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 1204872-73-0 3-(3-oxo-5-p-tolylcyclohex-1-enylamino)thiophene-2-carbonitrile 
• 1372610-97-3 1-hydroxy-3-p-tolyl-6H-benzo[c]chromen-6-one 
• 1372611-02-3 1-hydroxy-8-methoxy-3-p-tolyl-6H-benzo[c]chromen-6-one 
• 1030419-81-8 2-dimethylaminomethylene-5-p-tolyl-cyclohexane-1,3-dione 
• 299934-78-4 2-(((2-(piperazin-1-yl)ethyl)amino)methylene)-5-(p-tolyl)cyclohexane-1,3-dione 
• 351163-54-7 2-(4-(2-(((2,6-dioxo-4-(p-tolyl) cyclohexylidene)methyl)amino)ethyl)piperazin-1-yl)-N-(p-tolyl)acetamide 
• 203645-98-1 3,5-dihydroxy-4′-methyl-1,1′-biphenyl 
• 1609374-99-3 2-(1-((2-methoxyphenyl)amino)ethylidene)-5-(p-tolyl)cyclohexane-1,3-dione 
• 1083067-15-5 2-acetyl-5-(p-tolyl)cyclohexane-1,3-dione 
• 1407229-50-8 C₂₄H₂₀O₂ 
• 1407229-49-5 C₂₀H₁₈O₂ 
• 1252047-98-5 2-(3-oxo-5-p-tolyl-cyclohex-1-enylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile 
• 1001091-83-3 2-(3-oxo-5-p-tolylcyclohex-1-enylamino)thiophene-3-carbonitrile 

Relevant articles and documents

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Construction of Multiple-Substituted Chiral Cyclohexanes through Hydrogenative Desymmetrization of 2,2,5-Trisubstituted 1,3-Cyclohexanediones

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Dehydrogenative Formation of Resorcinol Derivatives Using Pd/C-Ethylene Catalytic System

The conversion of substituted 1,3-cyclohexanediones to the alkyl ethers of resorcinol using a Pd/C-ethylene system is reported. In these reactions, ethylene works as a hydrogen acceptor. The efficient synthesis of resveratrol was achieved using this protocol as a key step. In addition, the direct formation of substituted resorcinols was carried out by adding K2CO3 into the reaction media.

INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE

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Tandem reactions leading to benzo[c]chromen-6-ones and 3-substituted isocoumarins

A simple and convenient protocol for the synthesis of benzo[c]chromen-6- ones and 3-substituted isocoumarins through a CuI-catalyzed tandem reaction of 2-bromobenzoates withcyclohexane-1,3-diones or acyclic 1,3-diones is developed. This strategy can also be extended to the one-pot synthesis of isoquinolin-1(2H)-one and 3,4-dihydrophenanthridine-1,6(2H,5H)-dione. A simple and convenient protocol for the synthesis of benzo[c]chromen-6-ones and 3-substituted isocoumarins through a CuI-catalyzed tandem reaction of 2-bromobenzoates with cyclohexane-1,3-dione or acyclic 1,3-dione has been developed. This strategy can also be extended to the one-pot synthesis of isoquionlin-1(2H)-one and 3,4-dihydrophenanthridine-1,6-(2H,5H)-dione. Copyright

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