- Production process of adrenal glands
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The invention discloses a production technology for carbazochrome. The production technology comprises the following steps: 1) synthesizing chloracetyl catechol; 2) synthesizing corticosterone hydrochloride; 3) synthesizing adrenaline; and 4) synthesizing the carbazochrome. The production technology for the carbazochrome, disclosed by the invention, has the advantages of simple preparation method,few steps and easiness for operation and control; and an obtained product has good color and luster, good quality, high purity and high yield, can be directly used for production and utilization andhas very good practicability.
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- Preparation method of adrenalone hydrochloride
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The invention relates to a preparation method of adrenalone hydrochloride. In a process of preparing the adrenalone hydrochloride from chloracetyl catechol and methylamine, reaction is controlled to be carried out in an alcohol solution and tetrabutylammonium bromide or tetrabutylammonium iodide is selected as a phase transfer catalyst. According to the method provided by the invention, the reaction is controlled to be carried out in the alcohol solution and sufficient proceeding of the reaction is promoted; meanwhile, the tetrabutylammonium bromide or the tetrabutylammonium iodide is added to be used as the phase transfer catalyst, so that the reaction is accelerated, the reaction time is shortened and the accumulation of impurities is reduced. The adrenalone hydrochloride with high quality can be prepared at a single time without the need of refining, and a high-quality intermediate is provided for preparation of L-adrenaline.
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Paragraph 0014; 0034; 0035; 0039; 0040; 0044; 0045
(2017/07/21)
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- PROCESS FOR THE PREPARATION OF OPTICALLY ENRICHED ADRENALINE
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A process for the production of (-)-adrenaline and (-)-adrenaline-L-tartrate is provided. The process provides for a new, efficient and commercially feasible process for the optical resolution of racemic adrenaline. In one aspect, a one pot process for the synthesis of (-)-adrenaline is provided. The process provides a simple and less expensive 5 process that can be used to prepare commercial scale batches of (-)-adrenaline and (-)-adrenaline-L-tartrate of API quality. The process avoids the use of expensive and unpredictable chiral catalysts.
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Paragraph 0046-0056
(2016/06/01)
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