54-06-8Relevant articles and documents
Activation of H2O2 and superoxide production using a novel cobalt complex based on a polyampholyte
Lombardo Lupano, Lucía V.,Lázaro Martínez, Juan Manuel,Piehl, Lidia Leonor,Rubin De Celis, Emilio,Campo Dall'Orto, Viviana
, p. 342 - 354 (2013)
A new catalyst based on Co(II) and a hydrogel with property of polyampholyte was characterized by equilibrium studies of Co(II) uptake, solid-state NMR and energy dispersive X-ray analysis. The matrix derived from methacrylic acid and 2-methylimidazole is easily synthesized in one-spot strategy, and combines coordination properties with chemical resistance. The catalytic activity of this material on H2O2 activation was studied by electron spin resonance, which confirmed the release of superoxide radical. A possible mechanism of interaction involves the simultaneous production of dioxygen, protons and water. The catalytic performance was assessed in the activation of H2O2 for the oxidation of two representative organic compounds of environmental concern. About 70% of methyl orange, a model azo dye, was removed from distilled water in 2 h by oxidation with H2O2 60 mM and by adsorption on the catalyst. The amount of adsorbed dye was minimized in the presence of 0.1 M Na2SO4. The kinetics of the processes followed a pseudo-first-order empirical model, and the catalyst was recovered and re-used. Epinephrine was chosen as a pharmaceutical model susceptible to superoxide attack. About 80% of conversion to adrenochrome was reached in less than 6 min, following a pseudo-first-order kinetic model.
Kinetic studies on the manganese(II) complex catalyzed oxidation of epinephrine
Szigyártó, I.Cs.,Szabó,Simándi
, p. 66 - 71 (2013)
The manganese complex [Mn2(HL)2](BPh 4)2 was found to be a selective catalyst for the oxidation of epinephrine (a catecholamine derivative) to adrenochrome at room temperature in sodium carbonate-bicarbonate buffer. The epinephrine auto-oxidation rate significantly increases upon the addition of manganese complex. The kinetics of reaction was studied by spectrophotometric method, monitoring the increase in concentration of adrenochrome product. According to the proposed mechanism, O2 binding to the manganese complex is followed by the formation of a ternary catalyst-dioxygen-substrate complex as active intermediate, which decomposes in a rate-determining step, generating the adrenochrome.
The Oxovanadyl(IV) catalysed Oxidation of Adrenaline by Molecular Oxygen
Jameson, Reginald F.,Kiss, Tamas
, p. 1833 - 1838 (1986)
The oxidation of adrenaline (H2LH+) by molecular oxygen in the presence of catalytic amounts of VO2+ ions has been followed using a Clark-type oxygen electrode.The empirical rate law -d/dt = kobs. + p was obtained in which p is a small constant (only observable at low pH) and kobs. is given by the relationship (i), where T and T are total initial concentrations of (i) VO2+ and adrenaline respectively.It is demonstrated that this behaviour is consistent with the involvement of both VO2+ and V2+ species and furthermore that it also calls for the presence of a tris(adrenaline) species, V(LH)3+.A kinetically determined equilibrium constant for reaction (ii) is VO(LH)2 + H2LH+ V(LH)3+ + H2O (ii) reported.The necessary proton- and metal-ligand equilibrium constants were obtained by pH- and 1H n.m.r.-titration techniques.All solutions were made up to a constant ionic strength (I = 0.100 mol dm-3) with KNO3 at 25.00 +/- 0.02 deg C.
Production process of adrenal glands
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, (2021/11/15)
The invention discloses a production technology for carbazochrome. The production technology comprises the following steps: 1) synthesizing chloracetyl catechol; 2) synthesizing corticosterone hydrochloride; 3) synthesizing adrenaline; and 4) synthesizing the carbazochrome. The production technology for the carbazochrome, disclosed by the invention, has the advantages of simple preparation method,few steps and easiness for operation and control; and an obtained product has good color and luster, good quality, high purity and high yield, can be directly used for production and utilization andhas very good practicability.
