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(1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-ACETIC ACID ETHYL ESTER, a chemical compound with the molecular formula C12H18O4, belongs to the class of organic compounds known as carboxylic acid esters. These esters are formed from a carboxylic acid and an alcohol, and the unique presence of the dioxa-spirodecane moiety in its structure distinguishes this compound. It is recognized for its distinctive properties that make it suitable for various applications in the consumer products industry.

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  • 62141-26-8 Structure
  • Basic information

    1. Product Name: (1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-ACETIC ACID ETHYL ESTER
    2. Synonyms: (1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-ACETIC ACID ETHYL ESTER;ethyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate;1,4-Dioxaspiro[4.5]decane-8-acetic acid, ethyl ester;Ethyl 1,4-dioxaspiro[4.5]decane-8-acetate;(1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-ACETIC ACID ETHYL ESTER-25;Ethyl 2-(1,4-dioxaspiro[4.5]dec-8-yl)acetate
    3. CAS NO:62141-26-8
    4. Molecular Formula: C12H20O4
    5. Molecular Weight: 228.28
    6. EINECS: N/A
    7. Product Categories: Miscellaneous
    8. Mol File: 62141-26-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 308.4±17.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.10±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
    10. NIST Chemistry Reference: (1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-ACETIC ACID ETHYL ESTER(62141-26-8)
    11. EPA Substance Registry System: (1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-ACETIC ACID ETHYL ESTER(62141-26-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 62141-26-8(Hazardous Substances Data)

62141-26-8 Usage

Uses

Used in Flavoring and Fragrance Industry:
(1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-ACETIC ACID ETHYL ESTER is used as a flavoring agent and fragrance ingredient for its unique aromatic properties, adding to the sensory experience of various consumer products.
Used in Perfume Production:
In the perfume industry, (1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-ACETIC ACID ETHYL ESTER is used as a component in creating complex and appealing scents, contributing to the overall composition of perfumes.
Used in Soap Making:
(1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-ACETIC ACID ETHYL ESTER is utilized in the production of soaps, where it imparts pleasant odors and enhances the sensory appeal of the product.
Used in Cleaning Products:
(1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-ACETIC ACID ETHYL ESTER is also used in the formulation of cleaning products, where it serves to provide a fresh scent and improve the overall user experience.
Safety Precautions:
It is important to handle (1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-ACETIC ACID ETHYL ESTER with care, as it may cause irritation to the skin, eyes, and respiratory system upon exposure. Proper safety measures should be taken to minimize potential health risks during its use in various applications.

Check Digit Verification of cas no

The CAS Registry Mumber 62141-26-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,1,4 and 1 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 62141-26:
(7*6)+(6*2)+(5*1)+(4*4)+(3*1)+(2*2)+(1*6)=88
88 % 10 = 8
So 62141-26-8 is a valid CAS Registry Number.

62141-26-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate

1.2 Other means of identification

Product number -
Other names 8-ethoxycarbonylmethyl-1,4-dioxaspiro[4.5]decane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:62141-26-8 SDS

62141-26-8Relevant articles and documents

Harnessing Additional Capability from in Water Reaction Conditions: Aldol versus Knoevenagel Chemoselectivity

Ali El Damrany Hussein, Hussein,Debnath, Samarpita,Goswami, Falguni,Hussain, Ishtiaq,Karn, Alka,Nakka, Srinuvasu,Nugent, Thomas C.

, p. 3539 - 3545 (2021/06/12)

Aldol reaction chemoselectivity, racemic or enantioselective, has not been previously demonstrated in the presence of Knoevenagel active functional groups. Here, we show that unhindered β-diketones remain unreacted while a ketone moiety undergoes a highly

MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE

-

, (2019/06/23)

Provided are IDO1 inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases.

INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE

-

, (2018/03/25)

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3 -dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A BICYCLO MOIETY

-

, (2017/02/28)

The disclosure provides compounds having formula (I), wherein the substituents are as defined herein. The compounds are useful for modulating the dopamine D3 receptor and for treating conditions associated therewith, such as addictions, drug dependency, and psychiatric conditions.

INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE

-

, (2017/12/13)

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

IMMUNOREGULATORY AGENTS

-

, (2016/06/01)

Compounds that modulate the oxidoreductase enzyme indoleamine 2,3- dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

IMMUNOREGULATORY AGENTS

-

, (2016/06/01)

Compounds that modulate the oxidoreductase enzyme indoleamine 2,3- dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

IMMUNOREGULATORY AGENTS

-

, (2016/06/01)

Compounds that modulate the oxidoreductase enzyme indoleamine 2,3- dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases,

Hydroxypurine compound and use thereof

-

, (2016/10/08)

The invention discloses a hydroxypurine compound and a use of the hydroxypurine compound as a PDE2 or TNFa inhibitor and concretely discloses a compound shown in the formula (I) and its tautomer or pharmaceutically acceptable salt.

Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease

Rabal, Obdulia,Sánchez-Arias, Juan A.,Cuadrado-Tejedor, Mar,De Miguel, Irene,Pérez-González, Marta,García-Barroso, Carolina,Ugarte, Ana,Estella-Hermoso De Mendoza, Ander,Sáez, Elena,Espelosin, Maria,Ursua, Susana,Haizhong, Tan,Wei, Wu,Musheng, Xu,Garcia-Osta, Ana,Oyarzabal, Julen

, p. 8967 - 9004 (2016/10/22)

Simultaneous inhibition of phosphodiesterase 5 (PDE5) and histone deacetylases (HDAC) has recently been validated as a potentially novel therapeutic approach for Alzheimer's disease (AD). To further extend this concept, we designed and synthesized the first chemical series of dual acting PDE5 and HDAC inhibitors, and we validated this systems therapeutics approach. Following the implementation of structure- and knowledge-based approaches, initial hits were designed and were shown to validate our hypothesis of dual in vitro inhibition. Then, an optimization strategy was pursued to obtain a proper tool compound for in vivo testing in AD models. Initial hits were translated into molecules with adequate cellular functional responses (histone acetylation and cAMP/cGMP response element-binding (CREB) phosphorylation in the nanomolar range), an acceptable therapeutic window (>1 log unit), and the ability to cross the blood-brain barrier, leading to the identification of 7 as a candidate for in vivo proof-of-concept testing (Cuadrado-Tejedor, M.; Garcia-Barroso, C.; Sánchez-Arias, J. A.; Rabal, O.; Mederos, S.; Ugarte, A.; Franco, R.; Segura, V.; Perea, G.; Oyarzabal, J.; Garcia-Osta, A. Neuropsychopharmacology 2016, in press, doi: 10.1038/npp.2016.163).

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