- COMPOSITIONS AND METHODS FOR TARGETING RECEPTORS EXPRESSED IN THE GUT
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The invention relates to novel compounds and pharmaceutical preparations thereof, as well as methods of making and using these compounds. The invention further relates to methods of treating or preventing disease using the novel compounds of the invention
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Page/Page column 39; 40
(2016/02/09)
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- Synthesis and evaluation of indole, pyrazole, chromone and pyrimidine based conjugates for tumor growth inhibitory activities - Development of highly efficacious cytotoxic agents
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Based upon the lead compounds 10 and 11, a number of conjugates were synthesized by the combination of chromone-pyrimidine, chromone-indolinone, chromone-pyrazole, indole-pyrimidine, indole-indolinone and indole-pyrazole moieties. Evaluation of these compounds for tumor growth inhibitory activities over 60 human tumor cell lines provided highly efficacious compounds 15, 41, 43, 66, 69, and 72 with an average GI50 over all the 60 human tumor cell lines as 3.2 μM, 3.1 μM, 1.7 μM, 2.6 μM, 50.1 μM and 2.0 μM, respectively.
- Singh, Palwinder,Kaur, Matinder,Holzer, Wolfgang
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experimental part
p. 4968 - 4982
(2010/11/20)
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- A catalytic antibody programmed for torsional activation of amide bond hydrolysis
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Amidase antibody 312d6, obtained against the sulfonamide hapten 4a that mimics the transition state for hydrolysis of a distorted amide, accelerates the hydrolysis of the corresponding amides 1a-3a by a factor of 103 at pH 8. The mechanisms of
- Aggarwal, Ranjana,Benedetti, Fabio,Berti, Federico,Buchini, Sabrina,Colombatti, Alfonso,Dinon, Francesca,Galasso, Vinicio,Norbedo, Stefano
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p. 3132 - 3142
(2007/10/03)
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