cas 622369-40-8, 4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE | Articles data ｜lookchem

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622369-40-8

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3-Cyanoquinolines, Methods for Preparation and Use as Insulin-like Growth Factor Inhibitors
Imidazole-substituted 4-anilino-3-cyanoquinolines are described, which selectively inhibit IFGR kinase activity and are useful for treating disorders associated with IGFR kinases.
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Page/Page column 13

(2009/10/30)

4-ANILINO-3-QUINOLINECARBONITRILES FOR THE TREATMENT OF CHRONIC MYELOGENOUS LEUKEMIA (CML)
Compounds of the formula (I): wherein: n is an integer from 0-3; X is N, CH; R is alkyl of 1 to 3 carbon atoms; R' is 2,4-diCl, 5-OMe in para, ortho, or meta position; 2,4-diCl in para position; 3,4,5-tri-OMe in para position; 2-Cl, 5-OMe in para position
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Page/Page column 22-23

(2010/02/11)

7-Alkoxy-4-phenylamino-3-quinolinecarbonitriles as Dual Inhibitors of Src and Abl Kinases
We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kina
Boschelli, Diane H.,Wang, Yanong D.,Johnson, Steve,Wu, Biqi,Ye, Fei,Barrios Sosa, Ana Carolina,Golas, Jennifer M.,Boschelli, Frank
p. 1599 - 1601
(2007/10/03)

Process for the preparation of 7-substituted-3 quinolinecarbonitriles
There is provided a process for the preparation of 7-substituted-3-quinolinecarbonitriles and intermediates useful in a process to prepare 7-substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-
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Page/Page column 11

(2010/11/30)

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Chemical Properties

Boiling Point: 394.76°C at 760 mmHg
Flash Point:192.544°C
Density: 1.432g/cm³
Storage Temp.:2-8°C
Vapor Pressure: 0mmHg at 25°C
PKA: -0.82±0.41(Predicted)
PSA: 45.91000
LogP: 2.90758

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