622369-38-4

Basic information

• Product Name: 7-FLUORO-6-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBONITRILE
• Synonyms: 7-FLUORO-6-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBONITRILE;7-FLUORO-1,4-DIHYDRO-6-METHOXY-4-OXO-3-QUINOLINE;7-Fluoro-6-methoxy-4-oxo-1,4-dihydro-3-quinolinecarbonitrile;3-Quinolinecarbonitrile, 7-fluoro-1,4-dihydro-6-Methoxy-4-oxo-;7-fluoro-6-methoxy-4-oxo-1H-quinoline-3-carbonitrile
• CAS NO: 622369-38-4
• Molecular Formula: C₁₁H₇FN₂O₂
• Molecular Weight: 218.1838832
• Mol File: 622369-38-4.mol

Chemical Properties

• Boiling Point: 362.703 °C at 760 mmHg
• Flash Point: 173.157 °C
• Appearance: /
• Density: 1.40
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.599
• PKA: 2.26±0.50(Predicted)
• CAS DataBase Reference: 7-FLUORO-6-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-FLUORO-6-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBONITRILE(622369-38-4)
• EPA Substance Registry System: 7-FLUORO-6-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBONITRILE(622369-38-4)

Safety Data

• Hazardous Substances Data: 622369-38-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
7-Fluoro-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile is used as a research compound for exploring its potential biological activities. The presence of various functional groups in its structure allows for the investigation of its anti-cancer, anti-inflammatory, and antimicrobial properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 7-Fluoro-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile is used as a starting material or a building block for the synthesis of new compounds with improved pharmacological properties. The fluoro and methoxy groups in this compound can be further modified to optimize its biological activity and selectivity.
Used in Drug Design and Development:
7-Fluoro-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile is utilized in drug design and development processes to create novel therapeutic agents with potential applications in various diseases and conditions. Its unique structure and functional groups make it a valuable candidate for the development of new drugs with enhanced efficacy and safety profiles.
Used in Chemical Synthesis:
7-Fluoro-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile serves as an intermediate in the synthesis of other quinoline-based compounds. Its versatile structure allows for further functionalization and modification, enabling the preparation of a wide range of quinoline derivatives with diverse applications in various fields, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C11H7FN2O2/c1-16-10-2-7-9(3-8(10)12)14-5-6(4-13)11(7)15/h2-3,5H,1H3,(H,14,15)

Upstream product

• 366-99-4 3-fluoro-4-methoxyaniline 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 622369-37-3 7-fluoro-6-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxamide 

Downstream Products

• 622369-51-1 6-benzyloxy-4-chloro-7-fluoro-3-quinolinecarbonitrile 
• 622369-40-8 4-chloro-6-methoxy-7-fluoro-quinoline-3-carbonitrile 
• 622368-90-5 4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-3-ylmethoxy)-quinoline-3-carbonitrile 
• 622369-26-0 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidine-2-yl)methoxy]quinoline-3-carbonitrile 
• 681819-23-8 4-[(2,4-dichloro-5-ethoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 622369-54-4 7-fluoro-6-methoxy-4-[(3,4,5-trimethoxyphenyl)amino]-3-quinolinecarbonitrile 
• 622369-46-4 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 622369-76-0 4-[(2,4-dimethyl-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 622369-75-9 4-[(2,4-dichlorophenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 622369-78-2 7-fluoro-6-methoxy-4-[(5-methoxy-2-methylphenyl)amino]-3-quinolinecarbonitrile 
• 622369-79-3 4-[(2,4-dimethylphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 622369-21-5 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-methylpiperidin-4-yl)propoxy]quinoline-3-carbonitrile 
• 622368-88-1 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[2-(1-methylpiperidin-4-yl)ethoxy]-3-quinolinecarbonitrile 
• 380843-75-4 bosutinib 

Relevant articles and documents

3-Cyanoquinolines, Methods for Preparation and Use as Insulin-like Growth Factor Inhibitors

Imidazole-substituted 4-anilino-3-cyanoquinolines are described, which selectively inhibit IFGR kinase activity and are useful for treating disorders associated with IGFR kinases.

4-ANILINO-3-QUINOLINECARBONITRILES FOR THE TREATMENT OF CHRONIC MYELOGENOUS LEUKEMIA (CML)

Compounds of the formula (I): wherein: n is an integer from 0-3; X is N, CH; R is alkyl of 1 to 3 carbon atoms; R' is 2,4-diCl, 5-OMe in para, ortho, or meta position; 2,4-diCl in para position; 3,4,5-tri-OMe in para position; 2-Cl, 5-OMe in para position

7-Alkoxy-4-phenylamino-3-quinolinecarbonitriles as Dual Inhibitors of Src and Abl Kinases

We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kina

Process for the preparation of 7-substituted-3 quinolinecarbonitriles

There is provided a process for the preparation of 7-substituted-3-quinolinecarbonitriles and intermediates useful in a process to prepare 7-substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-