622369-40-8 Usage
Uses
Used in Pharmaceutical Research and Drug Development:
4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE is used as a key intermediate in the synthesis of compounds with potential biological activity. Its unique structure and functional groups contribute to the development of new pharmaceuticals with improved therapeutic effects.
Used in Agrochemicals Production:
In the agrochemical industry, 4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE is used as a building block for the creation of novel agrochemicals. Its properties allow for the development of compounds with enhanced pesticidal or herbicidal activities, contributing to more effective crop protection strategies.
Used in Medicinal Chemistry:
4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE is employed as a starting material in medicinal chemistry for the design and synthesis of new drug candidates. Its presence of chlorine, fluorine, and methoxy groups can be leveraged to fine-tune the pharmacokinetic and pharmacodynamic properties of the resulting compounds, leading to improved drug efficacy and safety profiles.
Used in Chemical Synthesis:
As a versatile organic chemical compound, 4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE is used in various chemical synthesis processes. Its reactivity and functional groups make it suitable for the preparation of a wide range of organic compounds, including dyes, pigments, and other specialty chemicals, for diverse applications across different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 622369-40-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,2,3,6 and 9 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 622369-40:
(8*6)+(7*2)+(6*2)+(5*3)+(4*6)+(3*9)+(2*4)+(1*0)=148
148 % 10 = 8
So 622369-40-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H6ClFN2O/c1-16-10-2-7-9(3-8(10)13)15-5-6(4-14)11(7)12/h2-3,5H,1H3
622369-40-8Relevant academic research and scientific papers
3-Cyanoquinolines, Methods for Preparation and Use as Insulin-like Growth Factor Inhibitors
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Page/Page column 13, (2009/10/30)
Imidazole-substituted 4-anilino-3-cyanoquinolines are described, which selectively inhibit IFGR kinase activity and are useful for treating disorders associated with IGFR kinases.
4-ANILINO-3-QUINOLINECARBONITRILES FOR THE TREATMENT OF CHRONIC MYELOGENOUS LEUKEMIA (CML)
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Page/Page column 22-23, (2010/02/11)
Compounds of the formula (I): wherein: n is an integer from 0-3; X is N, CH; R is alkyl of 1 to 3 carbon atoms; R' is 2,4-diCl, 5-OMe in para, ortho, or meta position; 2,4-diCl in para position; 3,4,5-tri-OMe in para position; 2-Cl, 5-OMe in para position
7-Alkoxy-4-phenylamino-3-quinolinecarbonitriles as Dual Inhibitors of Src and Abl Kinases
Boschelli, Diane H.,Wang, Yanong D.,Johnson, Steve,Wu, Biqi,Ye, Fei,Barrios Sosa, Ana Carolina,Golas, Jennifer M.,Boschelli, Frank
, p. 1599 - 1601 (2007/10/03)
We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kina
Process for the preparation of 7-substituted-3 quinolinecarbonitriles
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Page/Page column 11, (2010/11/30)
There is provided a process for the preparation of 7-substituted-3-quinolinecarbonitriles and intermediates useful in a process to prepare 7-substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-
