622369-40-8

Basic information

• Product Name: 4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE
• Synonyms: 4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE;4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-7-FLUORO-6-METHOXY-3-QUINOLINE;4-CHLORO-7-FLUORO-6-METHOXY-3-QUINOLINE;3-Quinolinecarbonitrile, 4-chloro-7-fluoro-6-methoxy-;4-Chloro-7-fluoro-6-Methoxy-3-quinolinecarbonitrile
• CAS NO: 622369-40-8
• Molecular Formula: C₁₁H₆ClFN₂O
• Molecular Weight: 236.63
• Mol File: 622369-40-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 394.76°C at 760 mmHg
• Flash Point: 192.544°C
• Appearance: /
• Density: 1.432g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: 2-8°C
• PKA: -0.82±0.41(Predicted)
• CAS DataBase Reference: 4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE(622369-40-8)
• EPA Substance Registry System: 4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE(622369-40-8)

Safety Data

• Hazardous Substances Data: 622369-40-8(Hazardous Substances Data)

Usage

General Description

4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE is an organic chemical compound with the molecular formula C11H7ClFNO2. It is a quinoline derivative that contains a carbonitrile group. This chemical is commonly used in pharmaceutical research and drug development, particularly in the synthesis of compounds with potential biological activity. Its unique structure and properties make it a valuable intermediate for the production of various pharmaceuticals and agrochemicals. Additionally, its presence of chlorine, fluorine, and methoxy groups contribute to its potential pharmacological properties and make it an important target for further studies and applications.

InChI:InChI=1/C11H6ClFN2O/c1-16-10-2-7-9(3-8(10)13)15-5-6(4-14)11(7)12/h2-3,5H,1H3

Upstream product

• 1142189-70-5 7-fluoro-4-hydroxy-6-methoxy-quinoline-3-carbonitrile 
• 366-99-4 3-fluoro-4-methoxyaniline 
• 622369-38-4 7-fluoro-6-methoxy-4-oxo-1,4-dihydro-3-quinolinecarbonitrile 

Downstream Products

• 622369-75-9 4-[(2,4-dichlorophenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 1190752-95-4 4-{3-chloro-4-[(1,4,5-trimethyl-1H-imidazol-2-yl)thio]phenyl}amino-7-fluoro-6-methoxyquinoline-3-carbonitrile 
• 1190752-98-7 4-[3-Chloro-4-(4,5-dimethyl-1-propyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-7-fluoro-6-methoxy-quinoline-3-carbonitrile 
• 1190752-96-5 4-[3-chloro-4-(1-ethyl-4,5-dimethyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-7-fluoro-6-methoxy-quinoline-3-carbonitrile 
• 622368-90-5 4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-3-ylmethoxy)-quinoline-3-carbonitrile 
• 622369-26-0 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidine-2-yl)methoxy]quinoline-3-carbonitrile 
• 622369-21-5 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-methylpiperidin-4-yl)propoxy]quinoline-3-carbonitrile 
• 622368-88-1 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[2-(1-methylpiperidin-4-yl)ethoxy]-3-quinolinecarbonitrile 
• 380843-75-4 bosutinib 
• 622369-57-7 4-({3-chloro-4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}amino)-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 681819-23-8 4-[(2,4-dichloro-5-ethoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 622369-78-2 7-fluoro-6-methoxy-4-[(5-methoxy-2-methylphenyl)amino]-3-quinolinecarbonitrile 
• 622369-54-4 7-fluoro-6-methoxy-4-[(3,4,5-trimethoxyphenyl)amino]-3-quinolinecarbonitrile 
• 622369-79-3 4-[(2,4-dimethylphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 

Relevant articles and documents

3-Cyanoquinolines, Methods for Preparation and Use as Insulin-like Growth Factor Inhibitors

Imidazole-substituted 4-anilino-3-cyanoquinolines are described, which selectively inhibit IFGR kinase activity and are useful for treating disorders associated with IGFR kinases.

7-Alkoxy-4-phenylamino-3-quinolinecarbonitriles as Dual Inhibitors of Src and Abl Kinases

We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kina