62351-48-8

Basic information

• Product Name: 3,5-Difluorobiphenyl
• Synonyms: 3,5-Difluoro-1,1'-biphenyl;3,5-Difluorobiphenyl
• CAS NO: 62351-48-8
• Molecular Formula: C₁₂H₈F₂
• Molecular Weight: 190.19
• Mol File: 62351-48-8.mol

Chemical Properties

• Boiling Point: 256°C at 760 mmHg
• Flash Point: 89.5°C
• Appearance: /
• Density: 1.165g/cm³
• Vapor Pressure: 0.0254mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: 3,5-Difluorobiphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Difluorobiphenyl(62351-48-8)
• EPA Substance Registry System: 3,5-Difluorobiphenyl(62351-48-8)

Safety Data

• Hazardous Substances Data: 62351-48-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H8F2/c13-11-6-10(7-12(14)8-11)9-4-2-1-3-5-9/h1-8H

Upstream product

• 372-18-9 1,3-Difluorobenzene 
• 94-36-0 dibenzoyl peroxide 
• 372-38-3 1,3,5-trifluorobenzene 
• 591-50-4 iodobenzene 
• 156545-07-2 3,5-difluorophenylboronic acid 
• 178820-23-0 3,4,5-trifluoro-1-1’-biphenyl 

Relevant articles and documents

Niobium-catalyzed reduction of monofluoroarenes with LiAlH4

It was found that monofluoroarenes were reduced to the corresponding hydrodefluorinated arenes by the treatment of 5 mol% of NbCl5 and LiAlH4. Based on the substituent effect observed, an aromatic nucleophilic substitution mechanism

Palladium chloride/tetraphenylphosphonium bromide intercalated clay: New catalyst for cross-coupling of aryl halides with arylboronic acids

A facile method for the preparation of biaryl compounds is described from readily accessible aryl halides and arylboronic acids using palladium chloride/tetraphenylphosphonium bromide intercalated clay as a new catalyst.

Homolytic Reactions of Polyfluoroaromatic Compounds. Part 16. Competitive Phenylation of Polyfluorobenzenes

Pairs of polyfluorobenzenes were allowed to compete for phenyl radicals generated by thermolysis of benzoyl peroxide at 80 deg C.From the relative yields of biaryl, and the yields of each biaryl formed upon arylation of each arene individually, the relative rates of attack of each site in each arene were deduced.Neither iron(III) benzoate nor trichloroacetic acid uniformly improved yields of biaryl, although in some cases the isomer distribution altered, when decomposition of benzoyl peroxide was carried out in the presence of such additives, to favour products of aryldehydrogenation or of aryldefluorination, respectively.Competition did not usually affect the distribution of attack of a particular arene, except when hexafluorobenzene was used, in which case greater selectivity of attack of the second arene occured.This suggested the formation of a 'stabilised' phenyl radical, and supported an earlier suggestion of species such as >; other evidence also supported the postulate.