178820-23-0

Basic information

• Product Name: 1,1'-Biphenyl, 3,4,5-trifluoro-
• CAS NO: 178820-23-0
• Molecular Formula: C12H7F3
• Molecular Weight: 208.183
• Mol File: 178820-23-0.mol
• Article Data: 13

Chemical Properties

• Melting Point: 56 °C
• Boiling Point: 257.4±35.0 °C(Predicted)
• Density: 1.244±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1,1'-Biphenyl, 3,4,5-trifluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1'-Biphenyl, 3,4,5-trifluoro-(178820-23-0)
• EPA Substance Registry System: 1,1'-Biphenyl, 3,4,5-trifluoro-(178820-23-0)

Safety Data

• Hazardous Substances Data: 178820-23-0(Hazardous Substances Data)

Usage

Structure

1,1'-Biphenyl with three fluorine atoms at the 3, 4, and 5 positions

Explanation

The compound is a derivative of biphenyl, which consists of two phenyl rings connected by a carbon-carbon bond. The three fluorine atoms are attached to the biphenyl molecule at the 3, 4, and 5 positions, altering its reactivity and physical properties.

Explanation

Biphenyl is an aromatic hydrocarbon, and the introduction of fluorine atoms does not change this classification. Aromatic hydrocarbons contain a planar, unsaturated ring of carbon atoms with delocalized electrons.

Explanation

The unique structural features of 1,1'-Biphenyl, 3,4,5-trifluoromake it a valuable building block for various industrial and research applications, including the synthesis of pharmaceuticals, agrochemicals, and the production of liquid crystals and electronic materials.

Explanation

The introduction of fluorine atoms to the biphenyl molecule can lead to changes in the physical properties of the compound, such as melting point, boiling point, solubility, and density.

Explanation

The compound's unique structure and properties make it a useful building block for the development of new materials and chemical compounds in various industrial and research applications.

Explanation

1,1'-Biphenyl, 3,4,5-trifluorois a derivative of biphenyl, which means it is a compound that has been structurally modified from the original biphenyl molecule by the addition of fluorine atoms.

Aromatic Hydrocarbon

Yes

Reactivity

Altered due to fluorine substitution

Applications

Pharmaceutical and agrochemical synthesis, liquid crystals, and electronic materials

Physical Properties

Altered by fluorine substitution

Industrial and Research Applications

Development of new materials and chemical compounds

Derivative of Biphenyl

Yes

Upstream product

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Downstream Products

• 62351-48-8 3,5-difluorobiphenyl 
• 324-74-3 4-fluoro-biphenyl 

Relevant articles and documents

A simple method for preparing imidazolium-based polymer as solid catalyst for Suzuki-Miyaura reaction

Polymers containing the structure of N-heterocyclic carbenes (NHCs) have attracted much interest due to their superior complexing ability to metal ions and good recyclability, which make them promising candidates as solid supporters. Herein, we developed an easy method to synthesize polyimidazolium chloride salt (PImCl) via one-step method in mild conditions. After PImCl was chelated with palladium chloride in 3-chloropyridine, this NHC-Pd polymer was employed as the solid catalyst for Suzuki reactions of aryl bromides and phenylboronic acid. The catalytic activity of the NHC-Pd polymer was high for many different substrates. Moreover, the Suzuki reaction of 4-bromoanisole with phenylboronic acid could be catalyzed by this NHC-Pd polymer in mild conditions. Furthermore, this solid catalyst could be easily isolated by centrifugal separation. After several recycling runs, the catalytic activity decreased little. Compared with the conventional methods, this method was much simpler and more efficient, which showed enormous potential in preparing new heterogeneous supporter of porous polyimidazolium chloride salt.

Decarbonylative Suzuki-Miyaura Cross-Coupling of Aroyl Chlorides

Herein, we report a catalyst system for Pd-catalyzed decarbonylative Suzuki-Miyaura cross-coupling of aroyl chlorides with boronic acids to furnish biaryls. This strategy is suitable for a broad range of common aroyl chlorides and boronic acids. The synthetic utility is highlighted in the direct late-stage functionalization of pharmaceuticals and natural products capitalizing on the presence of carboxylic acid moiety. Extensive mechanistic and DFT studies provide key insight into the reaction mechanism and high decarbonylative cross-coupling selectivity.

Biguanide/Pd(OAc)2 immobilized on magnetic nanoparticle as a recyclable catalyst for the heterogeneous Suzuki reaction in aqueous media

Immobilization of Pd(II) ions on magnetite nanoparticle (MNP) has been simply achieved through a surface modification of Fe3O4 nanoparticle with a biguanide. This surface-modified nanoparticle was characterized by various techniques such as TEM, XRD, VSM, TGA, elemental analyzer, atomic absorption spectroscopy, N2 adsorption-desorption (BET and BJH), and FT-IR. This nanosolid exhibits excellent catalytic activity for heterogeneous Suzuki reaction in aqueous media, and could be easily separated by an external magnet and reused for several times. TEM study of the recovered catalyst showed the preservation of the support core-shell structure and the good dispersion of the produced palladium nanoparticles.