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Methyl 2,5-dichloroisonicotinate is a chemical compound with the molecular formula C7H5Cl2NO2. It is a derivative of isonicotinic acid, characterized by its two chlorine atoms and a methyl ester group attached to the isonicotinate ring. Methyl 2,5-dichloroisonicotinate is known for its unique chemical and reactivity properties, making it a versatile intermediate in organic synthesis and pharmaceutical research.

623585-74-0

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623585-74-0 Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2,5-dichloroisonicotinate is used as an intermediate in the production of various pharmaceuticals. Its unique chemical properties and reactivity make it a valuable component in the synthesis of new drugs and chemical compounds.
Used in Agrochemical Industry:
Methyl 2,5-dichloroisonicotinate is also used in the development of agrochemicals. Its versatile nature allows it to be incorporated into the synthesis of various compounds used in agriculture for pest control and crop protection.
Used in Organic Synthesis:
Methyl 2,5-dichloroisonicotinate is used as a key intermediate in organic synthesis. Its unique structure and reactivity properties enable the creation of a wide range of organic compounds for various applications across different industries.

Check Digit Verification of cas no

The CAS Registry Mumber 623585-74-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,3,5,8 and 5 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 623585-74:
(8*6)+(7*2)+(6*3)+(5*5)+(4*8)+(3*5)+(2*7)+(1*4)=170
170 % 10 = 0
So 623585-74-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H5Cl2NO2/c1-12-7(11)4-2-6(9)10-3-5(4)8/h2-3H,1H3

623585-74-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 2,5-dichloroisonicotinate

1.2 Other means of identification

Product number -
Other names methyl 2,5-dichloropyridine-4-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:623585-74-0 SDS

623585-74-0Relevant articles and documents

PLASMA KALLIKREIN INHIBITORS AND USES THEREOF

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Paragraph 0911; 0912, (2021/03/19)

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Achieving High 1H Nuclear Hyperpolarization Levels with Long Lifetimes in a Range of Tuberculosis Drug Scaffolds

Norcott, Philip,Rayner, Peter J.,Green, Gary G. R.,Duckett, Simon B.

supporting information, p. 16990 - 16997 (2017/11/20)

Despite the successful use of isoniazid, rifampicin, pyrazinamide and ethambutol in the treatment of tuberculosis (TB), it is a disease of growing global concern. We illustrate here a series of methods that will dramatically improve the magnetic resonance imaging (MRI) detectability of nineteen TB-relevant agents. We note that the future probing of their uptake and distribution in vivo would be expected to significantly enhance their efficacy in disease treatment. This improvement in detectability is achieved by use of the parahydrogen based SABRE protocol in conjunction with the 2H-labelling of key sites within their molecular structures and the 2H-labelling of the magnetization transfer catalyst. The T1 relaxation times and polarization levels of these agents are quantified under test conditions to produce a protocol to identify structurally optimized motifs for future detection. For example, deuteration of the 6-position of a pyrazinamide analogue leads to a structural form that exhibits T1 values of 144.5 s for 5-H with up to 20 % polarization. This represents a >7-fold extension in relaxation time and almost 10-fold improvement in polarization level when compared to its unoptimized structure.

PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS

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Page/Page column 55, (2013/06/05)

The present patent application is directed to bicyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (m PGES-1) enzyme and are theref

Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors

Hanan, Emily J.,Fucini, Raymond V.,Romanowski, Michael J.,Elling, Robert A.,Lew, Willard,Purkey, Hans E.,VanderPorten, Erica C.,Yang, Wenjin

scheme or table, p. 5186 - 5189 (2009/05/07)

A series of 2-amino-isoxazolopyridines was designed and synthesized as Polo-like kinase (Plk) inhibitors. Key SAR and crystallographic data are discussed. More advanced analogues inhibit Plk1 with good enzymatic activity and modest cell-based activity. Differential selectivity among the three Plk isoforms is observed.

VIRAL POLYMERASE INHIBITORS

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Page/Page column 83, (2009/01/20)

The present invention relates to viral polymerase inhibitors, in particular inhibitors of viral polymerases within the Flaviviridae family such as hepatitis C virus (HCV), processes for their preparation and their use in the treatment of infections.

SUBSTITUTED PYRROLE DERIVATIVE

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Page/Page column 92, (2010/11/08)

The present invention provides a novel pyrrole derivative having excellent androgen receptor antagonism, which is represented by the formula (I): wherein R1represents a hydrogen atom, a cyano group or a group represented by the formula COORA (wherein RA represents an optional substituted C1-6 alkyl group), R2 and R4 are the same or different, and each represents a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a trifluoromethyl group, an amino-C1-6 alkyl group, a mono-or di-substituted amino-C1-6 alkyl group, an optionally halogenated C1-6 alkyl group substituted with an optionally substituted hydroxyl group, a C2-6 alkenyl group substituted with an optionally substituted hydroxyl group, a C1-6 alkyl group substituted with an optionally substituted and optionally oxidized thiol group, an optionally substituted with and optionally oxidized thiol group, a cyano group, an acyl group, an optionally substituted oxazolyl group or a 1,3-dioxolan-2-yl group, R3 represents a group represented by the formula (a): (wherein X represents a halogen atom, Y represents a carbon atom or a nitrogen atom, Alk represents an optionally substituted C 1-4 alkylene group, and RB represents a hydrogen atom or an acyl group), and R5 represents a phenyl group which has a cyano group at a 4-position or a 3-position thereof, and may be further substituted, or a salt thereof. The present invention also provides an androgen receptor antagonist containing the pyrrole derivative, or a salt thereof.

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