88912-26-9

Usage

InChI:InChI=1/C6H3Cl2NO2/c7-4-2-9-5(8)1-3(4)6(10)11/h1-2H,(H,10,11)

Upstream product

• 16110-09-1 2,5 dichloropyridine 
• 124-38-9 carbon dioxide 

Downstream Products

• 503555-53-1 8-[(2,5-dichloroisonicotinoyl)amino]-1-(4-fluoro-phenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide 
• 1086031-12-0 C₁₉H₁₇N₃O 
• 1086030-27-4 C₁₃H₁₁ClN₂O 
• 623585-74-0 2,5-dichloroisonicotinic acid methyl ester 
• 2123489-30-3 (5-chloro-2-(2-(methylamino)thiazol-4-yl)-pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone 
• 88912-22-5 5-chloro-2-methoxyisonicotinic acid 
• 866039-42-1 (2,5-dichloropyridin-4-yl)methanol 
• 894074-89-6 methyl 2-(bromomethyl)-5-chloroisonicotinate 
• 1094341-93-1 3-chloro-5-[(6-chloro-3-{[5-(2,5-dichloro-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 
• 1273318-70-9 C₂₅H₁₈Cl₃N₅O₃ 
• 1273318-68-5 C₂₅H₁₈Cl₃N₅O₃ 
• 1273318-67-4 8-(2,5-dichloroisonicotinamido)-1-(4-methoxyphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide 

Relevant academic research and scientific papers

NOVEL COMPOSITIONS AND METHODS OF USE

Described herein are novel enzyme inhibitors. In some embodiments the enzyme inhibitors are integrase inhibitors, particularly HIV integrase inhibitors. Also described herein are compositions containing them and methods of using them. Thus, the compounds and compositions described herein are useful for the in vitro and in vivo inhibition of HIV integrase as a method of treating or preventing HIV, AIDS or related disorders.

VIRAL POLYMERASE INHIBITORS

The present invention relates to viral polymerase inhibitors, in particular inhibitors of viral polymerases within the Flaviviridae family such as hepatitis C virus (HCV), processes for their preparation and their use in the treatment of infections.

NOVEL ANXIOLYTIC COMPOUNDS

The present invention relates to chemical compounds of general formula (I) which may possess useful therapeutic activity in a range of central nervous system disorders, and in particular, anxiety disorders.

Strategies for the selective functionalization of dichloropyridines at various sites

Whereas 2,3-dichloropyridine and 2,5-dichloro-4-(lithiooxy)-pyridine undergo deprotonation exclusively at the 4- and 2-positions, respectively, optional site selectivity can be implemented with 2,5- and 3,4-dichloropyridine (which are attacked, depending on the choice of the reagents, at either the 4- or 6- and either the 2- and 5-positions, respectively). Upon treatment with lithium diisopropylamide, 2,4-dichloro-3-iodopyridine, 3,5-dichloro-4-bromopyridine and 2,6-dichloro-3-iodopyridine afford 5-, 2- and 4-lithiated intermediates, but the latter isomerize instantaneously to species in which lithium and iodine have swapped places, the driving force being the low basicity of C-Li bonds when flanked by two neighboring halogens.

1-heterocyclic bicyclo-octanes

Pesticidal bicyclo-octanes are of the formula STR1 where R is a substituted or unsubstituted aliphatic or aromatic group, R' and R3 are H or a substituted or unsubstituted aliphatic or aromatic group, R2 is a substituted or unsubstituted heterocyclic group containing at least one ring nitrogen and is preferably a 3- or 4- pyridyl group, Z is CH2 CH2, CH2 O--CH2 S or COCH2 or CH(OR5)CH2 where R5 is H, alkyl, acyl or carbamoyl at Y and Y' are O or S(O)m where m is 0, 1 or 2. Various methods for their preparation are described.