88912-26-9

Basic information

• Product Name: 2,5-Dichloroisonicotinic acid
• Synonyms: 2,5-DICHLOROPYRIDINE-4-CARBOXYLIC ACID;2,5-DICHLOROISONICOTINIC ACID;2.5-Dichloro-4-pyridine carboxlic acid;2,5-Dichloro-4-pyridinecarboxylic acid;2,5-Dichloroisocotinic acid;2,5-DICHLOROISONICOTINIC ACID / 2,5-DICHLOROPYRIDINE-4-CARBOXYLIC ACID;2,5-Dichloropyridine-4-carboxylic acid ,97%;2,5-Dichloropyridine-4-carboxylic acid, 4-Carboxy-2,5-dichloropyridine
• CAS NO: 88912-26-9
• Molecular Formula: C₆H₃Cl₂NO₂
• Molecular Weight: 192
• EINECS: -0
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Niacin;Chloropyridines;Halopyridines;pyridine;Picolinic acid series;Pyridines
• Mol File: 88912-26-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 236-238°C
• Boiling Point: 406.014 °C at 760 mmHg
• Flash Point: 199.35 °C
• Appearance: /
• Density: 1.612 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.49±0.25(Predicted)
• CAS DataBase Reference: 2,5-Dichloroisonicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dichloroisonicotinic acid(88912-26-9)
• EPA Substance Registry System: 2,5-Dichloroisonicotinic acid(88912-26-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 88912-26-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H3Cl2NO2/c7-4-2-9-5(8)1-3(4)6(10)11/h1-2H,(H,10,11)

Upstream product

• 16110-09-1 2,5 dichloropyridine 
• 124-38-9 carbon dioxide 

Downstream Products

• 1086031-12-0 C₁₉H₁₇N₃O 
• 1086030-27-4 C₁₃H₁₁ClN₂O 
• 88912-22-5 5-chloro-2-methoxyisonicotinic acid 
• 866039-42-1 (2,5-dichloropyridin-4-yl)methanol 
• 894074-89-6 methyl 2-(bromomethyl)-5-chloroisonicotinate 
• 1094341-93-1 3-chloro-5-[(6-chloro-3-{[5-(2,5-dichloro-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 
• 1273318-70-9 C₂₅H₁₈Cl₃N₅O₃ 
• 1273318-68-5 C₂₅H₁₈Cl₃N₅O₃ 
• 1273318-67-4 8-(2,5-dichloroisonicotinamido)-1-(4-methoxyphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide 
• 1273318-72-1 C₂₅H₁₉Cl₂N₅O₃ 
• 503555-53-1 8-[(2,5-dichloroisonicotinoyl)amino]-1-(4-fluoro-phenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide 
• 623585-74-0 2,5-dichloroisonicotinic acid methyl ester 

Relevant articles and documents

NOVEL COMPOSITIONS AND METHODS OF USE

Described herein are novel enzyme inhibitors. In some embodiments the enzyme inhibitors are integrase inhibitors, particularly HIV integrase inhibitors. Also described herein are compositions containing them and methods of using them. Thus, the compounds and compositions described herein are useful for the in vitro and in vivo inhibition of HIV integrase as a method of treating or preventing HIV, AIDS or related disorders.

NOVEL ANXIOLYTIC COMPOUNDS

The present invention relates to chemical compounds of general formula (I) which may possess useful therapeutic activity in a range of central nervous system disorders, and in particular, anxiety disorders.

1-heterocyclic bicyclo-octanes

Pesticidal bicyclo-octanes are of the formula STR1 where R is a substituted or unsubstituted aliphatic or aromatic group, R' and R3 are H or a substituted or unsubstituted aliphatic or aromatic group, R2 is a substituted or unsubstituted heterocyclic group containing at least one ring nitrogen and is preferably a 3- or 4- pyridyl group, Z is CH2 CH2, CH2 O--CH2 S or COCH2 or CH(OR5)CH2 where R5 is H, alkyl, acyl or carbamoyl at Y and Y' are O or S(O)m where m is 0, 1 or 2. Various methods for their preparation are described.