624729-63-1

Basic information

• Product Name: tert-butyl 7-ethoxynaphthalen-1-ylcarbaMate
• Synonyms: tert-butyl 7-ethoxynaphthalen-1-ylcarbaMate
• CAS NO: 624729-63-1
• Molecular Formula: C17H21NO3
• Molecular Weight: 287.35354
• Mol File: 624729-63-1.mol

Chemical Properties

• Boiling Point: 386.7±15.0 °C(Predicted)
• Appearance: /
• Density: 1.135±0.06 g/cm3(Predicted)
• PKA: 14.02±0.43(Predicted)
• CAS DataBase Reference: tert-butyl 7-ethoxynaphthalen-1-ylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 7-ethoxynaphthalen-1-ylcarbaMate(624729-63-1)
• EPA Substance Registry System: tert-butyl 7-ethoxynaphthalen-1-ylcarbaMate(624729-63-1)

Safety Data

• Hazardous Substances Data: 624729-63-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 7-ethoxynaphthalen-1-ylcarbaMate is used as a pharmaceutical intermediate for the development of new drugs. Its unique structure and properties may contribute to the discovery of novel therapeutic agents with potential applications in treating various diseases.
Used in Chemical Research:
Tert-butyl 7-ethoxynaphthalen-1-ylcarbaMate is used as a research compound in chemical studies. Its structure and properties can provide insights into the synthesis and reactivity of naphthylcarbamate derivatives, which may lead to the development of new organic compounds and materials.
Used in Organic Synthesis:
Tert-butyl 7-ethoxynaphthalen-1-ylcarbaMate is used as a building block in organic synthesis. Its presence of a tert-butyl group, an ethoxy group, and a naphthalene ring allows for various chemical reactions and modifications, enabling the synthesis of a wide range of organic compounds with potential applications in different industries.

Upstream product

• 118-46-7 8-amino-2-naphthol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 75-03-6 ethyl iodide 
• 301548-32-3 t-butyl (7-hydroxynaphthalen-1-yl)carbamate 

Downstream Products

• 624729-64-2 7-ethoxynaphthalen-1-amine 
• 624729-74-4 8-amino-3,4-dihydronaphthalen-2(1H)-one 

Relevant articles and documents

Tetrahydro-naphthols as orally available TRPV1 inhibitors

Starting from a naphthol-based lead series with low oral bioavailability, we have identified potent TRPV1 antagonists with oral bioavailability in rats. These compounds emerged from SAR studies aimed at replacing the lead's phenol structure whilst maintai

SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted aromatic carboxamide and urea derivatives, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions (formula (I)).

ANTAGONISTS OF THE VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USES THEREOF

The present invention is directed to compounds of formula (I) (I) wherein variables W, X, Y, D, A, n, R1, R2 and R9 are as defined in the description.

TETRAHYDRO-NAPHTHALENE AND UREA DERIVATIVES

This invention relates to tetrahydro-naphthalene and urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene and urea derivatives of the present invention have vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD). BHC 03 2 001-Foreign-Countries - 66 - BHC 03 2 001-Foreign-Countries - 65 -

TETRAHYDRO-NAPHTHALENE AND UREA DERIVATIVES

This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein # represents the connection position to the molecule and Q1a, Q2a, Q3a and Q4a are defined, and E represents formula (IV) or (V) wherein # represents the connection position to the molecule and Q1b, Q2b, Q3b, Q4b, Q5b, R1b, na, ma, Xa and Ra are defined.

TETRAHYDRO-NAPHTHALENE DERIVATIVES AS VANILLOID RECEPTOR ANTAGONISTS

This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antago

TETRAHYDRO-NAPHTHALENE DERIVATIVES

This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antago

HYDROXY-TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES

This invention relates to hydroxy-tetrahydro-naphthalenylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The hydroxy-tetrahydro-naphthalenylurea derivatives of the present invention have an excelle

HYDROXY TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES

This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antago