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626604-39-5

GSK-3β Inhibitor XI is a potent and selective inhibitor of glycogen synthase kinase-3 beta (GSK-3β), a key enzyme involved in various signaling pathways. This small molecule compound has been extensively studied for its potential therapeutic applications in a wide range of diseases, including cancer, neurological disorders, and inflammatory conditions. By blocking GSK-3β activity, GSK-3β Inhibitor XI can modulate multiple cellular processes, such as cell proliferation, apoptosis, and inflammation, making it a promising target for drug development. Its high selectivity and potency make it a valuable tool for researchers studying GSK-3β signaling and exploring potential therapeutic interventions.

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  • 626604-39-5 Structure

  • Basic information

    1. Product Name: GSK-3β Inhibitor XI
    2. Synonyms: GSK-3β Inhibitor XI;4-[1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-(pyrazin-2-yl)pyrrole-2,5-dione;GSK 3B Inhibitor XI
    3. CAS NO:626604-39-5
    4. Molecular Formula: C18H15N5O3
    5. Molecular Weight: 349.3434
    6. EINECS: -0
    7. Product Categories: Other enzyme inhibitors and activators
    8. Mol File: 626604-39-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: GSK-3β Inhibitor XI(CAS DataBase Reference)
    10. NIST Chemistry Reference: GSK-3β Inhibitor XI(626604-39-5)
    11. EPA Substance Registry System: GSK-3β Inhibitor XI(626604-39-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 626604-39-5(Hazardous Substances Data)

626604-39-5 Usage

Uses

Used in Pharmaceutical Industry:
GSK-3β Inhibitor XI is used as a therapeutic agent for the treatment of various diseases, including cancer, neurological disorders, and inflammatory conditions, due to its ability to modulate multiple cellular processes and block GSK-3β activity.
Used in Research Applications:
GSK-3β Inhibitor XI is used as a research tool for studying GSK-3β signaling pathways and exploring potential therapeutic interventions, given its high selectivity and potency in inhibiting GSK-3β activity.

Check Digit Verification of cas no

The CAS Registry Mumber 626604-39-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,6,6,0 and 4 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 626604-39:
(8*6)+(7*2)+(6*6)+(5*6)+(4*0)+(3*4)+(2*3)+(1*9)=155
155 % 10 = 5
So 626604-39-5 is a valid CAS Registry Number.

626604-39-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-[1-(3-hydroxypropyl)pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-ylpyrrole-2,5-dione

1.2 Other means of identification

Product number -
Other names 3-(1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-yl-pyrrole-2,5-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:626604-39-5 SDS

626604-39-5Downstream Products

626604-39-5Relevant articles and documents

Substituted pyrroline kinase inhibitors

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Page 40, (2008/06/13)

The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.

Design, synthesis, and biological evaluation of novel 7-azaindolyl- heteroaryl-maleimides as potent and selective glycogen synthase kinase-3β (GSK-3β) inhibitors

O'Neill, David J.,Shen, Lan,Prouty, Catherine,Conway, Bruce R.,Westover, Lori,Xu, Jun Z.,Zhang, Han-Cheng,Maryanoff, Bruce E.,Murray, William V.,Demarest, Keith T.,Kuo, Gee-Hong

, p. 3167 - 3185 (2007/10/03)

Two approaches were developed to synthesize the novel 7-azaindolyl- heteroarylmaleimides. The first approach was based upon the palladium-catalyzed Suzuki cross-coupling or Stille cross-coupling of 2-chloro-maleimide 5 with various arylboronic acids or ar

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