62802-38-4

Basic information

• Product Name: 5-BROMO-2-FLUOROPYRIMIDINE
• Synonyms: 5-BROMO-2-FLUOROPYRIMIDINE;5-Bromo-2-fluoropyrimidine ,97%;5-Bromo-2-fluoropyrimidne;5-Bromo-2-fluoro-1,3-diazine
• CAS NO: 62802-38-4
• Molecular Formula: C₄H₂BrFN₂
• Molecular Weight: 176.97
• EINECS: 1312995-182-4
• Product Categories: Pyrimidine;Organohalides
• Mol File: 62802-38-4.mol

Chemical Properties

• Melting Point: 90-93℃
• Boiling Point: 270.8 °C at 760 mmHg
• Flash Point: 117.6 °C
• Appearance: /
• Density: 1.838 g/cm³
• Vapor Pressure: 0.117mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: -2.90±0.22(Predicted)
• CAS DataBase Reference: 5-BROMO-2-FLUOROPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-FLUOROPYRIMIDINE(62802-38-4)
• EPA Substance Registry System: 5-BROMO-2-FLUOROPYRIMIDINE(62802-38-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 62802-38-4(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow solid

InChI:InChI=1/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H

Upstream product

• 38353-06-9 5-bromopyrimidin-2-ol 
• 7752-82-1 5-bromo-2-aminopyrimidine 

Downstream Products

• 1034923-97-1 2-amino-5-[3-(2-fluoropyrimidin-5-yl)phenyl]-3-methyl-5-(4-trimethylsilylphenyl)imidazol-4-one 
• 14001-72-0 (5-bromo-pyrimidin-2-yl)-tert-butyl-amine 
• 62850-13-9 2-fluoro-5-phenylpyrimidine 
• 14305-25-0 5-bromopyrimidine-2-thiol 
• 433683-47-7 5-bromo-2-(2,2,2-trifluoroethoxy)pyrimidine 
• 38373-55-6 benzyl-(5-bromo-pyrimidin-2-yl)-amine 
• 38353-06-9 5-bromopyrimidin-2-ol 

Relevant articles and documents

Preparation method 2 - methyl -5 -bromopyrimidine

The invention specifically discloses a preparation method of 2 - methyl -5 -bromopyrimidine, and belongs to the technical field of organic synthesis. The method comprises the following steps: a) taking 2 - amino -5 -bromopyrimidine as a raw material, carrying out diazotization reaction or Schedman reaction or 2 - hydroxyl -5 -bromopyrimidine as a raw material to obtain 2 -halo -5 -bromopyrimidine through a halogenated reagent. b) The carboxylic diester is substituted with 2 - halo -5 - bromopyrimidine to give 2-position substituted product. c) The last 2 -bit substituted product is reacted under basic, high temperature conditions to give 2 - methyl -5 - bromopyrimidine. The method has the advantages of easily available raw materials, low cost, simple flow and potential industrial amplification prospect.

PhenoFluor: Practical synthesis, new formulation, and deoxyfluorination of heteroaromatics

We report a practical synthesis method of the reagent PhenoFluor on decagram scale, provide a new formulation of PhenoFluor as a toluene solution, which should decrease challenges associated with the moisture sensitivity of the reagent, and expand the substrate scope of deoxyfluorination with PhenoFluor to heteroaromatics.