CONVENIENT METHOD FOR THE PREPARATION OF 2-PHENACYLPYRIDINES
2-Phenacylpyridines (3) were prepared from 2-(trimethylsilylmethyl)pyridine (1) and p-substituted benzonitriles (2) (X = H, Cl CH3, OCH3) in high yields (70 ca. 90percent)under a mild condition (LDA/THF, -75 deg C).The method was compared with a reaction of α-picoline with (2) under the same condition.The keto-enol tautomerism of (3) were also discussed by means of the nmr spectra.
Konakahara, Takeo,Takagi, Yukio
p. 393 - 396
(2007/10/02)
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