- N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]
-
A ruthenium complex [(p-cymene)Ru(2,2′-bpyO)(H2O)] was found to be a general and efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate salt. Moreover, a series of sensitive substituents, such as nitro, ester, cyano, and vinyl groups, were tolerated under present conditions. It was confirmed that OH units in the ligand are crucial for the catalytic activity. Notably, this research exhibited the potential of metal-ligand bifunctional ruthenium catalysts for the hydrogen autotransfer process.
- Liu, Peng,Tung, Nguyen Thanh,Xu, Xiangchao,Yang, Jiazhi,Li, Feng
-
p. 2621 - 2631
(2021/02/27)
-
- Controlled anchoring of (Phenylureido)sulfonamide-based receptor moieties: An impact of binding site multiplication on complexation properties
-
The repetition of urea-based binding units within the receptor structure does not only lead to monomer properties multiplication. As confirmed by spectroscopic studies, UV-Vis and1H-NMR in classical or competitive titration mode, the attachment
- ?t’astná, Lucie ?ervenková,Cu?ínová, Petra,Eigner, Václav,Krupková, Alena,Müllerová, Monika,Salvadori, Karolína,Stra?ák, Tomá?
-
-
- Catalyst-Free Visible-Light-Mediated Iodoamination of Olefins and Synthetic Applications
-
Herein we report a catalyst- and metal-free visible-light-mediated protocol enabling the iodoamination of miscellaneous olefins. This protocol is characterized by high yields under environmentally benign reaction conditions utilizing commercially available substrates and a green and biodegradable solvent. Furthermore, the protocol allows for late-stage functionalization of bioactive molecules and can be scaled to gram quantities of product, which offers manifold possibilities for further transformations, including morpholine, piperidine, pyrrolidine, and aziridine synthesis.
- Engl, Sebastian,Reiser, Oliver
-
supporting information
p. 5581 - 5586
(2021/07/26)
-
- Copper-catalyzed oxidative methylation of sulfonamides by dicumyl peroxide
-
A novel and facile copper-catalyzed methylation of sulfonamides was herein demonstrated. The practical transformation took place readily under the oxidative conditions, and N-methyl amides (23 examples) were successfully furnished in high efficiency (up to 90% yields). Dicumyl peroxide was considered to act not only as the oxidant in the system, but also methyl donor for the methylation protocol.
- Che, Shiying,Zhu, Qiao,Luo, Zhenghong,Lian, Yan,Zhao, Zijian
-
p. 935 - 942
(2021/01/05)
-
- MACROCYCLIC COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS
-
Compounds, methods of use, and processes for making inhibitors of complement factor D or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade. The inhibitors of factor D described herein reduce excessive activation of complement.
- -
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Page/Page column 453; 545; 546
(2020/03/29)
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- Arylation and alkenylation of activated alkyl halides using sulfonamides
-
A variety of quaternary aryl amino acid derivatives can be synthesised using tandem SN2/Smiles rearrangement chemistry involving aryl sulfonamides and α-chloro carbonyl compounds. The reaction harnesses a sulfur dioxide extrusion pathway to construct a C-N and C-Caryl bond under simple conditions with no requirement for organometallics or transition metal catalysts. The reaction is also successful for alkenyl sulfonamides, producing sterically congested quaternary alkene amino acid derivatives.
- Greaney, Michael F.,Johnson, Stuart,Kovács, Ervin
-
supporting information
p. 3222 - 3224
(2020/03/23)
-
- NLRP MODULATORS
-
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.
- -
-
Page/Page column 337; 338
(2020/01/31)
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- NLRP MODULATORS
-
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein, useful to treat connected to the modulation of NRLP3.
- -
-
Page/Page column 346; 352
(2020/01/31)
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- A Cascade Reaction of Michael Addition and Truce-Smiles Rearrangement to Synthesize Trisubstituted 4-Quinolone Derivatives
-
A novel transition-metal-free cascade reaction to synthesize 4-quinolone derivatives has been demonstrated. Michael addition and Truce-Smiles rearrangement are included in this protocol, providing a broad scope of 4-quinolones in moderate-to-excellent yields. This work serves as an example of the use of sulfonamides through Truce-Smiles rearrangement to build heterocyclic compounds under mild conditions.
- Xie, Caixia,Yang, Di,Wang, Xinfeng,Ma, Chen
-
p. 14937 - 14944
(2020/12/02)
-
- Metal-Free β-Amino Alcohol Synthesis: A Two-step Smiles Rearrangement
-
A novel method for the synthesis of β-amino alcohols has been demonstrated under mild reaction conditions with a broad scope via a two-step Smiles rearrangement. What is more, theoretical calculations have been performed to confirm the rationality of the mechanism. The method has been proved to be notably effective for N-arylated amino alcohols, which are difficult to synthesize by traditional methods.
- Yang, Di,Xie, Cai-Xia,Wu, Xiao-Tian,Fei, Luo-Ran,Feng, Lei,Ma, Chen
-
supporting information
p. 14905 - 14915
(2020/11/13)
-
- Unified Approach to the Chemoselective α-Functionalization of Amides with Heteroatom Nucleophiles
-
Functionalization at the α-position of carbonyl compounds has classically relied on enolate chemistry. As a result, the generation of a new C-X bond, where X is more electronegative than carbon requires an oxidation event. Herein we show that, by rendering the α-position of amides electrophilic through a mild and chemoselective umpolung transformation, a broad range of widely available oxygen, nitrogen, sulfur, and halogen nucleophiles can be used to generate α-functionalized amides. More than 60 examples are presented to establish the generality of this process, and calculations of the mechanistic aspects underline a fragmentation pathway that accounts for the broadness of this methodology.
- Gon?alves, Carlos R.,Lemmerer, Miran,Teskey, Christopher J.,Adler, Pauline,Kaiser, Daniel,Maryasin, Boris,González, Leticia,Maulide, Nuno
-
supporting information
p. 18437 - 18443
(2019/11/21)
-
- Copper(i)-catalyzed N-H olefination of sulfonamides for: N -sulfonyl enaminone synthesis
-
This communication reports copper-catalyzed N-H olefination of sulfonamides for enaminone synthesis using saturated ketones as olefin sources. With TEMPO derivatives and O2 as oxidants, this method provided an efficient way to produce various enaminones in good yields. Mechanistic studies helped figure out the stable intermediates and develop novel methodologies for the difunctionalization of saturated ketones.
- Liang, Xiao,Huang, Xin,Xiong, Mingteng,Shen, Kexin,Pan, Yuanjiang
-
supporting information
p. 8403 - 8406
(2018/08/03)
-
- Copper-Catalyzed Arylsulfonylation and Cyclizative Carbonation of N-(Arylsulfonyl)acrylamides Involving Desulfonative Arrangement toward Sulfonated Oxindoles
-
Sulfonated oxindoles are accessed by a Cu(OAc)2-catalyzed three-component reaction of N-(arylsulfonyl)acrylamides, DABSO, and aryldiazonium tetrafluoroborates. This transformation is triggered by the formation of arylsulfonyl radicals in situ from the reaction of aryldiazonium tetrafluoroborates and DABSO. Afterward, the sequential radical addition, radical cyclization, and desulfonylative 1,4-aryl migration take place to provide the final product by the formation of four new bonds in one pot. This procedure shows good functional group tolerance.
- Wang, Hepan,Sun, Song,Cheng, Jiang
-
supporting information
p. 5844 - 5847
(2017/11/10)
-
- Studies on the Synthesis of the Alkaloid (-)-Gilbertine via Indolidene Chemistry
-
A synthesis route to the pentacyclic alkaloid (-)-gilbertine, which features a cyclization cascade passing through a transient indolidene intermediate, was pursued. A key stereochemical relationship was set via a Nicholas-type enolate alkylation. Ultimately, undesired C-N cyclization thwarted the final projected C-C bond forming ring closure, and gilbertine could not be prepared by this route.
- Feldman, Ken S.,Folda, Tamara S.
-
supporting information
p. 4566 - 4575
(2016/07/06)
-
- Metal Free Bi(hetero)aryl Synthesis: A Benzyne Truce-Smiles Rearrangement
-
A new benzyne transformation is described that affords versatile biaryl structures without recourse to transition-metal catalysis or stoichiometric amounts of organometallic building blocks. Aryl sulfonamides add to benzyne upon fluoride activation, and then undergo an aryl Truce-Smiles rearrangement to afford biaryls with sulfur dioxide extrusion. The reaction proceeds under simple reaction conditions and has excellent scope for the synthesis of sterically hindered atropisomeric biaryl amines. All smiles: Metal-free biaryl synthesis is achieved by adding benzyne to arylsulfonamides. A Smiles rearrangement enables C-C bond formation, thus accessing a variety of functionalized biaryls under mild reaction conditions.
- Holden, Catherine M.,Sohel, Shariar M. A.,Greaney, Michael F.
-
supporting information
p. 2450 - 2453
(2016/02/18)
-
- HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES
-
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.
- -
-
Paragraph 000276
(2016/05/02)
-
- Oxidative debenzylation of N-benzyl amides and O-benzyl ethers using alkali metal bromide
-
The oxidative debenzylation of N-benzyl amides and O-benzyl ethers was promoted with high efficiency by a bromo radical formed through the oxidation of bromide from alkali metal bromide under mild conditions. This reaction provided the corresponding amides from N-benzyl amides and carbonyl compounds from O-benzyl ethers in high yields.
- Moriyama, Katsuhiko,Nakamura, Yu,Togo, Hideo
-
supporting information
p. 3812 - 3815
(2014/08/05)
-
- COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS
-
Described herein are compounds and compositions for the amelioration of arthritis or joint injuries by inducing mesenchymal stem cells into chondrocytes.
- -
-
Paragraph 0747
(2014/09/29)
-
- Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors
-
Screening of the NCI Diversity Set-1 identified PI-083 (NSC-45382) a proteasome inhibitor selective for cancer over normal cells. Focused libraries of novel compounds based on PI-083 chloronaphthoquinone and sulfonamide moieties were synthesized to gain a better understanding of the structure-activity relationship responsible for chymotrypsin-like proteasome inhibitory activity. This led to the demonstration that the chloronaphthoquinone and the sulfonamide moieties are critical for inhibitory activity. The pyridyl group in PI-083 can be replaced with other heterocyclic groups without significant loss of activity. Molecular modeling studies were also performed to explore the detailed interactions of PI-083 and its derivatives with the β5 and β6 subunits of the 20S proteasome. The refined model showed an H-bond interaction between the Asp-114 and the sulfonamide moiety of the PI-083 in the β6 subunit.
- Lawrence, Harshani R.,Kazi, Aslamuzzaman,Luo, Yunting,Kendig, Robert,Ge, Yiyu,Jain, Sanjula,Daniel, Kenyon,Santiago, Daniel,Guida, Wayne C.,Sebti, Said M.
-
experimental part
p. 5576 - 5592
(2010/09/15)
-
- Substituted inmidazoles as bombesin receptor subtype-3 modulators
-
Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.
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Page/Page column 87
(2010/02/17)
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- Establishment of heterolytic and homolytic Y-NO2 bond dissociation energy scales of nitro-containing compounds in acetonitrile: Chemical origin of NO2 release and capture
-
(Chemical Equation Presented) The first heterolytic and homolytic N(O)-NO2 bond dissociation energy scales of three types Y-nitro (Y = N, O) compounds and corresponding radical anions in acetonitrile were established by using titration calorimetry combined with relevant electrochemical data through proper thermodynamic cycles.
- Li, Xin,Zhu, Xiao-Qing,Zhang, Fan,Wang, Xiao-Xiao,Cheng, Jin-Pei
-
p. 2428 - 2431
(2008/09/20)
-
- N-methyl-N-nosyl-β3-amino acids
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(Chemical Equation Presented) N-Methyl-β3-amino acids are important building blocks in the synthesis of biologically active molecules. A very simple and efficient approach to transform natural α-amino acids into their corresponding N-methyl-βs
- Belsito, Emilia,Di Gioia, Maria L.,Greco, Antonella,Leggio, Antonella,Liguori, Angelo,Perri, Francesca,Siciliano, Carlo,Viscomi, Maria C.
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p. 4798 - 4802
(2008/02/05)
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- TRIAZOLE COMPOUNDS AS LIPOXYGENASE INHIBITORS
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There is provided compounds of formula (I) wherein W is an optionally substituted aryl or heteroaryl group, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15- lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
- -
-
Page/Page column 40
(2008/06/13)
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- SULFASALAZINE ANALOGUES AS NF-KB INHIBITORS
-
Use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use as a Nuclear Factor-kB (NF-kB) inhibitor formula (I), wherein: A has the following structure; formula (i) Z is -COOH5 -P(O)(OH)sub
- -
-
Page/Page column 24
(2008/06/13)
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- Nitroso group transfer from N-nitrososulfonamides to thiolate ions. Intrinsic reactivity
-
The nitroso group transfer from N-nitrososulfonamides to thiolate ions was studied. Based on the results, the reaction rate is strongly dependent on the nature of the leaving group (αlg ≈ - 1.30), but virtually independent of the basicity of th
- Adam,García-Río,Leis,Moreira
-
p. 8822 - 8829
(2007/10/03)
-
- Synthesis of phenyl arylsulfonyl-alkyl-dithiocarbamates and their hydrolytic reactivity in hydroxide and hydroperoxide media
-
Eight previously unreported phenyl arylsulfonyl-alkyl-dithiocarbamates were synthesized by treatment of arylsulfonamides with phenyl chlorodithioformate in an adaptation of a general amine acylation method. A kinetic investigation of their alkaline hydrolysis was performed and the experimental data are discussed. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.
- Norberto, Fatima,Araujo, M. Eduarda M.,Santos, Lidia,Jaime, Marta S. P.,Mateus, Pedro M. V.,Herves, Pablo
-
p. 4710 - 4714
(2007/10/03)
-
- In vivo imaging
-
A positron emission tomography (PET)-ready library of candidate pharmaceutical agents is provided which can be prepared by a multistep process wherein the final or penultimate step is a reaction using a PET-ready reagent or a plurality of PET-ready reagents. Methods of preparing and using the libraries are also provided.
- -
-
-
- Safety-catch linker strategies for the production of radiopharmaceuticals labeled with positron-emitting isotopes
-
A novel synthetic stratetegy for compounds labeled with the positron-emitting isotope carbon-11 is described. The use of precursors attached to a solid support via safety-catch linkers allows selective release of radiolabeled material, leaving unreacted precursor attached to the support. Two different linkers demonstrate the application to the preparation of radiolabeled N-alkyl tertiary amines and N-alkylsulfonamides. This technique is expected to lead to more widespread use of positron emission tomography for the in vivo analysis of compound behavior. Copyright
- Maclean, Derek,Zhu, Jiang,Chen, Mingying,Hale, Ron,Satymurthy, Nagichettiar,Barriot, Jorge R.
-
p. 10168 - 10169
(2007/10/03)
-
- The reversed Kenner linker: A new safety-catch linker for the preparation of N-alkyl sulfonamides
-
matrix presented A new strategy for the solid-phase synthesis of sulfonamides is described. The Kenner safety-catch strategy has been modified such that the carboxylic acid component remains attached to the solid support while the sulfonamide portion is released into solution. An initial demonstration of the scope of this strategy is presented, along with an analysis of the cleavage characteristics and extension to more elaborate products via Suzuki reaction and thiazolidinone synthesis.
- Maclean, Derek,Hale, Ron,Chen, Mingying
-
p. 2977 - 2980
(2007/10/03)
-
- Hydrolysis of aryl N-methyl-N-arylsulfonylcarbamates
-
Tertiary sulfonylcarbamates 1 were prepared by reaction of a sulfonamide anion with aryl chloroformates. These previously unreported compounds hydrolyse in aqueous media to the parent sulfonamide and phenol. The pH-rate profile shows both spontaneous and base-catalysed processes. The reaction is also catalysed by buffers. Kinetic data for the hydrolysis of these compounds by HO- are best interpreted in terms of a mechanism involving rate-limiting formation of a tetrahedral intermediate from nucleophilic attack of hydroxide ion at the carbamate carbonyl carbon atom. For the 4-nitrophenylsulfonyl compound 1h decomposition of the tetrahedral intermediate appears to be rate-limiting with the sulfonamide anion, rather than the phenoxide, functioning as the leaving group. The buffer-catalysed process is consistent with general base-catalysed attack of water at the carbamate carbonyl carbon atom.
- Araujo,Campelo,Iley,Norberto
-
p. 494 - 497
(2007/10/03)
-
- Nitroso group transfer from substituted N-methyl-N-nitrosobenzenesulfonamides to amines. Intrinsic and apparent reactivity
-
We have studied the nitroso group transfer from substituted N-methyl-N-nitrosobenzenesulfonamides to primary and secondary amines, observing that the rate of the reaction increases as a consequence of the presence of electron withdrawing groups on the aromatic ring of the nitrosating agents. The rate constants determined for the nitroso group transfer ktr, give good Bronsted-type relationships between log ktr (rate constant for nitroso group transfer) and pKa/R2NH2+ and pKa/leaving group. The study of the nitrosation processes of secondary amines catalyzed by ONSCN and denitrosation catalyzed by SCN-, in combination with the formation equilibrium of ONSCN, has enabled us to calculate the value of the equilibrium constant for the loss of the NO+ group from a protonated N-nitrosamine (pKNO/R2N+ HNO), which can be defined by analogy with pKa/R2NH2+. The value of pKNO/X-NO for the loss of the NO+ group from an N-methyl-N-nitrosobenzenesulfonamide was obtained in a similar way. By using values of ΔpKNO = pKNO/R2N+ HNO - pKNO/X-NO, we were able to calculate the equilibrium constant for the nitroso group transfer and characterize the transition state. On the basis of Bronsted-type correlations, we have obtained values of βnucl/norm and αlg/norm ? 0.55, showing a perfectly balanced transition state. In terms, of the Marcus theory, the calculation of the intrinsic barriers for the nitroso group transfer reaction shows that the presence of electron withdrawing groups on thearomatic ring of the N-methyl-N-nitrosobenzenesulfonamides does not cause these barriers to vary.
- Garcia-Rio,Leis,Moreira,Norberto
-
p. 381 - 390
(2007/10/03)
-
- Prodrugs of benzenesulfonamide-containing COX-2 inhibitors
-
Prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders.
- -
-
-
- Stability and nitrosation efficiency of substituted N-methyl-N-nitrosobenzenesulfonamides
-
A series of substituted N-methyl-N-nitrosobenzenesulfonamides [2,4,6-(CH3)3, 4-CH3O, 4-CH3 4-Cl and 4-NO2] were synthesized. All of them transfer their nitroso group to N-methylaniline in a quantitative manner, the more reactive being those substituted with electron-withdrawing groups, thus resembling some of the known alkyl nitrites. Studies of their acid denitrosation and base-catalysed hydrolysis demonstrated that the nitrosobenzenesulfonamides are fairly stable in aqueous media between pH 2 and 11. Their relative stability in aqueous media together with their ability to transfer the nitroso group to nucleophiles suggest their use as excellent alternatives to alkyl nitrites in both neutral and basic media.
- Garcia-Rio,Leis,Moreira,Norberto
-
p. 756 - 760
(2007/10/03)
-
- Nitrosation and denitrosation of substituted N-methylbenzenesulfonamides. Evidence of an imbalanced concerted mechanism
-
The kinetics of the nitrosation reaction of several substituted sulfonamides and of the denitrosation of the resulting products have been studied. The denitrosation rate is first-order with respect to both the nitroso compound and acid concentration and no effect of added nucleophiles was observed. The denitrosation reaction is general-acid catalysed, with a Bronsted parameter αd, of 0.7, which is independent of the substituents on the aromatic ring. Kinetic solvent isotope effects range from kH3O+d/ kD3O+d = 1.20 ± 0.05 to 2.04 ± 0.06 for denitrosation by L3O+ and from kAHd/kADd = 1.5 ± 0.2 to 2.3 ± 0.3 for denitrosation by dichloroacetic acid, which suggest that a rate-determining proton transfer is involved in this reaction. For nitrosation reaction, the absence of catalysis by nucleophilic anions, the observed general-base catalysis (βNO = 0.3) and the substituent effects suggest a concerted nitrosation-denitrosation process. The Leffler parameters obtained for N ... H bond formation (αnuc = 0.7) as well as for N ... N=O bond breaking (αlg = 0.17) are in favour of an imbalance in the transition state (αimbalance = 0.53) with the development of a positive charge on the nitrogen adjacent to the nitroso group.
- Garcia-Rio, Luis,Leis, J. Ramon,Moreira, Jose A.,Norberto, Fatima
-
p. 1613 - 1620
(2007/10/03)
-
- 1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase- 2
-
Series of 1,2-diarylpyrroles has been synthesized and found to contain very potent and selective inhibitors of the human cyclooxygenase-2 (COX-2) enzyme. The paper describes short and practical syntheses of the target molecules utilizing the Paal-Knorr reaction. Electrophilic substitution on 1 proceeds in a regioselective fashion, and the method was used to generate a number of tetrasubstituted pyrroles. Detailed SAR on the series has been studied by modifications of the aryl rings and the substituents in the pyrrole ring. Diarylpyrrole 1 is a very potent (COX-2, IC50 = 60 nm) and selective (COX-1/COX-2 = > 1700) inhibitor whereas the isomeric 2 is completely inactive against COX-2. Modifications of the substituents on the fluorophenyl ring in 1 yields very potent inhibitors of COX-2 (IC50 = 40- 80 nm) with excellent selectivity(1200 to >2500) vs COX-1, Analog 20 containing a sulfonamide group is an excellent inhibitor of COX-2 with an IC50 of 14 nm. Tetrasubstituted pyrroles containing groups such as COCF3, SO2CF3, or CH2OAr at position 3 in the pyrrole ring give excellent inhibitors (COX-2, IC50 = 30-120 nm). In vivo testing in the carrageenan- induced paw edema model in the rat establishes that the 1,2-diarylpyrroles are orally active antiinflammatory agents. Compound 3 is the most potent inhibitor of edema with an ED50 of 4.7 mpk.
- Khanna, Ish K.,Weier, Richard M.,Yu, Yi,Collins, Paul W.,Miyashiro, Julie M.,Koboldt, Carol M.,Veenhuizen, Amy W.,Currie, Jerry L.,Seibert, Karen,Isakson, Peter C.
-
p. 1619 - 1633
(2007/10/03)
-
- EFFECT OF STRUCTURE ON THE KINETICS AND MECHANISM OF THE ACID-CATALYZED DECOMPOSITION OF N-ALKYL-N-NITROBENZENESULFONAMIDES
-
The decomposition rate of a series of meta- and para-substituted N-alkyl-N-nitrobenzenesufonamides was determined by a spectrophotometric method in aqueous sulfuric acid.It was shown that the decomposition of the compounds takes place both by denitration and by cleavage of the N-S bond with the formation fo primary aliphatic N-nitrosamines.Electron-withdrawing substituents in the aromatic ring shift the process toward denitration.
- Drozdova, O. A.,Astrat'ev, A. A.,Kuznetsov, L. L.,Selivanov, V. F.
-
p. 671 - 675
(2007/10/02)
-