6319-45-5

Usage

Uses

Used in Pharmaceutical Industry:
N1-Methyl-4-nitrobenzene-1-sulfonamide is used as a chemical intermediate for the synthesis of various drugs and pharmaceuticals. Its unique molecular structure allows it to be a key component in the development of new medications, contributing to the advancement of healthcare and treatment options.
Used in Organic Chemistry Research:
In the field of organic chemistry, N1-Methyl-4-nitrobenzene-1-sulfonamide serves as a valuable compound for research purposes. It is utilized in the study of chemical reactions and mechanisms, providing insights into the behavior of nitrogen and sulfur organic compounds and their potential applications in various chemical processes.

InChI:InChI=1/C7H8N2O4S/c1-8-14(12,13)7-4-2-6(3-5-7)9(10)11/h2-5,8H,1H3

Upstream product

• 74-89-5 methylamine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 86674-15-9 C₇H₇N₃O₆S 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 210820-72-7 4-nitro-benzenesulfonic acid-(methyl-nitroso-amide) 
• 100-61-8 N-methylaniline 
• 67-56-1 methanol 
• 593-51-1 methylamine hydrochloride 
• 120-94-5 1-Methylpyrrolidine 
• 108-30-5 succinic acid anhydride 
• 14533-84-7 pentafluorophenyl trifloroacetate 
• 945014-90-4 N-methyl-N-nosyl-L-alanyldiazomethane 
• 74-88-4 methyl iodide 

Downstream Products

• 210820-72-7 4-nitro-benzenesulfonic acid-(methyl-nitroso-amide) 
• 86674-15-9 C₇H₇N₃O₆S 
• 27831-90-9 N-Acetylderivative of 4-nitrobenzenesulfonamide-N-methyl 
• 1709-52-0 N-methyl-4-aminobenzenesulfonamide 
• 211676-02-7 N-methyl-4-nitro-N-(p-tolyl)benzenesulfonamide 
• 211676-01-6 N-methyl-N-nosyl-m-toluidine 
• 211676-00-5 N-methyl-N-nosyl-o-toluidine 
• 64999-94-6 N-methyl-N-phenyl-4-nitrobenzene sulphonamide 
• 164032-14-8 N-chloromethyl-N-methyl-4-nitro-benzenesulfonamide 
• 17459-03-9 4-(N,N-dimethylaminosulfonyl)nitrobenzene 
• 1127943-68-3 N-{2-[3-bromo-4-hydroxy-5-(trimethylsilyl)phenyl]ethyl}-N-methyl-4-nitrobenzenesulfonamide 
• 1022155-68-5 N-{2-[4-(2,2-dimethylbutyl)-1-trityl-1H-imidazol-2-yl]-1-[4-(5-fluoropyridin-2-yl)phenyl]ethyl}-N-methyl-4-nitrobenzenesulfonamide 
• 1263313-58-1 4-chloro-N-[2-(2,2-dimethyl-propionyl)-phenyl]-N-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Controlled anchoring of (Phenylureido)sulfonamide-based receptor moieties: An impact of binding site multiplication on complexation properties

The repetition of urea-based binding units within the receptor structure does not only lead to monomer properties multiplication. As confirmed by spectroscopic studies, UV-Vis and1H-NMR in classical or competitive titration mode, the attachment

Catalyst-Free Visible-Light-Mediated Iodoamination of Olefins and Synthetic Applications

Herein we report a catalyst- and metal-free visible-light-mediated protocol enabling the iodoamination of miscellaneous olefins. This protocol is characterized by high yields under environmentally benign reaction conditions utilizing commercially available substrates and a green and biodegradable solvent. Furthermore, the protocol allows for late-stage functionalization of bioactive molecules and can be scaled to gram quantities of product, which offers manifold possibilities for further transformations, including morpholine, piperidine, pyrrolidine, and aziridine synthesis.

N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]

A ruthenium complex [(p-cymene)Ru(2,2′-bpyO)(H2O)] was found to be a general and efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate salt. Moreover, a series of sensitive substituents, such as nitro, ester, cyano, and vinyl groups, were tolerated under present conditions. It was confirmed that OH units in the ligand are crucial for the catalytic activity. Notably, this research exhibited the potential of metal-ligand bifunctional ruthenium catalysts for the hydrogen autotransfer process.

Copper-catalyzed oxidative methylation of sulfonamides by dicumyl peroxide

A novel and facile copper-catalyzed methylation of sulfonamides was herein demonstrated. The practical transformation took place readily under the oxidative conditions, and N-methyl amides (23 examples) were successfully furnished in high efficiency (up to 90% yields). Dicumyl peroxide was considered to act not only as the oxidant in the system, but also methyl donor for the methylation protocol.

MACROCYCLIC COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS

Compounds, methods of use, and processes for making inhibitors of complement factor D or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade. The inhibitors of factor D described herein reduce excessive activation of complement.

Arylation and alkenylation of activated alkyl halides using sulfonamides

A variety of quaternary aryl amino acid derivatives can be synthesised using tandem SN2/Smiles rearrangement chemistry involving aryl sulfonamides and α-chloro carbonyl compounds. The reaction harnesses a sulfur dioxide extrusion pathway to construct a C-N and C-Caryl bond under simple conditions with no requirement for organometallics or transition metal catalysts. The reaction is also successful for alkenyl sulfonamides, producing sterically congested quaternary alkene amino acid derivatives.

NLRP MODULATORS

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

NLRP MODULATORS

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein, useful to treat connected to the modulation of NRLP3.

A Cascade Reaction of Michael Addition and Truce-Smiles Rearrangement to Synthesize Trisubstituted 4-Quinolone Derivatives

A novel transition-metal-free cascade reaction to synthesize 4-quinolone derivatives has been demonstrated. Michael addition and Truce-Smiles rearrangement are included in this protocol, providing a broad scope of 4-quinolones in moderate-to-excellent yields. This work serves as an example of the use of sulfonamides through Truce-Smiles rearrangement to build heterocyclic compounds under mild conditions.

Metal-Free β-Amino Alcohol Synthesis: A Two-step Smiles Rearrangement

A novel method for the synthesis of β-amino alcohols has been demonstrated under mild reaction conditions with a broad scope via a two-step Smiles rearrangement. What is more, theoretical calculations have been performed to confirm the rationality of the mechanism. The method has been proved to be notably effective for N-arylated amino alcohols, which are difficult to synthesize by traditional methods.