6319-45-5

Basic information

• Product Name: N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE
• Synonyms: N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE;N-(4-NITROPHENYLSULFONYL)METHYLAMINE;Benzenesulfonamide, N-methyl-4-nitro-;Inchi=1/C7H8N2o4S/C1-8-14(12,13)7-4-2-6(3-5-7)9(10)11/H2-5,8H,1h
• CAS NO: 6319-45-5
• Molecular Formula: C₇H₈N₂O₄S
• Molecular Weight: 216.21442
• Mol File: 6319-45-5.mol
• Article Data: 37

Chemical Properties

• Melting Point: 105-106 °C
• Boiling Point: 377.7 °C at 760 mmHg
• Flash Point: 182.3 °C
• Appearance: /
• Density: 1.423 g/cm³
• Vapor Pressure: 6.6E-06mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.31±0.30(Predicted)
• CAS DataBase Reference: N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE(6319-45-5)
• EPA Substance Registry System: N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE(6319-45-5)

Safety Data

• Hazardous Substances Data: 6319-45-5(Hazardous Substances Data)

Usage

Description

N1-Methyl-4-nitrobenzene-1-sulfonamide, also known as 4-Nitrobenzene-1-sulfonamide, is a nitrogen and sulfur organic compound with a molecular structure that includes a benzene sulfonamide unit, an additional nitro group, and a methyl group. It is commonly found as a white solid powder at room temperature and is used in the production of various drugs and pharmaceuticals within the field of organic chemistry.

Uses

Used in Pharmaceutical Industry:
N1-Methyl-4-nitrobenzene-1-sulfonamide is used as a chemical intermediate for the synthesis of various drugs and pharmaceuticals. Its unique molecular structure allows it to be a key component in the development of new medications, contributing to the advancement of healthcare and treatment options.
Used in Organic Chemistry Research:
In the field of organic chemistry, N1-Methyl-4-nitrobenzene-1-sulfonamide serves as a valuable compound for research purposes. It is utilized in the study of chemical reactions and mechanisms, providing insights into the behavior of nitrogen and sulfur organic compounds and their potential applications in various chemical processes.

InChI:InChI=1/C7H8N2O4S/c1-8-14(12,13)7-4-2-6(3-5-7)9(10)11/h2-5,8H,1H3

Upstream product

• 210820-72-7 4-nitro-benzenesulfonic acid-(methyl-nitroso-amide) 
• 100-61-8 N-methylaniline 
• 67-56-1 methanol 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 593-51-1 methylamine hydrochloride 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 120-94-5 1-Methylpyrrolidine 
• 108-30-5 succinic acid anhydride 
• 14533-84-7 pentafluorophenyl trifloroacetate 
• 945014-90-4 N-methyl-N-nosyl-L-alanyldiazomethane 
• 74-88-4 methyl iodide 
• 86674-15-9 C₇H₇N₃O₆S 
• 74-89-5 methylamine 

Downstream Products

• 210820-72-7 4-nitro-benzenesulfonic acid-(methyl-nitroso-amide) 
• 1709-52-0 N-methyl-4-aminobenzenesulfonamide 
• 610800-48-1 (S)-methyl 2-(N-methyl-4-nitrobenzenesulfonamido)propanoate 
• 177536-70-8 4-(1'',3''Dioxolan-2''-yl)-2-methoxyazobenzol-4'-(N-allyl-N-methylsulfonsaeureamid) 
• 177536-69-5 4-(1'',3''Dioxolan-2''-yl)-2-methoxyazobenzol-4'-(N-methylsulfonsaeureamid) 
• 177536-55-9 4-Formyl-2-methoxyazobenzol-4'-(N-methylsulfonsaeureamid) 
• 164032-14-8 N-chloromethyl-N-methyl-4-nitro-benzenesulfonamide 
• 64999-94-6 N-methyl-N-phenyl-4-nitrobenzene sulphonamide 
• 211676-02-7 N-methyl-4-nitro-N-(p-tolyl)benzenesulfonamide 
• 211676-01-6 N-methyl-N-nosyl-m-toluidine 
• 211676-00-5 N-methyl-N-nosyl-o-toluidine 
• 69751-90-2 4'-chloro-N-methyl-4-nitrobenzenesulfonanilide 
• 177536-49-1 N-Methyl-4-nitrosobenzolsulfonsaeureamid 

Relevant articles and documents

Controlled anchoring of (Phenylureido)sulfonamide-based receptor moieties: An impact of binding site multiplication on complexation properties

The repetition of urea-based binding units within the receptor structure does not only lead to monomer properties multiplication. As confirmed by spectroscopic studies, UV-Vis and1H-NMR in classical or competitive titration mode, the attachment

N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]

A ruthenium complex [(p-cymene)Ru(2,2′-bpyO)(H2O)] was found to be a general and efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate salt. Moreover, a series of sensitive substituents, such as nitro, ester, cyano, and vinyl groups, were tolerated under present conditions. It was confirmed that OH units in the ligand are crucial for the catalytic activity. Notably, this research exhibited the potential of metal-ligand bifunctional ruthenium catalysts for the hydrogen autotransfer process.

Arylation and alkenylation of activated alkyl halides using sulfonamides

A variety of quaternary aryl amino acid derivatives can be synthesised using tandem SN2/Smiles rearrangement chemistry involving aryl sulfonamides and α-chloro carbonyl compounds. The reaction harnesses a sulfur dioxide extrusion pathway to construct a C-N and C-Caryl bond under simple conditions with no requirement for organometallics or transition metal catalysts. The reaction is also successful for alkenyl sulfonamides, producing sterically congested quaternary alkene amino acid derivatives.