- DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX
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To provide a dinuclear metal complex that can be synthesized simply and easily and has a proper anticancer action.SOLUTION: The present disclosure provides a dinucleating ligand represented by the following formula (I) and a dinuclear metal complex thereof (where each X may be the same or different to represent H, Cl, OMe, or, Me, Y is H, a phenyl group, a substituted carbamoyl group or the like).SELECTED DRAWING: None
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- DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX
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To provide a dinuclear metal complex that can be synthesized simply and easily and has a proper anticancer action.SOLUTION: The present disclosure provides a dinucleating ligand represented by the following formula (I) and a dinuclear metal complex thereof (where X is H or a substituted carbamoyl group, R1, R2, R3, and R4 independently represent H or a C1-8 linear or branched alkyl group).SELECTED DRAWING: None
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Paragraph 0048; 0062-0063
(2021/03/19)
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- Oxidative DNA Cleavage, Formation of μ-1,1-Hydroperoxo Species, and Cytotoxicity of Dicopper(II) Complex Supported by a p-Cresol-Derived Amide-Tether Ligand
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Metal complexes to promote oxidative DNA cleavage by H2O2 are desirable as anticancer drugs. A dicopper(II) complex of known p-cresol-derived methylene-tether ligand Hbcc [Cu2(bcc)]3+ did not promote DNA cleavag
- Kadoya, Yuki,Fukui, Katsuki,Hata, Machi,Miyano, Risa,Hitomi, Yutaka,Yanagisawa, Sachiko,Kubo, Minoru,Kodera, Masahito
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supporting information
p. 14294 - 14298
(2019/10/19)
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- Synthesis and NMR Spectroscopic Study of the Self-Aggregation of 2-Substituted Benzene-1,3,5-tricarboxamides
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The self-assembly of N,N′,N′-trialkylbenzene-1,3,5-tricarboxamides (BTAs) 1 or of "crowded" BTAs 11 and 12 lead to supramolecular columnar-stacked structures with attractive material properties. The introduction of three alkoxy groups is reported to reinf
- Invernizzi, Christian,Dalvit, Claudio,Stoeckli-Evans, Helen,Neier, Reinhard
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p. 5115 - 5127
(2015/08/18)
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- Dinuclear Ag(i) metallamacrocycles of bis-N-heterocyclic carbenes bridged by calixarene fragments: Synthesis, structure and chemosensing behavior
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Dinuclear Ag(i) metallamacrocycles containing bis-N-heterocyclic carbene units and calixarene fragments [{1,1′-R2-3,3′-CH 2{(p-R1-C6H2OMe)CH2} m-bisimidazol-2-ylidene}2/sub
- Lin, Cai-Xia,Kong, Xiao-Fei,Li, Qing-Shan,Zhang, Zheng-Zhi,Yuan, Yao-Feng,Xu, Feng-Bo
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p. 6948 - 6962
(2013/09/12)
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- A single sensitizer for the excitation of visible and NIR lanthanide emitters in water with high quantum yields
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Eight makes a happy Ho(l)me: The versatile octadentate TIAM ligand forms lanthanide complexes (Ln=Sm, Eu, Tb, Dy, Ho) with high quantum yields in water. This ligand is an efficient sensitizer, and also shields the metal center from solvent quenching, as shown by an X-ray diffraction study of the Ho complex. Copyright
- Law, Ga-Lai,Pham, Tiffany A.,Xu, Jide,Raymond, Kenneth N.
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supporting information; experimental part
p. 2371 - 2374
(2012/04/10)
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- COMPOUNDS
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The present invention provides the use of a compound of the Formula: (I) wherein R1 is C1-5 alkoxy, OCOC1-3Alkyl, O(CH2)2O(CH2)2O(CH2)2OMe, O(CH2)2O(CH2)2O(CH2)2OH or OH; R2 is H, (CH2)nOH, OCH3, Hal or (II) or (III) R3 is H or (CH2)nOH; and R4 is C1-6 alkyl, optionally substituted by one or more of Hal, OH, COCH3, NH2, NHCH3, NHMe, NMe2, OCOCH3, CO2H or esters or amides thereof where n is 1-5; and pharmaceutically acceptable salts thereof, in the manufacture of a medicament for use in modulating PKB activity.
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Page/Page column 7
(2009/09/08)
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- Synthesis of novel benzo-substituted macrocyclic schiff bases containing two triazole rings
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(Chemical Equation Presented) A synthesis of a series of novel macrocyclic Schiff bases containing two triazole rings 10a,b, 11a,b, 34-37 in good yields by heating the appropriate bis-amines 1f, 6a,b, 31 with the corresponding bis-aldehydes 2, 9a,b, 29 in
- Elwahy, Ahmed H. M.,Masaret, Ghada S.
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p. 1475 - 1484
(2008/09/18)
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- Synthesis and molecular orbital calculations of some benzo-substituted macrocyclic diamides and their corresponding macrocyclic dithiodiamides
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A new series of benzo-substituted macrocyclic diamides were prepared by nucleophilic reaction of the appropriate dipotassium salts with the corresponding bis(halo) compounds in refluxing DMF. Treatment of the novel macrocyclic diamides with Lawesson's reagent in refluxing toluene led to the formation of the corresponding macrocyclic dithiodiamides in good yields. Molecular orbital calculations were performed at the semi-empirical level AM1 on some of the studied macrocycles. Thermodynamic functions show that the most stable structures in gas phase that have internal amine groups are less in energy than the other ones that have internal carbonyl groups. The solvent polarity does not appreciably affect the stability trend of the three conformers of each compound due to their comparable dipole moments. A complete and thorough survey of proton affinity (PA) and proton detachment energies (PDE) on each of the possible sites has been performed.
- Mohamed, Adel A.,Masaret, Ghada S.,Elwahy, Ahmed H.M.
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p. 4000 - 4010
(2007/10/03)
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- AROMATIC TRIAMIDE-LANTHANIDE COMPLEXES
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The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
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Page/Page column 73-74
(2008/06/13)
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- Water-soluble class C β-lactamase catalytic residue mimic: Effect of proximally positioned functional groups on their pKa values
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Molecules mimicing class C β-lactamase catalytic residues were synthesized to study the effect of proximal positioning of serine, lysine and tyrosine side chains on their pKa values. The three amino acid side chains were mimicked by hydroxymethyl group, a
- Kato-Toma, Yoko,Imajo, Seiichi,Ishiguro, Masaji
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- Synthesis of macrocyclic polyhydroxy tetralactams derived from L-tartaric acid and β-hydroxyglutaric acid
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The synthesis of new 16-, 18-, 19- or 20-membered secondary tetralactams with L-tartaric acid or β-hydroxyglutaric acid moieties is investigated. The stepwise synthesis with an intermediate diamide diamine provides overall good yields (30-55%) compared with other processes using an intermediate diamide diacid or direct macrocyclization. This synthetic pathway leads to symmetrical or unsymmetrical polyhydroxytetralactams with variable hydroxyl group number. Use of mild acylating agents in this approach allows to avoid the protection-deprotection steps of hydroxyl groups.
- Arnaud, Nathalie,Picard, Claude,Cazaux, Louis,Tisnes, Pierre
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p. 13757 - 13768
(2007/10/03)
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