633327-49-8

Basic information

• Product Name: N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide
• Synonyms: N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide;2-AcetaMido-4-fluoro-5-nitrotoluene
• CAS NO: 633327-49-8
• Molecular Formula: C₉H₉FN₂O₃
• Molecular Weight: 212.179
• Mol File: 633327-49-8.mol

Chemical Properties

• Boiling Point: 393 °C at 760 mmHg
• Flash Point: 191.5 °C
• Appearance: /
• Density: 1.370
• Vapor Pressure: 2.21E-06mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide(633327-49-8)
• EPA Substance Registry System: N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide(633327-49-8)

Safety Data

• Hazardous Substances Data: 633327-49-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide is utilized as a key intermediate in the synthesis of new molecules with potential medical applications. Its unique structure allows for the creation of compounds that can target specific biological pathways or receptors, contributing to the advancement of novel therapeutic agents.
Used in the Synthesis of Potential Drug Candidates:
In the pharmaceutical industry, N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide serves as a building block for the development of drug candidates. The incorporation of fluorine and nitro groups can enhance the pharmacokinetic and pharmacodynamic properties of the resulting compounds, improving their efficacy, selectivity, and safety profiles.
Used in Medicinal Chemistry:
N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide is employed in medicinal chemistry for the design and optimization of drug-like molecules. Its versatile structure allows for the fine-tuning of molecular properties, such as lipophilicity, hydrogen bonding, and electronic effects, which are crucial for optimizing drug candidates for various therapeutic areas.
Used in Drug Discovery:
In the field of drug discovery, N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide is used as a starting material or a scaffold for the development of new chemical entities. Its unique structural features can be exploited to discover novel bioactive compounds with potential applications in treating various diseases and medical conditions.
Overall, N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide plays a significant role in the pharmaceutical industry, particularly in the discovery and development of new drugs. Its diverse chemical structure and the presence of functional groups, such as fluorine and nitro, make it a valuable asset in the synthesis of potential drug candidates and the advancement of medicinal chemistry.

InChI:InChI=1/C9H9FN2O3/c1-5-3-9(12(14)15)7(10)4-8(5)11-6(2)13/h3-4H,1-2H3,(H,11,13)

Upstream product

• 367-29-3 3-fluoro-6-methylaniline 
• 633327-50-1 5-fluoro-2-methyl-4-nitrophenylamine 
• 108-24-7 acetic anhydride 
• 366-49-4 5’-fluoro-2’-methylacetanilide 

Downstream Products

• 633327-51-2 5-nitro-6-fluoro-1H-indazole 
• 633327-50-1 5-fluoro-2-methyl-4-nitrophenylamine 

Relevant articles and documents

BENZIMIDAZOLE DERIVATIVES

The invention relates to benzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1

The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compou

BENZIMIDAZOLE DERIVATIVES AS SELECTIVE PROTEINE KINASE INHIBITORS

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof. Wherein n, R1, R2, R3, R4, R5, A, Q and X are as defined in the description. These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.

PYRAZOLE COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME

The present invention provides a novel compound having an excellent JNK inhibitory effect. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 designates -(CO)h-(NRa)j-(CRb=CRc)k-Ar (wherein Ra, Rb and Rc each independently designate a hydrogen atom, a halogen atom, hydroxyl group, an optionally substituted C1-6 alkyl group or the like; Cy designates a 5- or 6-membered heteroaryl; and V each independently designate the formula -L-X-Y (wherein L designates a single bond, an optionally substituted C1-6 alkylene group or the like; X designates a single bond or the formula -A- (wherein A designates NR2, O, CO, S, SO or SO2) and so on; and Y designates a hydrogen atom, a halogen atom, nitro group or the like).