N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide

Base Information

• Chemical Name: N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide
• CAS No.: 633327-49-8
• Molecular Formula: C9H9FN2O3
• Molecular Weight: 212.18
• Hs Code.: 2924299090
• Mol file: 633327-49-8.mol

Synonyms:Acetamide, N-(5-fluoro-2-methyl-4-nitrophenyl)-;N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide;LogP

Chemical Property of N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide

Chemical Property:

• Vapor Pressure: 2.21E-06mmHg at 25°C
• Refractive Index: 1.584
• Boiling Point: 393 °C at 760 mmHg
• Flash Point: 191.5 °C
• PSA: 78.41000
• Density: 1.370g/cm³
• LogP: 3.17340
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide

There total 3 articles about N-(5-Fluoro-2-methyl-4-nitrophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-fluoro-2-methyl-4-nitrophenylamine (633327-50-1) + acetic anhydride (108-24-7) → N-(5-fluoro-2-methyl-4-nitrophenyl)acetamide (633327-49-8)

Guidance literature:

at 15 ℃; for 36h; Inert atmosphere;

Reference yield: 79.0%

5’-fluoro-2’-methylacetanilide (366-49-4) → N-(5-fluoro-2-methyl-4-nitrophenyl)acetamide (633327-49-8)

Guidance literature:

With sulfuric acid; nitric acid; at 0 ℃; for 1h;

Reference yield:

3-fluoro-6-methylaniline (367-29-3) → N-(5-fluoro-2-methyl-4-nitrophenyl)acetamide (633327-49-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 24 h / 0 - 20 °C

2: nitric acid; sulfuric acid / 1 h / 0 °C

With sulfuric acid; nitric acid; triethylamine; In dichloromethane;

upstream raw materials:

5’-fluoro-2’-methylacetanilide

3-fluoro-6-methylaniline

5-fluoro-2-methyl-4-nitrophenylamine

acetic anhydride

Downstream raw materials:

5-fluoro-2-methyl-4-nitrophenylamine

5-nitro-6-fluoro-1H-indazole