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Thiophene-2-sulfonamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 6339-87-3 Structure
  • Basic information

    1. Product Name: Thiophene-2-sulfonamide
    2. Synonyms: BUTTPARK 44\07-11;2-Thienylsulfonamide;THIOPHENE-α-SULFONAMIDE;2-Thiophenesulfonamide(6CI,7CI,8CI,9CI);THIOPHENE-2-SULFONIC ACID AMIDE;Thiophene-2-sulphonamide;THIOPHENE-2-SULFONAMIDE;THIOPHENE-ALPHA-SULFONAMIDE
    3. CAS NO:6339-87-3
    4. Molecular Formula: C4H5NO2S2
    5. Molecular Weight: 163.22
    6. EINECS: N/A
    7. Product Categories: SULFONAMIDE;Thiophene intermediates;Building Blocks;C4 to C6;Chemical Synthesis;Heterocyclic Building Blocks;Thiophenes;Heterocycle-oher series
    8. Mol File: 6339-87-3.mol
  • Chemical Properties

    1. Melting Point: 146-148°C
    2. Boiling Point: 338.1 °C at 760 mmHg
    3. Flash Point: 158.3 °C
    4. Appearance: /
    5. Density: 1.513 g/cm3
    6. Vapor Pressure: 0.0001mmHg at 25°C
    7. Refractive Index: 1.608
    8. Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
    9. Solubility: soluble in Methanol
    10. PKA: 9.94±0.60(Predicted)
    11. CAS DataBase Reference: Thiophene-2-sulfonamide(CAS DataBase Reference)
    12. NIST Chemistry Reference: Thiophene-2-sulfonamide(6339-87-3)
    13. EPA Substance Registry System: Thiophene-2-sulfonamide(6339-87-3)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26
    4. WGK Germany: 3
    5. RTECS: XN0294000
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 6339-87-3(Hazardous Substances Data)

6339-87-3 Usage

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 7201, 1994 DOI: 10.1016/0040-4039(94)85360-6

Check Digit Verification of cas no

The CAS Registry Mumber 6339-87-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,3 and 9 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6339-87:
(6*6)+(5*3)+(4*3)+(3*9)+(2*8)+(1*7)=113
113 % 10 = 3
So 6339-87-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H5NO2S2/c5-9(6,7)4-2-1-3-8-4/h1-3H,(H2,5,6,7)

6339-87-3 Well-known Company Product Price

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  • Aldrich

  • (706655)  2-Thiophenesulfonamide  96%

  • 6339-87-3

  • 706655-1G

  • 624.78CNY

  • Detail
  • Aldrich

  • (706655)  2-Thiophenesulfonamide  96%

  • 6339-87-3

  • 706655-5G

  • 2,024.10CNY

  • Detail

6339-87-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Thiophenesulfonamide

1.2 Other means of identification

Product number -
Other names 2-Thiophenesulfonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6339-87-3 SDS

6339-87-3Relevant articles and documents

Chemoselective Cleavage of Acylsulfonamides and Sulfonamides by Aluminum Halides

Sang, Dayong,Dong, Bingqian,Liu, Yunfeng,Tian, Juan

, p. 3586 - 3595 (2022/02/25)

The chemoselective cleavage of C-N bonds of amides, sulfonamides, and acylsulfonamides by aluminum halides is described. AlCl3and AlI3display complementary reactivities toward N-alkyl and N-acyl moieties. N-Alkylacylsulfonamides, sec

Unlocking Amides through Selective C–N Bond Cleavage: Allyl Bromide-Mediated Divergent Synthesis of Nitrogen-Containing Functional Groups

Govindan, Karthick,Chen, Nian-Qi,Chuang, Yu-Wei,Lin, Wei-Yu

supporting information, p. 9419 - 9424 (2021/11/30)

We report a new set of reactions based on the unlocking of amides through simple treatment with allyl bromide, creating a common platform for accessing a diverse range of nitrogen-containing functional groups such as primary amides, sulfonamides, primary amines, N-acyl compounds (esters, thioesters, amides), and N-sulfonyl esters. The method has potential industrial applicability, as demonstrated through gram-scale syntheses in batch and in a continuous flow system.

Primary Sulfonamide Synthesis Using the Sulfinylamine Reagent N-Sulfinyl- O-(tert-butyl)hydroxylamine, t-BuONSO

Davies, Thomas Q.,Hall, Adrian,Skolc, David,Tilby, Michael J.,Willis, Michael C.

supporting information, p. 9495 - 9499 (2020/12/21)

Sulfonamides have played a defining role in the history of drug development and continue to be prevalent today. In particular, primary sulfonamides are common in marketed drugs. Here we describe the direct synthesis of these valuable compounds from organometallic reagents and a novel sulfinylamine reagent, t-BuONSO. A variety of (hetero)aryl and alkyl Grignard and organolithium reagents perform well in the reaction, providing primary sulfonamides in good to excellent yields in a convenient one-step process.

One-pot aerobic oxidative sulfonamidation of aromatic thiols with ammonia by a dual-functional β-MnO2 nanocatalyst

Hayashi, Eri,Yamaguchi, Yui,Kita, Yusuke,Kamata, Keigo,Hara, Michikazu

supporting information, p. 2095 - 2098 (2020/02/26)

High-surface-area β-MnO2 (β-MnO2-HS) nanoparticles could act as effective heterogeneous catalysts for the one-pot oxidative sulfonamidation of various aromatic and heteroaromatic thiols to the corresponding sulfonamides using molecular oxygen (O2) and ammonia (NH3) as respective oxygen and nitrogen sources, without the need for any additives.

Highly Chemoselective NH- and O-Transfer to Thiols Using Hypervalent Iodine Reagents: Synthesis of Sulfonimidates and Sulfonamides

Tota, Arianna,St John-Campbell, Sahra,Briggs, Edward L.,Estévez, Gala Ogalla,Afonso, Michelle,Degennaro, Leonardo,Luisi, Renzo,Bull, James A.

supporting information, p. 2599 - 2602 (2018/05/22)

Aryl thiols can be selectively converted to sulfonimidates or sulfonamides with three new S-X connections being made selectively in one pot. Using hypervalent iodine reagents in the presence of ammonium carbamate, NH- and O-groups are transferred under mild and practical conditions. Reducing the loading of ammonium carbamate changed the product distribution, converting the sulfonimidate to the sulfonamide. Studies into the possible intermediate species are presented, suggesting that multiple pathways may be possible via sulfinate esters, or related intermediates, with each species forming the same products.

Cu(II)-catalyzed decarboxylation/elimination of N-arylsulfonyl amino acids to primary aryl sulfonamides

Zhou, Liandi,Li, Xiaokang,Liu, Wei,Zhao, Yongli,Chen, Junmin

, p. 1299 - 1306 (2016/08/16)

A novel protocol for CuO-catalyzed decarboxylation/elimination of N-arylsulfonyl amino acids was developed. It is the first example of using an accessible amino acid as an ammonia synthetic equivalent for the synthesis of primary aryl sulfonamides via oxidative decarboxylation/elimination reactions. The present protocol shows excellent functional group tolerance and provides an efficient method for the synthesis of primary aryl sulfonamides in excellent yields.

Cu-catalyzed aerobic oxidative three-component coupling route to N -sulfonyl amidines via an ynamine intermediate

Kim, Jinho,Stahl, Shannon S.

, p. 2448 - 2454 (2015/04/14)

Cu-catalyzed aerobic oxidative three-component coupling of a terminal alkyne, secondary amine, and sulfonamide enables efficient synthesis of amidines. The use of Cu(OTf)2 (5 mol %) produces amidines selectively without Glaser-Hay alkyne homocoupling products. Preliminary studies suggest that the reaction pathway involves initial oxidative coupling of the terminal alkyne with the secondary amine, followed by hydroamidation of the ynamine intermediate with the sulfonamide.

In situ formation of vilsmeier reagents mediated by oxalyl chloride: A tool for the selective synthesis of N-sulfonylformamidines

Gazvoda, Martin,Kocevar, Marijan,Polanc, Slovenko

, p. 5381 - 5386 (2013/09/02)

N-Sulfonylformamidines were produced from sulfonamides or N-acylated sulfonamides using Vilsmeier reagent obtained in situ from N,N-disubstituted formamides and oxalyl chloride. Optically active substrates did not racemize during the process. The efficient and mild cleavage of N-sulfonylformamidines can be achieved with hydrazine hydrate in ethanol. The entire procedure constitutes a simple method for protecting, and deprotecting, the sulfonamide moiety. A straightforward and efficient synthesis for N-sulfonylformamidines by employment of various Vilsmeier reagents generated in situ is described. The reactions proceed under mild reaction conditions and tolerate several sensitive functional groups. Copyright

1,4-QUINONES AND THEIR SULFUR ANALOGUES USEFUL AS LIGANDS OF N-ACETYLTRANSFERASES

-

Page/Page column 47, (2011/06/11)

The invention provides 1,4-quinones, 1,4-naphthoquinones and their sulphur analogues as inhibitors of hNAT1, an enzyme which is both a diagnostic marker and drug target for breast cancer. Some of the compounds of the invention are also chromogenic in the

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