63498-29-3

Usage

Uses

Used in Rubber Manufacturing Industry:
Hexane diisothiourea dihydrobromide is used as an accelerator in the vulcanization of rubber for its ability to promote the cross-linking of rubber molecules. Its high solubility in water and stability under normal conditions make it a useful additive in this industry.
However, it is important to handle Hexane diisothiourea dihydrobromide with caution and use appropriate safety measures due to its potential toxicity and adverse effects on human health.

Upstream product

• 629-03-8 1 ,6-dibromohexane 
• 17356-08-0 thiourea 

Downstream Products

• 100-32-3 di(p-nitrophenyl) disulfide 
• 1223-31-0 bis(4-nitrophenyl)sulfide 
• 118542-95-3 C₁₈H₂₀N₂O₄S₂ 

Relevant academic research and scientific papers

Conversion of 3,n-Dithiabicycloalkatrienes to Bicycloalkapentaenes

The application of the Ramberg-Backlund reaction in the conversion of several 3,n-dithiabicycloalkatrienes to the corresponding bicycloalkapentaenes is reported.Proton magnetic resonance and ultraviolet spectra were utilized in the overall characterization of bicyclotetradeca-2,8,10,12,1(14)-pentaene, bicyclopentadeca-2,9,11,1(15)-pentaene, and their precursors.The final step in the synthesis was a Ramberg-Backlund of a bis-α,α'-chloro sulfone.The intermediate, 2-chloro-3-thiabicyclopentadeca-9,11,13,1(15)-tetraene-3,3-dioxide, was isolated and characterized.The structure and stability of the bridged α,α'-dichloro sulfide intermediates were examined.

Diamine and Triamine Analogs and Derivatives as Inhibitors of Deoxyhypusine Synthase: Synthesis and Biological Activity

Deoxyhypusine synthase catalyzes the initial step in the posttranslational formation of the amino acid hypusine ε-(4-amino-2-hydroxybutyl)lysine> in eukaryotic initiation factor 5A (eIF-5A). eIF-5A and its hypusine modification are believed to be essential for cell growth.A number of compounds related to diamines and triamines were synthesized and tested as inhinitors of this enzyme.The findings indicate that the long chain triamines 2a and 2b and their guanyl derivatives 3a, 3b, 4a, and 4b exert inhibition by binding to enzyme through only a portion of their structures at any one time.The inhibition exhibited by N-ethyl-1,7-diaminoheptane 20 and its guanyl derivative 21 supports this notion and is evidence for participation of the secondary amino group in binding to enzyme.There is preliminary evidence that amidino and isothiuronium groups may also serve as basic centers for binding to enzyme.Few of the compounds tested here were comparable in inhibitory potency to 1-guanidino-7-aminoheptane (GC7) the most effective known inhibitor of deoxhypusine synthase, and none proved nearly as efficient as GC7 in inhibiting the enzyme in Chinese hamster ovary cells.Hence, unlike the antiproliferative effect of GC7, for which there is evidence of cause by interference with deoxhypusine synthase catalysis (Park, M.H.; Wolff, E.C.; Lee, Y.B.; Folk, J.E.J.Biol.Chem. 269, 1994, 27827-27832), the effective growth arrest exerted by several of the newly synthesized compounds cannot be attributed to inhibition of hypusine synthesis.